AutismKB 2.0

Annotation Detail for KREMEN2


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Basic Information Top
Gene Symbol:KREMEN2 ( KRM2,MGC10791,MGC16709 )
Gene Full Name: kringle containing transmembrane protein 2
Band: 16p13.3
Quick LinksEntrez ID:79412; OMIM: 609899; Uniprot ID:KREM2_HUMAN; ENSEMBL ID: ENSG00000131650; HGNC ID: 18797
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor24 / 119369201
germ cell tumor11 / 26384541
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal11 / 33603073
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain13 / 110098911
cervix5 / 48171103
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye4 / 21105418
heart1 / 8962611
intestine4 / 23447217
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach19 / 96619196
testis5 / 33044215
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219692_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.95
Adipocyte3.4
AdrenalCortex3.6
Adrenalgland2.9
Amygdala3.6
Appendix3.4
AtrioventricularNode3.3
BDCA4+_DentriticCells3.9
Bonemarrow3.35
BronchialEpithelialCells3.35
CD105+_Endothelial3.5
CD14+_Monocytes3.7
CD19+_BCells(neg._sel.)4
CD33+_Myeloid4.5
CD34+4.4
CD4+_Tcells3.8
CD56+_NKCells4.2
CD71+_EarlyErythroid3.25
CD8+_Tcells3.3
CardiacMyocytes4.35
Caudatenucleus3.05
Cerebellum2.8
CerebellumPeduncles4
CiliaryGanglion2.45
CingulateCortex3.5
Colorectaladenocarcinoma3.65
DorsalRootGanglion2.6
FetalThyroid3.95
Fetalbrain3.45
Fetalliver3
Fetallung2.8
GlobusPallidus2.55
Heart4.35
Hypothalamus3.75
Kidney2.75
Leukemia_chronicMyelogenousK-5623.15
Leukemia_promyelocytic-HL-604
Leukemialymphoblastic(MOLT-4)2.8
Liver4.55
Lung3.8
Lymphnode2.95
Lymphoma_burkitts(Daudi)4.4
Lymphoma_burkitts(Raji)11.25
MedullaOblongata3.1
OccipitalLobe3.1
OlfactoryBulb2.85
Ovary2.3
Pancreas2.75
PancreaticIslet3.65
ParietalLobe3.65
Pituitary4
Placenta3.55
Pons3.25
PrefrontalCortex4.25
Prostate4.05
Salivarygland2.7
SkeletalMuscle4.05
Skin2.65
SmoothMuscle3.9
Spinalcord3.7
SubthalamicNucleus3.45
SuperiorCervicalGanglion3.8
TemporalLobe3.1
Testis2.95
TestisGermCell2.85
TestisIntersitial2.9
TestisLeydigCell3.35
TestisSeminiferousTubule2.95
Thalamus3.5
Thymus2.75
Thyroid4.3
Tongue3.35
Tonsil3.35
Trachea2.9
TrigeminalGanglion3.75
Uterus2.8
UterusCorpus3.05
WholeBlood3.75
Wholebrain2.85
colon3.45
pineal_day4.3
pineal_night4.24
retina4.15
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1404_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.9 ± 0.32
Basal Forebrain4.8 ± 0.4
Basal Part of Pons4.91 ± 0.3
Cerebellar Cortex4.56 ± 0.38
Cerebellar Nuclei5 ± 0.45
Claustrum4.7 ± 0.6
Epithalamus4.52 ± 0.44
Frontal Lobe4.9 ± 0.43
Globus Pallidus4.7 ± 0.48
Hypothalamus4.57 ± 0.55
Insula4.69 ± 0.51
Limbic Lobe4.75 ± 0.4
Mesencephalon4.72 ± 0.43
Myelencephalon4.78 ± 0.49
Occipital Lobe4.57 ± 0.49
Parietal Lobe4.8 ± 0.34
Pontine Tegmentum4.65 ± 0.5
Striatum4.55 ± 0.55
Subthalamus4.59 ± 0.29
Temporal Lobe4.79 ± 0.43
Thalamus4.79 ± 0.42
White Matter4.63 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kremen2CBCerebellum0.28
0.64
Kremen2CTXCerebral cortex0.29
0.47
Kremen2HIPHippocampal region0.1
0.17
Kremen2HPFHippocampal formation0.09
0.15
Kremen2HYHypothalamus0.15
0.19
Kremen2LSXLateral septal complex0.03
0
Kremen2MBMidbrain0.27
0.56
Kremen2MYMedulla0.38
0.51
Kremen2OLFOlfactory bulb0.09
0.16
Kremen2PPons0.19
0.19
Kremen2PALPallidum0.11
0.1
Kremen2RHPRetrohippocampal region0.08
0.13
Kremen2sAMYStriatum-like amygdalar nuclei0.1
0.06
Kremen2STRStriatum0.1
0.13
Kremen2STRdStriatum dorsal region0.14
0.17
Kremen2STRvStriatum ventral region0.05
0.08
Kremen2THThalamus0.33
0.43
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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