AutismKB 2.0

Annotation Detail for LRFN4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LRFN4 ( FIGLER6,MGC3103,SALM3,SALM3. )
Gene Full Name: leucine rich repeat and fibronectin type III domain containing 4
Band: 11q13.1
Quick LinksEntrez ID:78999; OMIM: 612810; Uniprot ID:LRFN4_HUMAN; ENSEMBL ID: ENSG00000173621; HGNC ID: 28456
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst6 / 6231996
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult22 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor46 / 119369385
germ cell tumor3 / 26384511
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia0 / 972500 
normal23 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer11 / 102680107
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood2 / 12347816
bone5 / 7165569
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine8 / 23447234
kidney1 / 2117774
larynx1 / 2414541
liver0 / 2077430 
lung7 / 33697420
lymph2 / 4427045
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate12 / 18934563
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach43 / 96619445
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219491_at
Cell line Expression level Expression bar
721_B_lymphoblasts23.85
Adipocyte7.55
AdrenalCortex7.65
Adrenalgland6.7
Amygdala32.45
Appendix7.1
AtrioventricularNode5.75
BDCA4+_DentriticCells24.1
Bonemarrow7.35
BronchialEpithelialCells7.3
CD105+_Endothelial41.4
CD14+_Monocytes8.6
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid10.5
CD34+52.85
CD4+_Tcells8.25
CD56+_NKCells8.65
CD71+_EarlyErythroid7.1
CD8+_Tcells7.05
CardiacMyocytes11.2
Caudatenucleus9.8
Cerebellum11.7
CerebellumPeduncles25
CiliaryGanglion5.35
CingulateCortex11.55
Colorectaladenocarcinoma78.5
DorsalRootGanglion5.75
FetalThyroid9.1
Fetalbrain91.8
Fetalliver6.55
Fetallung6
GlobusPallidus5.85
Heart11.3
Hypothalamus8.6
Kidney6.05
Leukemia_chronicMyelogenousK-5626.95
Leukemia_promyelocytic-HL-6014
Leukemialymphoblastic(MOLT-4)12.05
Liver9.95
Lung8.2
Lymphnode9.75
Lymphoma_burkitts(Daudi)9.35
Lymphoma_burkitts(Raji)10.65
MedullaOblongata8.95
OccipitalLobe7.15
OlfactoryBulb5.7
Ovary4.75
Pancreas5.6
PancreaticIslet7.85
ParietalLobe7.75
Pituitary6.95
Placenta7.1
Pons9.25
PrefrontalCortex21.1
Prostate8.65
Salivarygland5.9
SkeletalMuscle8.5
Skin5.8
SmoothMuscle12.95
Spinalcord8.75
SubthalamicNucleus9.5
SuperiorCervicalGanglion8.2
TemporalLobe25.05
Testis12.8
TestisGermCell6.1
TestisIntersitial4.1
TestisLeydigCell7.45
TestisSeminiferousTubule6.95
Thalamus9.65
Thymus3.4
Thyroid9.1
Tongue7.3
Tonsil7.4
Trachea6.3
TrigeminalGanglion7.7
Uterus6.2
UterusCorpus5.35
WholeBlood4.25
Wholebrain14
colon14.5
pineal_day16.92
pineal_night11.22
retina9.5
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6086_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.27 ± 0.68
Basal Forebrain4 ± 0.66
Basal Part of Pons4.44 ± 0.52
Cerebellar Cortex4.99 ± 0.38
Cerebellar Nuclei3.99 ± 0.51
Claustrum4.34 ± 1.04
Epithalamus4.49 ± 1.07
Frontal Lobe4.59 ± 0.61
Globus Pallidus2.85 ± 0.68
Hypothalamus4.21 ± 0.75
Insula4.83 ± 0.32
Limbic Lobe4.48 ± 0.68
Mesencephalon4.27 ± 0.74
Myelencephalon4.34 ± 0.7
Occipital Lobe4.06 ± 0.6
Parietal Lobe4.31 ± 0.59
Pontine Tegmentum4.37 ± 0.64
Striatum3.62 ± 0.67
Subthalamus4.45 ± 0.73
Temporal Lobe4.78 ± 0.6
Thalamus4.34 ± 0.6
White Matter3.28 ± 0.85
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrfn4CBCerebellum11.44
13.5
Lrfn4CTXCerebral cortex33.26
22.34
Lrfn4HIPHippocampal region15.67
14.17
Lrfn4HPFHippocampal formation24.97
21.15
Lrfn4HYHypothalamus7.83
5.72
Lrfn4LSXLateral septal complex6.4
4.35
Lrfn4MBMidbrain7.48
6.34
Lrfn4MYMedulla14.74
14.95
Lrfn4OLFOlfactory bulb33.43
25.55
Lrfn4PPons10.04
9.83
Lrfn4PALPallidum14.41
11.68
Lrfn4RHPRetrohippocampal region42.59
32.44
Lrfn4sAMYStriatum-like amygdalar nuclei22.78
14.72
Lrfn4STRStriatum15.56
10.09
Lrfn4STRdStriatum dorsal region14.64
9.66
Lrfn4STRvStriatum ventral region20.65
12.46
Lrfn4THThalamus12.34
9.02
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved