AutismKB 2.0

Annotation Detail for ZYX


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Basic Information Top
Gene Symbol:ZYX ( ESP-2,HED-2 )
Gene Full Name: zyxin
Band: 7q34
Quick LinksEntrez ID:7791; OMIM: 602002; Uniprot ID:ZYX_HUMAN; ENSEMBL ID: ENSG00000159840; HGNC ID: 13200
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst5 / 6231980
fetus55 / 56401297
neonate4 / 31097128
infant1 / 2362042
juvenile11 / 55556197
adult411 / 1939121211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma3 / 17475171
breast (mammary gland) tumor12 / 94178127
cervical tumor6 / 34366174
chondrosarcoma10 / 82823120
colorectal tumor22 / 114246192
esophageal tumor1 / 1729057
gastrointestinal tumor21 / 119369175
germ cell tumor41 / 263845155
glioma19 / 106883177
head and neck tumor15 / 136302110
kidney tumor19 / 68959275
leukemia38 / 95842396
liver tumor7 / 9635972
lung tumor24 / 103127232
lymphoma4 / 7175555
non-neoplasia12 / 97250123
normal461 / 3360307137
ovarian tumor19 / 76682247
pancreatic tumor27 / 104616258
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer20 / 102680194
retinoblastoma1 / 4635621
skin tumor30 / 124949240
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland5 / 33197150
ascites3 / 4001574
bladder2 / 2975767
blood52 / 123478421
bone12 / 71655167
bone marrow9 / 48801184
brain76 / 110098969
cervix9 / 48171186
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus1 / 2020949
eye38 / 211054180
heart3 / 8962633
intestine42 / 234472179
kidney32 / 211777151
larynx4 / 24145165
liver13 / 20774362
lung70 / 336974207
lymph3 / 4427067
lymph node9 / 9161098
mammary gland32 / 153271208
mouth4 / 6705259
muscle7 / 10771564
nerve0 / 157680 
ovary33 / 102051323
pancreas46 / 214812214
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta53 / 280825188
prostate30 / 189345158
salivary gland5 / 20155248
skin51 / 210574242
spleen4 / 5395274
stomach16 / 96619165
testis28 / 33044284
thymus6 / 8113173
thyroid4 / 4747384
tonsil5 / 16999294
trachea1 / 5241319
umbilical cord0 / 136800 
uterus45 / 232878193
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200808_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts86.5
Adipocyte485.85
AdrenalCortex71.25
Adrenalgland74.55
Amygdala114.8
Appendix73.6
AtrioventricularNode53.5
BDCA4+_DentriticCells237.85
Bonemarrow233.75
BronchialEpithelialCells373.15
CD105+_Endothelial26.2
CD14+_Monocytes1140.65
CD19+_BCells(neg._sel.)52.55
CD33+_Myeloid836.55
CD34+109.35
CD4+_Tcells126.65
CD56+_NKCells162.65
CD71+_EarlyErythroid56.5
CD8+_Tcells148.7
CardiacMyocytes620.45
Caudatenucleus74.45
Cerebellum110.25
CerebellumPeduncles119.45
CiliaryGanglion71.8
CingulateCortex93.75
Colorectaladenocarcinoma395.45
DorsalRootGanglion58.85
FetalThyroid190
Fetalbrain130.3
Fetalliver57.2
Fetallung280.6
GlobusPallidus58.15
Heart286.2
Hypothalamus70.1
Kidney83.3
Leukemia_chronicMyelogenousK-562156.9
Leukemia_promyelocytic-HL-6041.35
Leukemialymphoblastic(MOLT-4)28.15
Liver227.65
Lung645.3
Lymphnode209.85
Lymphoma_burkitts(Daudi)107.1
Lymphoma_burkitts(Raji)111.85
MedullaOblongata96.3
OccipitalLobe85.05
OlfactoryBulb81
Ovary199.85
Pancreas50.9
PancreaticIslet114.9
ParietalLobe81.15
Pituitary64.1
Placenta303.4
Pons113.4
PrefrontalCortex188.4
Prostate278.3
Salivarygland36.35
SkeletalMuscle104.45
Skin73.9
SmoothMuscle1119.25
Spinalcord110.7
SubthalamicNucleus64.85
SuperiorCervicalGanglion65.15
TemporalLobe72.8
Testis122.6
TestisGermCell278.3
TestisIntersitial154.4
TestisLeydigCell83.25
TestisSeminiferousTubule122.1
Thalamus81.45
Thymus154.9
Thyroid230.2
Tongue95.3
Tonsil156.05
Trachea88.6
TrigeminalGanglion80.4
Uterus778.9
UterusCorpus281.8
WholeBlood1996.15
Wholebrain100.45
colon107.2
pineal_day87.82
pineal_night85.7
retina220.6
small_intestine85.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10564_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.44 ± 0.59
Basal Forebrain7.22 ± 0.25
Basal Part of Pons7.88 ± 0.28
Cerebellar Cortex7.29 ± 0.43
Cerebellar Nuclei7.82 ± 0.24
Claustrum7.97 ± 0.79
Epithalamus6.81 ± 0.38
Frontal Lobe6.94 ± 0.57
Globus Pallidus7.39 ± 0.26
Hypothalamus6.75 ± 0.47
Insula6.88 ± 0.63
Limbic Lobe7.11 ± 0.61
Mesencephalon7.19 ± 0.58
Myelencephalon7.14 ± 0.57
Occipital Lobe7.83 ± 0.61
Parietal Lobe7.39 ± 0.5
Pontine Tegmentum6.98 ± 0.54
Striatum6.41 ± 0.53
Subthalamus7.13 ± 0.22
Temporal Lobe7.04 ± 0.59
Thalamus7.11 ± 0.52
White Matter7.17 ± 0.66
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ZyxCBCerebellum18.81
21.88
ZyxCTXCerebral cortex36.14
28.03
ZyxHIPHippocampal region27.1
31.37
ZyxHPFHippocampal formation28.72
29.7
ZyxHYHypothalamus14.11
11.78
ZyxLSXLateral septal complex13.19
9.36
ZyxMBMidbrain17.75
18.53
ZyxMYMedulla39.53
54.83
ZyxOLFOlfactory bulb43.76
40.42
ZyxPPons29.65
40.4
ZyxPALPallidum13.73
12.75
ZyxRHPRetrohippocampal region32.4
28.5
ZyxsAMYStriatum-like amygdalar nuclei5.84
4.41
ZyxSTRStriatum9.66
7.17
ZyxSTRdStriatum dorsal region9.61
7.25
ZyxSTRvStriatum ventral region10.84
7.66
ZyxTHThalamus34.65
32.94
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000821 14 462 475 AYHPHCFTCVVCAR Peptide Atlas
ZYX_HUMAN_138 22 138 159 EKVSSIDLEIDSLSSLLDDMTK PRIDE
ZYX_HUMAN_138 27 138 164 EKVSSIDLEIDSLSSLLDDMTKNDPFK PRIDE
ZYX_HUMAN_140 20 140 159 VSSIDLEIDSLSSLLDDMTK PRIDE
ZYX_HUMAN_167 17 167 183 VSSGYVPPPVATPFSSK PRIDE
ZYX_HUMAN_272 23 272 294 FTPVASKFSPGAPGGSGSQPNQK PRIDE
ZYX_HUMAN_279 16 279 294 FSPGAPGGSGSQPNQK PRIDE
ZYX_HUMAN_295 25 295 319 LGHPEALSAGTGSPQPPSFTYAQQR PRIDE
ZYX_HUMAN_324 19 324 342 VQEKQHPVPPPAQNQNQVR PRIDE
ZYX_HUMAN_328 15 328 342 QHPVPPPAQNQNQVR PRIDE
ZYX_HUMAN_329 15 329 343 QHPVPPPAQNQNQVR PRIDE
ZYX_HUMAN_343 11 343 353 SPGAPGPLTLK PRIDE
ZYX_HUMAN_343 32 343 374 SPGAPGPLTLKEVEELEQLTQQLMQDMEHPQR PRIDE
ZYX_HUMAN_35 19 35 53 VNPFRPGDSEPPPAPGAQR PRIDE
ZYX_HUMAN_354 21 354 374 EVEELEQLTQQLMQDMEHPQR PRIDE
ZYX_HUMAN_355 21 355 375 EVEELEQLTQQLMQDMEHPQR PRIDE
ZYX_HUMAN_375 11 375 385 QNVAVNELCGR PRIDE
ZYX_HUMAN_504 19 504 522 CSVCSEPIMPEPGRDETVR PRIDE
ZYX_HUMAN_522 11 522 532 VVALDKNFHMK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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