AutismKB 2.0

Annotation Detail for TUBA1A


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Basic Information Top
Gene Symbol:TUBA1A ( B-ALPHA-1,FLJ25113,LIS3,TUBA3 )
Gene Full Name: tubulin, alpha 1a
Band: 12q13.12
Quick LinksEntrez ID:7846; OMIM: 602529; Uniprot ID:TBA1A_HUMAN; ENSEMBL ID: ENSG00000167552; HGNC ID: 20766
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body109 / 707611540
blastocyst53 / 62319850
fetus1510 / 5640122677
neonate11 / 31097353
infant183 / 236207747
juvenile82 / 555561475
adult1019 / 1939121525
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor13 / 127941016
bladder carcinoma0 / 174750 
breast (mammary gland) tumor18 / 94178191
cervical tumor16 / 34366465
chondrosarcoma37 / 82823446
colorectal tumor13 / 114246113
esophageal tumor4 / 17290231
gastrointestinal tumor12 / 119369100
germ cell tumor491 / 2638451860
glioma89 / 106883832
head and neck tumor28 / 136302205
kidney tumor45 / 68959652
leukemia12 / 95842125
liver tumor20 / 96359207
lung tumor109 / 1031271056
lymphoma18 / 71755250
non-neoplasia197 / 972502025
normal3295 / 3360307980
ovarian tumor28 / 76682365
pancreatic tumor29 / 104616277
primitive neuroectodermal tumor of the CNS420 / 1256803341
prostate cancer11 / 102680107
retinoblastoma56 / 463561208
skin tumor49 / 124949392
soft tissue/muscle tissue tumor91 / 125191726
uterine tumor26 / 90257288
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland14 / 33197421
ascites1 / 4001524
bladder1 / 2975733
blood30 / 123478242
bone18 / 71655251
bone marrow8 / 48801163
brain2913 / 11009892645
cervix20 / 48171415
connective tissue47 / 149255314
ear11 / 16212678
embryonic tissue362 / 2157221678
esophagus9 / 20209445
eye155 / 211054734
heart22 / 89626245
intestine41 / 234472174
kidney75 / 211777354
larynx3 / 24145124
liver23 / 207743110
lung172 / 336974510
lymph17 / 44270384
lymph node0 / 916100 
mammary gland27 / 153271176
mouth5 / 6705274
muscle30 / 107715278
nerve35 / 157682219
ovary42 / 102051411
pancreas70 / 214812325
parathyroid2 / 2053997
pharynx99 / 413282395
pituitary gland12 / 16585723
placenta56 / 280825199
prostate21 / 189345110
salivary gland14 / 20155694
skin65 / 210574308
spleen4 / 5395274
stomach25 / 96619258
testis171 / 330442517
thymus12 / 81131147
thyroid3 / 4747363
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord11 / 13680804
uterus116 / 232878498
vascular20 / 51780386
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212639_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts9635.5
Adipocyte2466.9
AdrenalCortex1245.05
Adrenalgland1257.35
Amygdala12444.7
Appendix1263.95
AtrioventricularNode768.7
BDCA4+_DentriticCells3379.05
Bonemarrow3496.3
BronchialEpithelialCells5242
CD105+_Endothelial8106.5
CD14+_Monocytes2909.35
CD19+_BCells(neg._sel.)1440.3
CD33+_Myeloid5167
CD34+9117.5
CD4+_Tcells1486.55
CD56+_NKCells2499.55
CD71+_EarlyErythroid9080.5
CD8+_Tcells1189.1
CardiacMyocytes10254.85
Caudatenucleus6139.25
Cerebellum7015
CerebellumPeduncles10232.15
CiliaryGanglion2388.75
CingulateCortex8959.05
Colorectaladenocarcinoma8165.8
DorsalRootGanglion5091.25
FetalThyroid1772.5
Fetalbrain19748.25
Fetalliver2826.4
Fetallung3237.8
GlobusPallidus6953.8
Heart3325.4
Hypothalamus14495.95
Kidney549.75
Leukemia_chronicMyelogenousK-5625642.05
Leukemia_promyelocytic-HL-605596.65
Leukemialymphoblastic(MOLT-4)7725.05
Liver1245.3
Lung3196.3
Lymphnode1381.2
Lymphoma_burkitts(Daudi)6704.7
Lymphoma_burkitts(Raji)3413.5
MedullaOblongata10100.25
OccipitalLobe11831.8
OlfactoryBulb5614.05
Ovary1031.8
Pancreas990.75
PancreaticIslet2522.7
ParietalLobe12434.05
Pituitary2358.25
Placenta3349.75
Pons7887.45
PrefrontalCortex16156.05
Prostate1618.95
Salivarygland740.45
SkeletalMuscle703.2
Skin709.25
SmoothMuscle8785.35
Spinalcord14702.35
SubthalamicNucleus8743.35
SuperiorCervicalGanglion1229.95
TemporalLobe11486.8
Testis3125.85
TestisGermCell3977.85
TestisIntersitial2700.55
TestisLeydigCell1991.65
TestisSeminiferousTubule2115.3
Thalamus13259.8
Thymus4842.35
Thyroid1380.45
Tongue1655.7
Tonsil3342.05
Trachea1121.55
TrigeminalGanglion3456.55
Uterus2089.65
UterusCorpus4786.45
WholeBlood3555.5
Wholebrain12475.55
colon2281.8
pineal_day13442.62
pineal_night11661.52
retina8384.65
small_intestine2782.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P139547
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.12 ± 0.65
Basal Forebrain9.52 ± 0.29
Basal Part of Pons10.27 ± 0.49
Cerebellar Cortex9.82 ± 0.49
Cerebellar Nuclei9.87 ± 0.43
Claustrum9.62 ± 0.88
Epithalamus9.81 ± 0.64
Frontal Lobe10.01 ± 0.48
Globus Pallidus9.6 ± 0.4
Hypothalamus10.51 ± 0.49
Insula10.01 ± 0.41
Limbic Lobe9.55 ± 0.65
Mesencephalon9.64 ± 0.57
Myelencephalon9.68 ± 0.62
Occipital Lobe8.9 ± 0.71
Parietal Lobe9.62 ± 0.52
Pontine Tegmentum9.64 ± 0.52
Striatum8.65 ± 0.47
Subthalamus9.79 ± 0.48
Temporal Lobe9.9 ± 0.56
Thalamus9.68 ± 0.45
White Matter10.6 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tuba1CBCerebellum100
100
Tuba1CTXCerebral cortex100
100
Tuba1HIPHippocampal region100
100
Tuba1HPFHippocampal formation100
100
Tuba1HYHypothalamus100
100
Tuba1LSXLateral septal complex100
100
Tuba1MBMidbrain100
100
Tuba1MYMedulla100
100
Tuba1OLFOlfactory bulb100
100
Tuba1PPons100
100
Tuba1PALPallidum100
100
Tuba1RHPRetrohippocampal region100
100
Tuba1sAMYStriatum-like amygdalar nuclei100
100
Tuba1STRStriatum100
100
Tuba1STRdStriatum dorsal region100
100
Tuba1STRvStriatum ventral region100
100
Tuba1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000326 20 403 422 AFVHWYVGEGMEEGEFSEAR Peptide Atlas
TBA1A_HUMAN_105 16 105 120 GHYTIGKEIIDLVLDR PRIDE
TBA1A_HUMAN_105 18 105 122 GHYTIGKEIIDLVLDRIR PRIDE
TBA1A_HUMAN_112 9 112 120 EIIDLVLDR PRIDE
TBA1A_HUMAN_123 33 123 155 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMER PRIDE
TBA1A_HUMAN_124 32 124 155 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMER PRIDE
TBA1A_HUMAN_214 15 214 228 RNLDIERPTYTNLNR PRIDE
TBA1A_HUMAN_215 14 215 228 NLDIERPTYTNLNR PRIDE
TBA1A_HUMAN_229 14 229 242 LIGQIVSSITASLR PRIDE
TBA1A_HUMAN_243 21 243 263 FDGALNVDLTEFQTNLVPYPR PRIDE
TBA1A_HUMAN_264 16 264 279 IHFPLATYAPVISAEK PRIDE
TBA1A_HUMAN_280 24 280 303 AYHEQLSVAEITNACFEPANQMVK PRIDE
TBA1A_HUMAN_311 9 311 319 YMACCLLYR PRIDE
TBA1A_HUMAN_326 10 326 335 DVNAAIATIK PRIDE
TBA1A_HUMAN_338 14 338 351 RTIQFVDWCPTGFK PRIDE
TBA1A_HUMAN_339 13 339 351 TIQFVDWCPTGFK PRIDE
TBA1A_HUMAN_352 18 352 369 VGINYQPPTVVPGGDLAK PRIDE
TBA1A_HUMAN_373 17 373 389 AVCMLSNTTAIAEAWAR PRIDE
TBA1A_HUMAN_390 11 390 400 LDHKFDLMYAK PRIDE
TBA1A_HUMAN_390 12 390 401 LDHKFDLMYAKR PRIDE
TBA1A_HUMAN_40 20 40 59 TIGGGDDSFNTFFSETGAGK PRIDE
TBA1A_HUMAN_402 20 402 421 AFVHWYVGEGMEEGEFSEAR PRIDE
TBA1A_HUMAN_64 15 64 78 AVFVDLEPTVIDEVR PRIDE
TBA1A_HUMAN_66 14 66 79 VFVDLEPTVIDEVR PRIDE
TBA1A_HUMAN_84 12 84 95 QLFHPEQLITGK PRIDE
TBA1A_HUMAN_84 21 84 104 QLFHPEQLITGKEDAANNYAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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