AutismKB 2.0

Annotation Detail for IRX3


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Basic Information Top
Gene Symbol:IRX3 ( FLJ99187,IRX-1,IRXB1 )
Gene Full Name: iroquois homeobox 3
Band: 16q12.2
Quick LinksEntrez ID:79191; OMIM: 612985; Uniprot ID:IRX3_HUMAN; ENSEMBL ID: ENSG00000177508; HGNC ID: 14360
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult16 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal37 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain5 / 11009894
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye1 / 2110544
heart4 / 8962644
intestine0 / 2344720 
kidney9 / 21177742
larynx0 / 241450 
liver3 / 20774314
lung17 / 33697450
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate5 / 18934526
salivary gland2 / 2015599
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P207195
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.18 ± 0.67
Basal Forebrain9.82 ± 0.19
Basal Part of Pons10.06 ± 0.43
Cerebellar Cortex9.46 ± 0.5
Cerebellar Nuclei9.97 ± 0.43
Claustrum10.21 ± 0.54
Epithalamus9.56 ± 0.68
Frontal Lobe9.9 ± 0.5
Globus Pallidus10.44 ± 0.32
Hypothalamus9.66 ± 0.62
Insula9.84 ± 0.65
Limbic Lobe9.93 ± 0.52
Mesencephalon9.9 ± 0.49
Myelencephalon9.91 ± 0.56
Occipital Lobe9.66 ± 0.67
Parietal Lobe9.76 ± 0.47
Pontine Tegmentum9.67 ± 0.52
Striatum10.02 ± 0.49
Subthalamus9.93 ± 0.14
Temporal Lobe9.76 ± 0.55
Thalamus9.87 ± 0.43
White Matter10.37 ± 0.25
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018