AutismKB 2.0

Annotation Detail for VKORC1


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Basic Information Top
Gene Symbol:VKORC1 ( EDTP308,FLJ00289,IMAGE3455200,MGC2694,MST134,MST576,VKCFD2,VKOR )
Gene Full Name: vitamin K epoxide reductase complex, subunit 1
Band: 16p11.2
Quick LinksEntrez ID:79001; OMIM: 608547; Uniprot ID:VKOR1_HUMAN; ENSEMBL ID: ENSG00000167397; HGNC ID: 23663
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus45 / 56401279
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult129 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma12 / 82823144
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor10 / 26384537
glioma15 / 106883140
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia2 / 9584220
liver tumor7 / 9635972
lung tumor9 / 10312787
lymphoma3 / 7175541
non-neoplasia6 / 9725061
normal234 / 336030769
ovarian tumor6 / 7668278
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer7 / 10268068
retinoblastoma6 / 46356129
skin tumor11 / 12494988
soft tissue/muscle tissue tumor17 / 125191135
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder0 / 297570 
blood2 / 12347816
bone13 / 71655181
bone marrow2 / 4880140
brain46 / 110098941
cervix0 / 481710 
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus1 / 2020949
eye20 / 21105494
heart14 / 89626156
intestine13 / 23447255
kidney22 / 211777103
larynx0 / 241450 
liver15 / 20774372
lung29 / 33697486
lymph3 / 4427067
lymph node2 / 9161021
mammary gland7 / 15327145
mouth1 / 6705214
muscle11 / 107715102
nerve0 / 157680 
ovary10 / 10205197
pancreas54 / 214812251
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta10 / 28082535
prostate19 / 189345100
salivary gland5 / 20155248
skin26 / 210574123
spleen3 / 5395255
stomach1 / 9661910
testis18 / 33044254
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus20 / 23287885
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217949_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts283.4
Adipocyte410.75
AdrenalCortex44.55
Adrenalgland143.65
Amygdala80.2
Appendix115.7
AtrioventricularNode32.8
BDCA4+_DentriticCells168.05
Bonemarrow97.4
BronchialEpithelialCells184.65
CD105+_Endothelial137.5
CD14+_Monocytes105.85
CD19+_BCells(neg._sel.)51.95
CD33+_Myeloid133.9
CD34+242.05
CD4+_Tcells104.05
CD56+_NKCells127.25
CD71+_EarlyErythroid49.95
CD8+_Tcells76.45
CardiacMyocytes224.4
Caudatenucleus53.5
Cerebellum67.95
CerebellumPeduncles68.6
CiliaryGanglion25.75
CingulateCortex57.35
Colorectaladenocarcinoma61.05
DorsalRootGanglion39.9
FetalThyroid192.8
Fetalbrain31.9
Fetalliver91.05
Fetallung130.5
GlobusPallidus33.35
Heart296.4
Hypothalamus89.3
Kidney114.65
Leukemia_chronicMyelogenousK-562102.7
Leukemia_promyelocytic-HL-60134.1
Leukemialymphoblastic(MOLT-4)132.05
Liver811.75
Lung467.05
Lymphnode94.5
Lymphoma_burkitts(Daudi)76.05
Lymphoma_burkitts(Raji)227.45
MedullaOblongata41.5
OccipitalLobe45.65
OlfactoryBulb137.1
Ovary123.5
Pancreas79.9
PancreaticIslet264.5
ParietalLobe46.5
Pituitary256.15
Placenta132.95
Pons42.55
PrefrontalCortex41.25
Prostate227.5
Salivarygland47
SkeletalMuscle23.3
Skin36.7
SmoothMuscle586.55
Spinalcord77.3
SubthalamicNucleus50.95
SuperiorCervicalGanglion19.05
TemporalLobe46
Testis105.75
TestisGermCell102.35
TestisIntersitial49.65
TestisLeydigCell43.15
TestisSeminiferousTubule68.35
Thalamus79.85
Thymus110.55
Thyroid452.65
Tongue34.5
Tonsil41.15
Trachea114.45
TrigeminalGanglion20.25
Uterus211.65
UterusCorpus61.45
WholeBlood105.5
Wholebrain104.3
colon97.25
pineal_day377.5
pineal_night383.3
retina156.3
small_intestine66.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17059_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.65 ± 0.49
Basal Forebrain5.92 ± 0.41
Basal Part of Pons6.56 ± 0.65
Cerebellar Cortex6.52 ± 0.46
Cerebellar Nuclei6.31 ± 0.41
Claustrum5.13 ± 0.97
Epithalamus6.26 ± 0.62
Frontal Lobe6.32 ± 0.56
Globus Pallidus6.22 ± 0.17
Hypothalamus6.68 ± 0.62
Insula6.21 ± 0.51
Limbic Lobe5.62 ± 0.69
Mesencephalon6.05 ± 0.62
Myelencephalon6.08 ± 0.67
Occipital Lobe5.51 ± 0.5
Parietal Lobe5.95 ± 0.61
Pontine Tegmentum6 ± 0.6
Striatum5.78 ± 0.58
Subthalamus6.55 ± 0.63
Temporal Lobe6.08 ± 0.59
Thalamus6.2 ± 0.56
White Matter7.33 ± 0.83
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Vkorc1CBCerebellum20.95
30.33
Vkorc1CTXCerebral cortex31.56
24.01
Vkorc1HIPHippocampal region23.94
23.22
Vkorc1HPFHippocampal formation24.46
21.86
Vkorc1HYHypothalamus13.73
10.69
Vkorc1LSXLateral septal complex9.22
9.92
Vkorc1MBMidbrain8.52
9.43
Vkorc1MYMedulla11.84
15.77
Vkorc1OLFOlfactory bulb34.41
30.45
Vkorc1PPons19.3
27.72
Vkorc1PALPallidum7.03
5.83
Vkorc1RHPRetrohippocampal region25.89
20.26
Vkorc1sAMYStriatum-like amygdalar nuclei7.2
4.46
Vkorc1STRStriatum9.16
7.06
Vkorc1STRdStriatum dorsal region7.1
5.44
Vkorc1STRvStriatum ventral region16.67
11.49
Vkorc1THThalamus4.77
3.59
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000504 13 41 53 ALCDVGTAISCSR Peptide Atlas
VKOR1_HUMAN_40 13 40 52 ALCDVGTAISCSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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