AutismKB 2.0

Annotation Detail for KCNAB1


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Basic Information Top
Gene Symbol:KCNAB1 ( AKR6A3,KCNA1B,KV-BETA-1,Kvb1.3,hKvBeta3,hKvb3 )
Gene Full Name: potassium voltage-gated channel, shaker-related subfamily, beta member 1
Band: 3q25.31
Quick LinksEntrez ID:7881; OMIM: 601141; Uniprot ID:KCAB1_HUMAN; ENSEMBL ID: ENSG00000169282; HGNC ID: 6228
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma8 / 10688374
head and neck tumor3 / 13630222
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal155 / 336030746
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain143 / 1100989129
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine2 / 2344728
kidney6 / 21177728
larynx0 / 241450 
liver2 / 2077439
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth3 / 6705244
muscle0 / 1077150 
nerve2 / 15768126
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach1 / 9661910
testis1 / 3304423
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208213_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.45
Adipocyte11.05
AdrenalCortex12.7
Adrenalgland9.7
Amygdala11.45
Appendix11.65
AtrioventricularNode9.25
BDCA4+_DentriticCells11.25
Bonemarrow11.3
BronchialEpithelialCells10.65
CD105+_Endothelial11
CD14+_Monocytes11.65
CD19+_BCells(neg._sel.)11.55
CD33+_Myeloid13.65
CD34+13.6
CD4+_Tcells11.9
CD56+_NKCells12.5
CD71+_EarlyErythroid10.55
CD8+_Tcells10.3
CardiacMyocytes15.25
Caudatenucleus17.25
Cerebellum9.15
CerebellumPeduncles14.25
CiliaryGanglion11.15
CingulateCortex11.55
Colorectaladenocarcinoma11.05
DorsalRootGanglion8.95
FetalThyroid10.95
Fetalbrain10.95
Fetalliver9.8
Fetallung9.2
GlobusPallidus8.7
Heart15.3
Hypothalamus11.85
Kidney9.6
Leukemia_chronicMyelogenousK-56210.05
Leukemia_promyelocytic-HL-609.85
Leukemialymphoblastic(MOLT-4)8.75
Liver15.7
Lung12.15
Lymphnode9.5
Lymphoma_burkitts(Daudi)14.2
Lymphoma_burkitts(Raji)16.3
MedullaOblongata10.15
OccipitalLobe10.2
OlfactoryBulb8.85
Ovary7.85
Pancreas9.15
PancreaticIslet12
ParietalLobe12.5
Pituitary12.9
Placenta11.05
Pons11.2
PrefrontalCortex13.95
Prostate12.85
Salivarygland8.95
SkeletalMuscle14.25
Skin10.75
SmoothMuscle12.45
Spinalcord11.8
SubthalamicNucleus10.5
SuperiorCervicalGanglion13.55
TemporalLobe10.3
Testis9.65
TestisGermCell9.1
TestisIntersitial11.15
TestisLeydigCell11.25
TestisSeminiferousTubule9.6
Thalamus11.3
Thymus8.65
Thyroid14.2
Tongue12.45
Tonsil10.85
Trachea9.35
TrigeminalGanglion11.5
Uterus8.85
UterusCorpus12.45
WholeBlood12.05
Wholebrain9.2
colon11.15
pineal_day13.72
pineal_night13.34
retina13.525
small_intestine10.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P325205
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.22 ± 0.57
Basal Forebrain7.71 ± 0.38
Basal Part of Pons5.91 ± 0.65
Cerebellar Cortex6.87 ± 0.32
Cerebellar Nuclei6.19 ± 0.7
Claustrum7.05 ± 0.72
Epithalamus6.23 ± 0.69
Frontal Lobe7.37 ± 0.51
Globus Pallidus6.78 ± 0.8
Hypothalamus6.78 ± 0.74
Insula7.24 ± 0.43
Limbic Lobe8 ± 0.78
Mesencephalon7.41 ± 0.68
Myelencephalon7.33 ± 0.89
Occipital Lobe6.66 ± 0.93
Parietal Lobe7.47 ± 0.66
Pontine Tegmentum7.77 ± 0.61
Striatum9.8 ± 0.74
Subthalamus6.36 ± 0.47
Temporal Lobe7.43 ± 0.44
Thalamus6.86 ± 0.59
White Matter5.53 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kcnab1CBCerebellum33.3
100
Kcnab1CTXCerebral cortex73.7
86.31
Kcnab1HIPHippocampal region83.11
100
Kcnab1HPFHippocampal formation85.5
100
Kcnab1HYHypothalamus19.03
19.14
Kcnab1LSXLateral septal complex100
99.52
Kcnab1MBMidbrain39.41
49.91
Kcnab1MYMedulla54.11
96.95
Kcnab1OLFOlfactory bulb39.85
41.89
Kcnab1PPons34.07
57.9
Kcnab1PALPallidum40.28
49.17
Kcnab1RHPRetrohippocampal region78.32
97.78
Kcnab1sAMYStriatum-like amygdalar nuclei61.71
59.5
Kcnab1STRStriatum100
100
Kcnab1STRdStriatum dorsal region100
100
Kcnab1STRvStriatum ventral region100
100
Kcnab1THThalamus68.06
80.54
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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