AutismKB 2.0

Annotation Detail for LRP8


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Basic Information Top
Gene Symbol:LRP8 ( APOER2,HSZ75190,MCI1 )
Gene Full Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Band: 1p32.3
Quick LinksEntrez ID:7804; OMIM: 602600; Uniprot ID:LRP8_HUMAN; ENSEMBL ID: ENSG00000157193; HGNC ID: 6700
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst8 / 62319128
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal56 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder0 / 297570 
blood0 / 1234780 
bone5 / 7165569
bone marrow0 / 488010 
brain20 / 110098918
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine4 / 23447217
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung8 / 33697423
lymph2 / 4427045
lymph node1 / 9161010
mammary gland4 / 15327126
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis13 / 33044239
thymus0 / 811310 
thyroid6 / 47473126
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205282_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.5
Adipocyte8.65
AdrenalCortex10.2
Adrenalgland7.85
Amygdala10.55
Appendix11.75
AtrioventricularNode7.8
BDCA4+_DentriticCells10.65
Bonemarrow9.6
BronchialEpithelialCells9
CD105+_Endothelial8.65
CD14+_Monocytes9.2
CD19+_BCells(neg._sel.)8.65
CD33+_Myeloid10.55
CD34+10.4
CD4+_Tcells8.7
CD56+_NKCells9.55
CD71+_EarlyErythroid8.1
CD8+_Tcells8
CardiacMyocytes12.35
Caudatenucleus8.15
Cerebellum8.55
CerebellumPeduncles12.55
CiliaryGanglion6.8
CingulateCortex10.95
Colorectaladenocarcinoma9
DorsalRootGanglion7.15
FetalThyroid11.55
Fetalbrain11.25
Fetalliver7.9
Fetallung6.8
GlobusPallidus7.6
Heart13.3
Hypothalamus10.75
Kidney7.85
Leukemia_chronicMyelogenousK-56210.1
Leukemia_promyelocytic-HL-609.55
Leukemialymphoblastic(MOLT-4)8.3
Liver13.8
Lung9.7
Lymphnode7.2
Lymphoma_burkitts(Daudi)12.2
Lymphoma_burkitts(Raji)13.6
MedullaOblongata8.45
OccipitalLobe9.5
OlfactoryBulb6.9
Ovary6.25
Pancreas7
PancreaticIslet9.65
ParietalLobe10.4
Pituitary10.6
Placenta9.35
Pons9.15
PrefrontalCortex11.25
Prostate10.15
Salivarygland7.45
SkeletalMuscle17.15
Skin7.5
SmoothMuscle9.75
Spinalcord9.25
SubthalamicNucleus9.05
SuperiorCervicalGanglion13.05
TemporalLobe8.55
Testis14.35
TestisGermCell80.3
TestisIntersitial8.4
TestisLeydigCell10.05
TestisSeminiferousTubule12.85
Thalamus9.95
Thymus6.65
Thyroid12.1
Tongue9.45
Tonsil8.85
Trachea7.5
TrigeminalGanglion9.8
Uterus6.95
UterusCorpus8.45
WholeBlood9.65
Wholebrain8.7
colon8.8
pineal_day24.04
pineal_night30.36
retina19.9
small_intestine8.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P34325
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.5 ± 0.49
Basal Forebrain6.49 ± 0.26
Basal Part of Pons6.62 ± 0.36
Cerebellar Cortex6.91 ± 0.2
Cerebellar Nuclei6.17 ± 0.48
Claustrum6.39 ± 0.42
Epithalamus6.4 ± 0.47
Frontal Lobe6.75 ± 0.37
Globus Pallidus5.7 ± 0.39
Hypothalamus6.64 ± 0.31
Insula6.8 ± 0.18
Limbic Lobe6.83 ± 0.37
Mesencephalon6.52 ± 0.54
Myelencephalon6.64 ± 0.45
Occipital Lobe6.85 ± 0.38
Parietal Lobe6.74 ± 0.33
Pontine Tegmentum6.67 ± 0.46
Striatum5.96 ± 0.47
Subthalamus6.19 ± 0.21
Temporal Lobe6.69 ± 0.28
Thalamus6.79 ± 0.4
White Matter4.92 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrp8CBCerebellum27.29
80.96
Lrp8CTXCerebral cortex38.23
28.06
Lrp8HIPHippocampal region37.64
49.76
Lrp8HPFHippocampal formation38.47
41.3
Lrp8HYHypothalamus19.93
13.68
Lrp8LSXLateral septal complex13.98
13.71
Lrp8MBMidbrain20.23
16.15
Lrp8MYMedulla27.31
25.48
Lrp8OLFOlfactory bulb61.87
59.39
Lrp8PPons19.42
16.3
Lrp8PALPallidum15.6
12.43
Lrp8RHPRetrohippocampal region39.5
30.86
Lrp8sAMYStriatum-like amygdalar nuclei28.78
20.23
Lrp8STRStriatum8.98
8.17
Lrp8STRdStriatum dorsal region5.52
5.92
Lrp8STRvStriatum ventral region8.29
6.81
Lrp8THThalamus16.39
15.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042867 21 620 640 TLISSTDFLSHPFGIAVFEDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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