AutismKB 2.0

Annotation Detail for MAP3K12


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Basic Information Top
Gene Symbol:MAP3K12 ( DLK,MEKK12,MUK,ZPK,ZPKP1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 12
Band: 12q13.13
Quick LinksEntrez ID:7786; OMIM: 600447; Uniprot ID:M3K12_HUMAN; ENSEMBL ID: ENSG00000139625; HGNC ID: 6851
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus23 / 56401240
neonate0 / 310970 
infant2 / 2362084
juvenile6 / 55556107
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor3 / 26384511
glioma4 / 10688337
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal78 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow1 / 4880120
brain28 / 110098925
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye10 / 21105447
heart2 / 8962622
intestine4 / 23447217
kidney7 / 21177733
larynx3 / 24145124
liver1 / 2077434
lung15 / 33697444
lymph0 / 442700 
lymph node1 / 9161010
mammary gland4 / 15327126
mouth1 / 6705214
muscle2 / 10771518
nerve3 / 15768190
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta3 / 28082510
prostate6 / 18934531
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach3 / 9661931
testis4 / 33044212
thymus1 / 8113112
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205448_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.4
Adipocyte10.5
AdrenalCortex6.5
Adrenalgland5.2
Amygdala6.55
Appendix6.25
AtrioventricularNode4.4
BDCA4+_DentriticCells6.3
Bonemarrow5.9
BronchialEpithelialCells5.9
CD105+_Endothelial6
CD14+_Monocytes6.15
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid7.5
CD34+7.35
CD4+_Tcells9.45
CD56+_NKCells7.35
CD71+_EarlyErythroid5.55
CD8+_Tcells6.45
CardiacMyocytes7.45
Caudatenucleus13.55
Cerebellum64.5
CerebellumPeduncles56.75
CiliaryGanglion4.1
CingulateCortex9.55
Colorectaladenocarcinoma6.05
DorsalRootGanglion4.4
FetalThyroid6.2
Fetalbrain24.35
Fetalliver5.25
Fetallung4.95
GlobusPallidus4.75
Heart8.2
Hypothalamus12.7
Kidney17.25
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-605.2
Leukemialymphoblastic(MOLT-4)4.8
Liver8.25
Lung6.55
Lymphnode5.5
Lymphoma_burkitts(Daudi)7.75
Lymphoma_burkitts(Raji)8.3
MedullaOblongata13.85
OccipitalLobe6.15
OlfactoryBulb5.1
Ovary3.9
Pancreas4.85
PancreaticIslet6.35
ParietalLobe10.85
Pituitary6.95
Placenta6.2
Pons6.2
PrefrontalCortex23.4
Prostate7
Salivarygland4.9
SkeletalMuscle7.1
Skin4.6
SmoothMuscle6.85
Spinalcord17.6
SubthalamicNucleus7.2
SuperiorCervicalGanglion7.05
TemporalLobe16.05
Testis5.15
TestisGermCell5.05
TestisIntersitial4.95
TestisLeydigCell5.9
TestisSeminiferousTubule5.15
Thalamus7.45
Thymus4.85
Thyroid7.5
Tongue5.8
Tonsil5.75
Trachea5.3
TrigeminalGanglion5.75
Uterus5.5
UterusCorpus10.65
WholeBlood6.6
Wholebrain40.05
colon6
pineal_day11.54
pineal_night7.3
retina10.575
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9462_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.22 ± 0.4
Basal Forebrain5.81 ± 0.16
Basal Part of Pons6.01 ± 0.34
Cerebellar Cortex6.35 ± 0.22
Cerebellar Nuclei5.68 ± 0.25
Claustrum6.52 ± 0.77
Epithalamus5.84 ± 0.55
Frontal Lobe5.63 ± 0.46
Globus Pallidus5.3 ± 0.36
Hypothalamus5.29 ± 0.56
Insula5.61 ± 0.5
Limbic Lobe6.13 ± 0.51
Mesencephalon5.67 ± 0.53
Myelencephalon5.85 ± 0.46
Occipital Lobe6.48 ± 0.51
Parietal Lobe5.96 ± 0.45
Pontine Tegmentum5.8 ± 0.65
Striatum5.76 ± 0.52
Subthalamus5.61 ± 0.46
Temporal Lobe5.81 ± 0.46
Thalamus5.82 ± 0.37
White Matter5.43 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k12CBCerebellum98.54
100
Map3k12CTXCerebral cortex100
100
Map3k12HIPHippocampal region100
100
Map3k12HPFHippocampal formation100
100
Map3k12HYHypothalamus100
92.78
Map3k12LSXLateral septal complex100
93.8
Map3k12MBMidbrain96.14
96.54
Map3k12MYMedulla85.4
100
Map3k12OLFOlfactory bulb100
100
Map3k12PPons80.24
97.35
Map3k12PALPallidum100
100
Map3k12RHPRetrohippocampal region100
100
Map3k12sAMYStriatum-like amygdalar nuclei100
100
Map3k12STRStriatum100
88.6
Map3k12STRdStriatum dorsal region100
82.62
Map3k12STRvStriatum ventral region100
92.63
Map3k12THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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