AutismKB 2.0

Annotation Detail for THOC6


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Basic Information Top
Gene Symbol:THOC6 ( MGC2655,WDR58,fSAP35 )
Gene Full Name: THO complex 6 homolog (Drosophila)
Band: 16p13.3
Quick LinksEntrez ID:79228; OMIM: NA; Uniprot ID:THOC6_HUMAN; ENSEMBL ID: ENSG00000131652; HGNC ID: 28369
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst6 / 6231996
fetus3 / 5640125
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult69 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor10 / 11424687
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor21 / 26384579
glioma4 / 10688337
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor8 / 9635983
lung tumor11 / 103127106
lymphoma13 / 71755181
non-neoplasia0 / 972500 
normal48 / 336030714
ovarian tumor9 / 76682117
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood5 / 12347840
bone4 / 7165555
bone marrow0 / 488010 
brain13 / 110098911
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye7 / 21105433
heart2 / 8962622
intestine15 / 23447263
kidney2 / 2117779
larynx2 / 2414582
liver9 / 20774343
lung12 / 33697435
lymph9 / 44270203
lymph node2 / 9161021
mammary gland5 / 15327132
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary13 / 102051127
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate3 / 18934515
salivary gland1 / 2015549
skin7 / 21057433
spleen3 / 5395255
stomach0 / 966190 
testis4 / 33044212
thymus1 / 8113112
thyroid1 / 4747321
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218848_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.9
Adipocyte4.15
AdrenalCortex4.4
Adrenalgland3.5
Amygdala4.45
Appendix4.25
AtrioventricularNode3.15
BDCA4+_DentriticCells30
Bonemarrow4.15
BronchialEpithelialCells4.2
CD105+_Endothelial16.5
CD14+_Monocytes10.7
CD19+_BCells(neg._sel.)10.55
CD33+_Myeloid23.2
CD34+34.25
CD4+_Tcells10.9
CD56+_NKCells15.75
CD71+_EarlyErythroid10.2
CD8+_Tcells4.95
CardiacMyocytes6.35
Caudatenucleus3.75
Cerebellum3.35
CerebellumPeduncles4.8
CiliaryGanglion3
CingulateCortex4.3
Colorectaladenocarcinoma4.35
DorsalRootGanglion3.25
FetalThyroid4.1
Fetalbrain4.2
Fetalliver3.65
Fetallung3.55
GlobusPallidus3.05
Heart5.7
Hypothalamus4.55
Kidney3.4
Leukemia_chronicMyelogenousK-5623.9
Leukemia_promyelocytic-HL-605.6
Leukemialymphoblastic(MOLT-4)5
Liver5.7
Lung5.5
Lymphnode3.65
Lymphoma_burkitts(Daudi)6.45
Lymphoma_burkitts(Raji)6.1
MedullaOblongata3.8
OccipitalLobe3.8
OlfactoryBulb3.3
Ovary2.8
Pancreas3.4
PancreaticIslet4.55
ParietalLobe4.4
Pituitary4.9
Placenta4.45
Pons4
PrefrontalCortex5.3
Prostate6.4
Salivarygland3.3
SkeletalMuscle4.9
Skin3.2
SmoothMuscle4.8
Spinalcord4.5
SubthalamicNucleus3.8
SuperiorCervicalGanglion4.75
TemporalLobe3.85
Testis3.6
TestisGermCell3.45
TestisIntersitial3.55
TestisLeydigCell4.2
TestisSeminiferousTubule3.6
Thalamus4.25
Thymus4.95
Thyroid5.35
Tongue4.1
Tonsil4.1
Trachea3.5
TrigeminalGanglion4.2
Uterus3.5
UterusCorpus3.8
WholeBlood4.7
Wholebrain3.55
colon4.3
pineal_day5.34
pineal_night5.22
retina5.1
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P37949
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.8 ± 0.62
Basal Forebrain3.65 ± 0.36
Basal Part of Pons3.76 ± 0.5
Cerebellar Cortex3.56 ± 0.46
Cerebellar Nuclei3.76 ± 0.47
Claustrum4.03 ± 0.72
Epithalamus3.35 ± 0.31
Frontal Lobe3.63 ± 0.6
Globus Pallidus4.08 ± 0.38
Hypothalamus3.62 ± 0.32
Insula3.22 ± 0.83
Limbic Lobe3.81 ± 0.62
Mesencephalon3.7 ± 0.52
Myelencephalon3.75 ± 0.59
Occipital Lobe3.79 ± 0.46
Parietal Lobe3.69 ± 0.5
Pontine Tegmentum3.62 ± 0.62
Striatum3.87 ± 0.5
Subthalamus3.35 ± 1.01
Temporal Lobe3.61 ± 0.53
Thalamus3.76 ± 0.53
White Matter4.12 ± 0.3
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002868 12 166 177 GHTDYIHCLALR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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