AutismKB 2.0

Annotation Detail for DERL1


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Basic Information Top
Gene Symbol:DERL1 ( DER-1,DER1,FLJ13784,FLJ42092,MGC3067,PRO2577 )
Gene Full Name: Der1-like domain family, member 1
Band: 8q24.13
Quick LinksEntrez ID:79139; OMIM: 608813; Uniprot ID:DERL1_HUMAN; ENSEMBL ID: ENSG00000136986; HGNC ID: 28454
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus80 / 564012141
neonate2 / 3109764
infant0 / 236200 
juvenile5 / 5555689
adult128 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor7 / 11424661
esophageal tumor3 / 17290173
gastrointestinal tumor13 / 119369108
germ cell tumor34 / 263845128
glioma8 / 10688374
head and neck tumor17 / 136302124
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor7 / 9635972
lung tumor6 / 10312758
lymphoma1 / 7175513
non-neoplasia12 / 97250123
normal316 / 336030794
ovarian tumor5 / 7668265
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland3 / 3319790
ascites4 / 4001599
bladder4 / 29757134
blood8 / 12347864
bone9 / 71655125
bone marrow1 / 4880120
brain105 / 110098995
cervix1 / 4817120
connective tissue14 / 14925593
ear7 / 16212431
embryonic tissue16 / 21572274
esophagus3 / 20209148
eye17 / 21105480
heart8 / 8962689
intestine23 / 23447298
kidney23 / 211777108
larynx0 / 241450 
liver18 / 20774386
lung31 / 33697491
lymph1 / 4427022
lymph node12 / 91610130
mammary gland10 / 15327165
mouth15 / 67052223
muscle4 / 10771537
nerve1 / 1576863
ovary5 / 10205148
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta13 / 28082546
prostate15 / 18934579
salivary gland0 / 201550 
skin22 / 210574104
spleen7 / 53952129
stomach7 / 9661972
testis40 / 330442121
thymus13 / 81131160
thyroid3 / 4747363
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus20 / 23287885
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218172_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts20.1
Adipocyte11.75
AdrenalCortex10.1
Adrenalgland7.45
Amygdala9.85
Appendix9.7
AtrioventricularNode8.75
BDCA4+_DentriticCells27.9
Bonemarrow9.55
BronchialEpithelialCells14.45
CD105+_Endothelial8.25
CD14+_Monocytes10.15
CD19+_BCells(neg._sel.)23.75
CD33+_Myeloid23.25
CD34+11.25
CD4+_Tcells41.1
CD56+_NKCells81.55
CD71+_EarlyErythroid8.5
CD8+_Tcells31.1
CardiacMyocytes15.7
Caudatenucleus7.25
Cerebellum7.1
CerebellumPeduncles10.35
CiliaryGanglion7.25
CingulateCortex8.3
Colorectaladenocarcinoma8.35
DorsalRootGanglion7.1
FetalThyroid8.35
Fetalbrain11.3
Fetalliver7.45
Fetallung6.25
GlobusPallidus6.75
Heart13.1
Hypothalamus9
Kidney7.5
Leukemia_chronicMyelogenousK-5628.1
Leukemia_promyelocytic-HL-607.4
Leukemialymphoblastic(MOLT-4)6.2
Liver12.5
Lung10.7
Lymphnode11.8
Lymphoma_burkitts(Daudi)12.05
Lymphoma_burkitts(Raji)12.85
MedullaOblongata7.15
OccipitalLobe7.15
OlfactoryBulb6.2
Ovary6.15
Pancreas8.35
PancreaticIslet9.3
ParietalLobe9.05
Pituitary15.35
Placenta18.65
Pons8
PrefrontalCortex10.5
Prostate10.05
Salivarygland7.25
SkeletalMuscle12.3
Skin7.35
SmoothMuscle15.9
Spinalcord8.45
SubthalamicNucleus7.85
SuperiorCervicalGanglion11.7
TemporalLobe7.55
Testis8.3
TestisGermCell6.25
TestisIntersitial6.85
TestisLeydigCell8.35
TestisSeminiferousTubule6.85
Thalamus8.65
Thymus8.85
Thyroid11.7
Tongue9.05
Tonsil8.7
Trachea10.1
TrigeminalGanglion9.95
Uterus7.85
UterusCorpus8.4
WholeBlood34.4
Wholebrain6.9
colon28.7
pineal_day47.4
pineal_night76.46
retina30.9
small_intestine27.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P216043
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.46 ± 0.41
Basal Forebrain5.14 ± 0.68
Basal Part of Pons5.92 ± 0.22
Cerebellar Cortex5.88 ± 0.3
Cerebellar Nuclei5.31 ± 0.55
Claustrum5.01 ± 0.75
Epithalamus5.76 ± 0.6
Frontal Lobe5.57 ± 0.43
Globus Pallidus5.11 ± 0.39
Hypothalamus5.75 ± 0.51
Insula5.72 ± 0.37
Limbic Lobe5.51 ± 0.6
Mesencephalon5.32 ± 0.48
Myelencephalon5.49 ± 0.53
Occipital Lobe5.34 ± 0.46
Parietal Lobe5.36 ± 0.48
Pontine Tegmentum5.53 ± 0.58
Striatum5.13 ± 0.42
Subthalamus5.13 ± 0.48
Temporal Lobe5.73 ± 0.48
Thalamus5.76 ± 0.41
White Matter6.01 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Derl1CBCerebellum13.33
27
Derl1CTXCerebral cortex18.5
16.19
Derl1HIPHippocampal region35.72
70.32
Derl1HPFHippocampal formation26.29
44.77
Derl1HYHypothalamus7.08
8.29
Derl1LSXLateral septal complex9.63
9.26
Derl1MBMidbrain3.53
5.72
Derl1MYMedulla5.22
8.9
Derl1OLFOlfactory bulb25.01
28.48
Derl1PPons3.45
7.58
Derl1PALPallidum13.17
14.42
Derl1RHPRetrohippocampal region11.91
13.25
Derl1sAMYStriatum-like amygdalar nuclei12.85
12.32
Derl1STRStriatum6.37
5.71
Derl1STRdStriatum dorsal region3.72
3.48
Derl1STRvStriatum ventral region10.41
7.95
Derl1THThalamus13.51
15.83
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DERL1_HUMAN_197 11 197 207 NFLSTPQFLYR PRIDE
DERL1_HUMAN_214 15 214 228 RGGVSGFGVPPASMR PRIDE
DERL1_HUMAN_215 14 215 228 GGVSGFGVPPASMR PRIDE
PAp00531516 19 31 49 LGLISPAYLFLWPEAFLYR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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