AutismKB 2.0

Annotation Detail for TRIM25


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Basic Information Top
Gene Symbol:TRIM25 ( EFP,RNF147,Z147,ZNF147 )
Gene Full Name: tripartite motif-containing 25
Band: 17q23.1
Quick LinksEntrez ID:7706; OMIM: 600453; Uniprot ID:TRI25_HUMAN; ENSEMBL ID: ENSG00000121060; HGNC ID: 12932
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus33 / 56401258
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult178 / 193912191
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor21 / 94178222
cervical tumor7 / 34366203
chondrosarcoma6 / 8282372
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor16 / 26384560
glioma8 / 10688374
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia20 / 95842208
liver tumor4 / 9635941
lung tumor7 / 10312767
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal178 / 336030752
ovarian tumor8 / 76682104
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor15 / 124949120
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites3 / 4001574
bladder2 / 2975767
blood20 / 123478161
bone4 / 7165555
bone marrow6 / 48801122
brain13 / 110098911
cervix12 / 48171249
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye15 / 21105471
heart2 / 8962622
intestine17 / 23447272
kidney4 / 21177718
larynx0 / 241450 
liver9 / 20774343
lung37 / 336974109
lymph4 / 4427090
lymph node26 / 91610283
mammary gland24 / 153271156
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary10 / 10205197
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta37 / 280825131
prostate3 / 18934515
salivary gland0 / 201550 
skin20 / 21057494
spleen3 / 5395255
stomach5 / 9661951
testis4 / 33044212
thymus2 / 8113124
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus14 / 23287860
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206911_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.45
Adipocyte3.75
AdrenalCortex3.7
Adrenalgland3
Amygdala3.8
Appendix4.45
AtrioventricularNode2.7
BDCA4+_DentriticCells5.65
Bonemarrow3.55
BronchialEpithelialCells3.55
CD105+_Endothelial4.15
CD14+_Monocytes4.4
CD19+_BCells(neg._sel.)3.9
CD33+_Myeloid14.85
CD34+4.6
CD4+_Tcells4
CD56+_NKCells4.45
CD71+_EarlyErythroid3.35
CD8+_Tcells3.5
CardiacMyocytes4.5
Caudatenucleus3.2
Cerebellum2.9
CerebellumPeduncles4.65
CiliaryGanglion2.5
CingulateCortex3.65
Colorectaladenocarcinoma3.55
DorsalRootGanglion2.75
FetalThyroid3.45
Fetalbrain3.6
Fetalliver3.1
Fetallung3
GlobusPallidus2.6
Heart4.55
Hypothalamus3.7
Kidney2.85
Leukemia_chronicMyelogenousK-5623.25
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)2.9
Liver5.2
Lung3.95
Lymphnode3.1
Lymphoma_burkitts(Daudi)4.5
Lymphoma_burkitts(Raji)6.7
MedullaOblongata3.3
OccipitalLobe3.2
OlfactoryBulb2.85
Ovary2.35
Pancreas2.85
PancreaticIslet3.6
ParietalLobe3.75
Pituitary4.2
Placenta21.9
Pons3.4
PrefrontalCortex4.4
Prostate4.2
Salivarygland2.85
SkeletalMuscle4.7
Skin3
SmoothMuscle4.85
Spinalcord3.85
SubthalamicNucleus3.25
SuperiorCervicalGanglion5
TemporalLobe4.1
Testis3.1
TestisGermCell3.05
TestisIntersitial3.05
TestisLeydigCell3.5
TestisSeminiferousTubule3.1
Thalamus3.5
Thymus2.85
Thyroid4.55
Tongue3.45
Tonsil3.45
Trachea3
TrigeminalGanglion3.5
Uterus2.95
UterusCorpus3.8
WholeBlood4.15
Wholebrain3.05
colon3.7
pineal_day5.74
pineal_night4.68
retina4.4
small_intestine3.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P936767
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.3 ± 0.71
Basal Forebrain2.87 ± 0.32
Basal Part of Pons2.89 ± 0.54
Cerebellar Cortex3.39 ± 0.54
Cerebellar Nuclei3.13 ± 0.59
Claustrum3.2 ± 0.52
Epithalamus3.25 ± 0.6
Frontal Lobe3.13 ± 0.62
Globus Pallidus2.99 ± 0.96
Hypothalamus2.97 ± 0.66
Insula3.23 ± 0.79
Limbic Lobe3 ± 0.66
Mesencephalon3.23 ± 0.69
Myelencephalon3.13 ± 0.62
Occipital Lobe3.02 ± 0.72
Parietal Lobe3.08 ± 0.64
Pontine Tegmentum3.11 ± 0.66
Striatum3 ± 0.64
Subthalamus3.18 ± 0.75
Temporal Lobe3.05 ± 0.65
Thalamus3.07 ± 0.66
White Matter1.97 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Trim25CBCerebellum14.91
16.59
Trim25CTXCerebral cortex3.45
2.55
Trim25HIPHippocampal region6.95
3.91
Trim25HPFHippocampal formation8.79
5.6
Trim25HYHypothalamus3.97
3.02
Trim25LSXLateral septal complex0.35
0.33
Trim25MBMidbrain1.84
1.98
Trim25MYMedulla10.46
8.11
Trim25OLFOlfactory bulb9.2
6.47
Trim25PPons7.86
5.9
Trim25PALPallidum1.27
0.83
Trim25RHPRetrohippocampal region11.69
7.91
Trim25sAMYStriatum-like amygdalar nuclei3.36
1.93
Trim25STRStriatum1.66
1.05
Trim25STRdStriatum dorsal region0.83
0.68
Trim25STRvStriatum ventral region4.48
2.17
Trim25THThalamus2.88
2.32
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000686 17 96 112 ASAPSPNAQVACDHCLK Peptide Atlas
TRI25_HUMAN_0 0 0 0 ALLDASETTSTR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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