AutismKB 2.0

Annotation Detail for LAPTM5


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Basic Information Top
Gene Symbol:LAPTM5 ( CLAST6,FLJ61683,FLJ97251,MGC125860,MGC125861 )
Gene Full Name: lysosomal protein transmembrane 5
Band: 1p35.2
Quick LinksEntrez ID:7805; OMIM: 601476; Uniprot ID:LAPM5_HUMAN; ENSEMBL ID: ENSG00000162511; HGNC ID: 29612
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus32 / 56401256
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult172 / 193912188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor7 / 11424661
esophageal tumor4 / 17290231
gastrointestinal tumor4 / 11936933
germ cell tumor9 / 26384534
glioma12 / 106883112
head and neck tumor13 / 13630295
kidney tumor3 / 6895943
leukemia46 / 95842479
liver tumor1 / 9635910
lung tumor7 / 10312767
lymphoma10 / 71755139
non-neoplasia2 / 9725020
normal229 / 336030768
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor16 / 90257177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood29 / 123478234
bone9 / 71655125
bone marrow9 / 48801184
brain27 / 110098924
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus4 / 20209197
eye6 / 21105428
heart6 / 8962666
intestine14 / 23447259
kidney9 / 21177742
larynx2 / 2414582
liver5 / 20774324
lung26 / 33697477
lymph3 / 4427067
lymph node44 / 91610480
mammary gland4 / 15327126
mouth6 / 6705289
muscle2 / 10771518
nerve0 / 157680 
ovary5 / 10205148
pancreas23 / 214812107
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta28 / 28082599
prostate4 / 18934521
salivary gland0 / 201550 
skin3 / 21057414
spleen10 / 53952185
stomach1 / 9661910
testis0 / 3304420 
thymus3 / 8113136
thyroid6 / 47473126
tonsil9 / 16999529
trachea0 / 524130 
umbilical cord1 / 1368073
uterus24 / 232878103
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201721_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts3483.35
Adipocyte11.35
AdrenalCortex116.25
Adrenalgland193.7
Amygdala152.9
Appendix92.95
AtrioventricularNode27.3
BDCA4+_DentriticCells4847.15
Bonemarrow2232.6
BronchialEpithelialCells12.25
CD105+_Endothelial1456.45
CD14+_Monocytes7064.55
CD19+_BCells(neg._sel.)7092.25
CD33+_Myeloid7677.7
CD34+3548.5
CD4+_Tcells4724.2
CD56+_NKCells4460.25
CD71+_EarlyErythroid151.85
CD8+_Tcells3515
CardiacMyocytes7.75
Caudatenucleus126.6
Cerebellum43.5
CerebellumPeduncles92.15
CiliaryGanglion100.65
CingulateCortex24.3
Colorectaladenocarcinoma68.6
DorsalRootGanglion58.75
FetalThyroid70.3
Fetalbrain40
Fetalliver98.5
Fetallung621.55
GlobusPallidus51.2
Heart347.45
Hypothalamus492.45
Kidney22.2
Leukemia_chronicMyelogenousK-562808.1
Leukemia_promyelocytic-HL-60436.95
Leukemialymphoblastic(MOLT-4)420.8
Liver148.7
Lung1852.45
Lymphnode2235.2
Lymphoma_burkitts(Daudi)2815
Lymphoma_burkitts(Raji)1943.1
MedullaOblongata35.85
OccipitalLobe140
OlfactoryBulb277.55
Ovary117.1
Pancreas120.05
PancreaticIslet251.1
ParietalLobe38.55
Pituitary146.65
Placenta478.25
Pons45.6
PrefrontalCortex92.85
Prostate199.55
Salivarygland332.25
SkeletalMuscle42.45
Skin67.35
SmoothMuscle8.75
Spinalcord448
SubthalamicNucleus28.5
SuperiorCervicalGanglion43.25
TemporalLobe47.1
Testis18.85
TestisGermCell13.4
TestisIntersitial13.2
TestisLeydigCell10.7
TestisSeminiferousTubule17.4
Thalamus224.4
Thymus1327.45
Thyroid227.15
Tongue20.75
Tonsil2802.75
Trachea200.7
TrigeminalGanglion29.6
Uterus153.75
UterusCorpus167.5
WholeBlood6924.4
Wholebrain254.55
colon245.35
pineal_day140.12
pineal_night92.58
retina688.65
small_intestine601.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P114124
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.05 ± 1.01
Basal Forebrain2.61 ± 0.52
Basal Part of Pons2.8 ± 0.67
Cerebellar Cortex2.13 ± 0.51
Cerebellar Nuclei3.24 ± 0.59
Claustrum2.76 ± 0.65
Epithalamus3.01 ± 0.86
Frontal Lobe2.66 ± 0.72
Globus Pallidus4.18 ± 0.38
Hypothalamus2.46 ± 0.95
Insula2.67 ± 0.81
Limbic Lobe2.53 ± 0.85
Mesencephalon2.78 ± 0.68
Myelencephalon2.72 ± 0.69
Occipital Lobe2.17 ± 0.73
Parietal Lobe2.5 ± 0.79
Pontine Tegmentum2.49 ± 0.76
Striatum2.9 ± 0.59
Subthalamus3.17 ± 0.29
Temporal Lobe2.79 ± 0.72
Thalamus2.6 ± 0.7
White Matter3.67 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Laptm5CBCerebellum0.27
0.47
Laptm5CTXCerebral cortex0.88
1.09
Laptm5HIPHippocampal region0.56
0.72
Laptm5HPFHippocampal formation0.51
0.59
Laptm5HYHypothalamus0.11
0.08
Laptm5LSXLateral septal complex0.25
0.66
Laptm5MBMidbrain0.35
0.38
Laptm5MYMedulla0.3
0.35
Laptm5OLFOlfactory bulb0.91
1.53
Laptm5PPons0.1
0.18
Laptm5PALPallidum0.17
0.17
Laptm5RHPRetrohippocampal region0.4
0.38
Laptm5sAMYStriatum-like amygdalar nuclei0.53
0.56
Laptm5STRStriatum0.43
0.48
Laptm5STRdStriatum dorsal region0.48
0.52
Laptm5STRvStriatum ventral region0.28
0.21
Laptm5THThalamus0.5
0.59
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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