AutismKB 2.0

Annotation Detail for FTO


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Basic Information Top
Gene Symbol:FTO ( KIAA1752,MGC5149 )
Gene Full Name: fat mass and obesity associated
Band: 16q12.2
Quick LinksEntrez ID:79068; OMIM: 610966; Uniprot ID:FTO_HUMAN; ENSEMBL ID: ENSG00000140718; HGNC ID: 24678
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus22 / 56401239
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor5 / 34366145
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor15 / 26384556
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal157 / 336030746
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma3 / 4635664
skin tumor4 / 12494932
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow2 / 4880140
brain89 / 110098980
cervix5 / 48171103
connective tissue3 / 14925520
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye10 / 21105447
heart1 / 8962611
intestine3 / 23447212
kidney5 / 21177723
larynx2 / 2414582
liver5 / 20774324
lung6 / 33697417
lymph0 / 442700 
lymph node1 / 9161010
mammary gland6 / 15327139
mouth2 / 6705229
muscle5 / 10771546
nerve0 / 157680 
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta4 / 28082514
prostate5 / 18934526
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach2 / 9661920
testis10 / 33044230
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209702_at
Cell line Expression level Expression bar
721_B_lymphoblasts257.45
Adipocyte113.05
AdrenalCortex130.85
Adrenalgland223.05
Amygdala547.2
Appendix79.8
AtrioventricularNode41.1
BDCA4+_DentriticCells117.35
Bonemarrow72.7
BronchialEpithelialCells112.55
CD105+_Endothelial88.2
CD14+_Monocytes109.5
CD19+_BCells(neg._sel.)120.15
CD33+_Myeloid42.4
CD34+146.75
CD4+_Tcells125.15
CD56+_NKCells148.45
CD71+_EarlyErythroid31.65
CD8+_Tcells100.05
CardiacMyocytes80.45
Caudatenucleus389.25
Cerebellum247.2
CerebellumPeduncles235.45
CiliaryGanglion36.6
CingulateCortex272.1
Colorectaladenocarcinoma69.65
DorsalRootGanglion36.2
FetalThyroid116.6
Fetalbrain237.65
Fetalliver67.05
Fetallung119.75
GlobusPallidus136.5
Heart101.55
Hypothalamus543.45
Kidney132.7
Leukemia_chronicMyelogenousK-56250.55
Leukemia_promyelocytic-HL-6066.1
Leukemialymphoblastic(MOLT-4)88.05
Liver130.25
Lung184.3
Lymphnode78.15
Lymphoma_burkitts(Daudi)119.65
Lymphoma_burkitts(Raji)93.7
MedullaOblongata273.4
OccipitalLobe304.3
OlfactoryBulb169.55
Ovary36.15
Pancreas29.85
PancreaticIslet142.8
ParietalLobe279.6
Pituitary331.25
Placenta153.15
Pons193.85
PrefrontalCortex660.5
Prostate132.85
Salivarygland68.4
SkeletalMuscle97.6
Skin66.1
SmoothMuscle133.2
Spinalcord297.05
SubthalamicNucleus221
SuperiorCervicalGanglion74.25
TemporalLobe247.95
Testis48.2
TestisGermCell49.25
TestisIntersitial29.25
TestisLeydigCell51.7
TestisSeminiferousTubule44.7
Thalamus259.65
Thymus115.1
Thyroid203.3
Tongue74.55
Tonsil46.05
Trachea118.6
TrigeminalGanglion70.55
Uterus130.5
UterusCorpus52.1
WholeBlood90.7
Wholebrain369.1
colon124.35
pineal_day540.44
pineal_night706.28
retina359.575
small_intestine144.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P113184
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.07 ± 0.25
Basal Forebrain10.21 ± 0.11
Basal Part of Pons10.23 ± 0.22
Cerebellar Cortex10.07 ± 0.16
Cerebellar Nuclei10.26 ± 0.12
Claustrum10.16 ± 0.17
Epithalamus10.31 ± 0.26
Frontal Lobe10.2 ± 0.23
Globus Pallidus9.8 ± 0.21
Hypothalamus10.49 ± 0.32
Insula10.22 ± 0.16
Limbic Lobe10.11 ± 0.28
Mesencephalon10.24 ± 0.19
Myelencephalon10.18 ± 0.28
Occipital Lobe10.14 ± 0.25
Parietal Lobe10.24 ± 0.24
Pontine Tegmentum10.2 ± 0.29
Striatum10.55 ± 0.26
Subthalamus10.16 ± 0.17
Temporal Lobe10.2 ± 0.23
Thalamus10.19 ± 0.23
White Matter9.82 ± 0.17
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003554 15 127 141 HTEAEIAAACETFLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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