AutismKB 2.0

Annotation Detail for WDR25


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Basic Information Top
Gene Symbol:WDR25 ( MGC4645 )
Gene Full Name: WD repeat domain 25
Band: 14q32.32
Quick LinksEntrez ID:79446; OMIM: NA; Uniprot ID:WDR25_HUMAN; ENSEMBL ID: ENSG00000176473; HGNC ID: 21064
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult41 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor6 / 10312758
lymphoma4 / 7175555
non-neoplasia0 / 972500 
normal58 / 336030717
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone1 / 7165513
bone marrow0 / 488010 
brain13 / 110098911
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye6 / 21105428
heart3 / 8962633
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph4 / 4427090
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth2 / 6705229
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate1 / 1893455
salivary gland1 / 2015549
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219609_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.85
Adipocyte4.7
AdrenalCortex6.25
Adrenalgland4.05
Amygdala4.85
Appendix4.9
AtrioventricularNode3.85
BDCA4+_DentriticCells5.35
Bonemarrow4.85
BronchialEpithelialCells5.05
CD105+_Endothelial4.8
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)5
CD33+_Myeloid6.15
CD34+6.1
CD4+_Tcells5.15
CD56+_NKCells5.65
CD71+_EarlyErythroid4.45
CD8+_Tcells4.6
CardiacMyocytes6.55
Caudatenucleus4.3
Cerebellum3.85
CerebellumPeduncles5.55
CiliaryGanglion3.5
CingulateCortex4.85
Colorectaladenocarcinoma4.8
DorsalRootGanglion3.75
FetalThyroid4.65
Fetalbrain4.7
Fetalliver4.15
Fetallung3.95
GlobusPallidus3.55
Heart6.55
Hypothalamus5.15
Kidney4.2
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.6
Leukemialymphoblastic(MOLT-4)3.85
Liver7.4
Lung9.6
Lymphnode4
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)6.9
MedullaOblongata4.25
OccipitalLobe4.35
OlfactoryBulb3.7
Ovary3.2
Pancreas3.85
PancreaticIslet7.65
ParietalLobe5.1
Pituitary5.65
Placenta4.85
Pons5.15
PrefrontalCortex5.75
Prostate6.05
Salivarygland3.8
SkeletalMuscle7.9
Skin3.75
SmoothMuscle5.55
Spinalcord5.05
SubthalamicNucleus4.35
SuperiorCervicalGanglion5.65
TemporalLobe4.3
Testis4.15
TestisGermCell4.1
TestisIntersitial3.9
TestisLeydigCell4.7
TestisSeminiferousTubule3.95
Thalamus4.8
Thymus3.7
Thyroid7.4
Tongue4.7
Tonsil4.6
Trachea3.85
TrigeminalGanglion4.9
Uterus3.85
UterusCorpus4.3
WholeBlood5.15
Wholebrain5.75
colon4.75
pineal_day5.82
pineal_night5.68
retina5.7
small_intestine4.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P84202
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.71 ± 1.01
Basal Forebrain2.23 ± 0.41
Basal Part of Pons1.93 ± 0.67
Cerebellar Cortex2.51 ± 0.62
Cerebellar Nuclei2.47 ± 0.87
Claustrum2.73 ± 0.71
Epithalamus2.2 ± 0.62
Frontal Lobe2.34 ± 0.71
Globus Pallidus1.9 ± 0.65
Hypothalamus2.35 ± 0.68
Insula2.26 ± 0.62
Limbic Lobe2.19 ± 0.63
Mesencephalon2.37 ± 0.77
Myelencephalon2.32 ± 0.58
Occipital Lobe2.25 ± 0.78
Parietal Lobe2.22 ± 0.67
Pontine Tegmentum2.34 ± 0.59
Striatum2.05 ± 0.67
Subthalamus2.3 ± 0.69
Temporal Lobe2.28 ± 0.67
Thalamus2.25 ± 0.66
White Matter1.9 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr25CBCerebellum0.42
0.75
Wdr25CTXCerebral cortex0.45
0.61
Wdr25HIPHippocampal region0.52
0.59
Wdr25HPFHippocampal formation0.38
0.42
Wdr25HYHypothalamus0.05
0.03
Wdr25LSXLateral septal complex0.06
0.05
Wdr25MBMidbrain0.48
0.78
Wdr25MYMedulla0.3
0.46
Wdr25OLFOlfactory bulb0.52
1.29
Wdr25PPons0.43
0.57
Wdr25PALPallidum0.07
0.04
Wdr25RHPRetrohippocampal region0.14
0.15
Wdr25sAMYStriatum-like amygdalar nuclei0.14
0.13
Wdr25STRStriatum0.15
0.11
Wdr25STRdStriatum dorsal region0.11
0.08
Wdr25STRvStriatum ventral region0.27
0.22
Wdr25THThalamus0.1
0.19
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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