AutismKB 2.0

Annotation Detail for DDR1


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Basic Information Top
Gene Symbol:DDR1 ( CAK,CD167,DDR,EDDR1,HGK2,MCK10,NEP,NTRK4,PTK3,PTK3A,RTK6,TRKE )
Gene Full Name: discoidin domain receptor tyrosine kinase 1
Band: 6p21.33
Quick LinksEntrez ID:780; OMIM: 600408; Uniprot ID:DDR1_HUMAN; ENSEMBL ID: ENSG00000204580; HGNC ID: 2730
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body16 / 70761226
blastocyst13 / 62319208
fetus104 / 564012184
neonate0 / 310970 
infant3 / 23620127
juvenile1 / 5555617
adult383 / 1939121197
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma5 / 17475286
breast (mammary gland) tumor29 / 94178307
cervical tumor4 / 34366116
chondrosarcoma5 / 8282360
colorectal tumor19 / 114246166
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor147 / 263845557
glioma63 / 106883589
head and neck tumor90 / 136302660
kidney tumor6 / 6895987
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal654 / 3360307194
ovarian tumor21 / 76682273
pancreatic tumor20 / 104616191
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer6 / 10268058
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor19 / 90257210
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites3 / 4001574
bladder8 / 29757268
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain551 / 1100989500
cervix4 / 4817183
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue41 / 215722190
esophagus2 / 2020998
eye19 / 21105490
heart6 / 8962666
intestine28 / 234472119
kidney7 / 21177733
larynx3 / 24145124
liver7 / 20774333
lung21 / 33697462
lymph0 / 442700 
lymph node3 / 9161032
mammary gland34 / 153271221
mouth82 / 670521222
muscle9 / 10771583
nerve2 / 15768126
ovary22 / 102051215
pancreas49 / 214812228
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta32 / 280825113
prostate14 / 18934573
salivary gland1 / 2015549
skin9 / 21057442
spleen1 / 5395218
stomach6 / 9661962
testis148 / 330442447
thymus26 / 81131320
thyroid4 / 4747384
tonsil0 / 169990 
trachea74 / 524131411
umbilical cord0 / 136800 
uterus30 / 232878128
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208779_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts48.95
Adipocyte23.15
AdrenalCortex46.7
Adrenalgland45.25
Amygdala122.65
Appendix17.35
AtrioventricularNode16.45
BDCA4+_DentriticCells18.1
Bonemarrow42.1
BronchialEpithelialCells168.5
CD105+_Endothelial15.75
CD14+_Monocytes9.6
CD19+_BCells(neg._sel.)34.5
CD33+_Myeloid11.7
CD34+22.5
CD4+_Tcells20.1
CD56+_NKCells16.5
CD71+_EarlyErythroid17.45
CD8+_Tcells13.75
CardiacMyocytes60.05
Caudatenucleus120
Cerebellum64.25
CerebellumPeduncles82.7
CiliaryGanglion15.4
CingulateCortex83.05
Colorectaladenocarcinoma171.65
DorsalRootGanglion16.7
FetalThyroid125.95
Fetalbrain167.65
Fetalliver22.15
Fetallung54.55
GlobusPallidus32.7
Heart65.05
Hypothalamus254.65
Kidney71.4
Leukemia_chronicMyelogenousK-56234.4
Leukemia_promyelocytic-HL-6024.7
Leukemialymphoblastic(MOLT-4)18.4
Liver32.9
Lung78.05
Lymphnode19.8
Lymphoma_burkitts(Daudi)29.4
Lymphoma_burkitts(Raji)30.9
MedullaOblongata98.05
OccipitalLobe86.95
OlfactoryBulb89.55
Ovary25.35
Pancreas107.25
PancreaticIslet163.45
ParietalLobe136.35
Pituitary82.5
Placenta136.6
Pons49.4
PrefrontalCortex186.75
Prostate205
Salivarygland52.6
SkeletalMuscle57.35
Skin38
SmoothMuscle34.85
Spinalcord491.5
SubthalamicNucleus37.05
SuperiorCervicalGanglion44.1
TemporalLobe39.25
Testis27.15
TestisGermCell36.3
TestisIntersitial22
TestisLeydigCell31.85
TestisSeminiferousTubule43.5
Thalamus152.35
Thymus89.1
Thyroid321.7
Tongue55.7
Tonsil33.7
Trachea164.4
TrigeminalGanglion21.8
Uterus32.9
UterusCorpus37.2
WholeBlood18.9
Wholebrain107.6
colon64.05
pineal_day131.38
pineal_night107.84
retina366.05
small_intestine42.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P367289
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.74 ± 0.66
Basal Forebrain5.41 ± 0.26
Basal Part of Pons4.74 ± 0.78
Cerebellar Cortex4.52 ± 0.46
Cerebellar Nuclei5.51 ± 0.79
Claustrum4.76 ± 0.86
Epithalamus5.61 ± 0.76
Frontal Lobe4.79 ± 0.7
Globus Pallidus6.79 ± 0.58
Hypothalamus5.08 ± 0.62
Insula4.27 ± 0.52
Limbic Lobe4.79 ± 0.79
Mesencephalon4.95 ± 0.8
Myelencephalon5.06 ± 0.67
Occipital Lobe5.17 ± 0.76
Parietal Lobe4.86 ± 0.82
Pontine Tegmentum5.05 ± 0.52
Striatum5.12 ± 0.68
Subthalamus4.86 ± 0.72
Temporal Lobe4.7 ± 0.59
Thalamus5.24 ± 0.62
White Matter6.91 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ddr1CBCerebellum28.99
32.98
Ddr1CTXCerebral cortex22.87
17.28
Ddr1HIPHippocampal region19.07
19.77
Ddr1HPFHippocampal formation18.53
17.08
Ddr1HYHypothalamus32.18
24.9
Ddr1LSXLateral septal complex28.42
26.73
Ddr1MBMidbrain32.49
28.21
Ddr1MYMedulla56.02
54.37
Ddr1OLFOlfactory bulb36.72
28.65
Ddr1PPons43.51
37.71
Ddr1PALPallidum32.13
26.78
Ddr1RHPRetrohippocampal region17.2
13.17
Ddr1sAMYStriatum-like amygdalar nuclei18.1
13.87
Ddr1STRStriatum23.93
19.44
Ddr1STRdStriatum dorsal region24.63
20.53
Ddr1STRvStriatum ventral region21.74
14.79
Ddr1THThalamus39.64
34.23
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DDR1_HUMAN_320 11 320 330 HNLGGNLGDPR PRIDE
PAp00096382 30 579 608 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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