AutismKB 2.0

Annotation Detail for CDC73


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Basic Information Top
Gene Symbol:CDC73 ( C1orf28,FLJ23316,HPTJT,HRPT2,HYX )
Gene Full Name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Band: 1q31.2
Quick LinksEntrez ID:79577; OMIM: 607393; Uniprot ID:CDC73_HUMAN; ENSEMBL ID: ENSG00000134371; HGNC ID: 16783
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus25 / 56401244
neonate3 / 3109796
infant0 / 236200 
juvenile3 / 5555653
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor10 / 26384537
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor5 / 9635951
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal133 / 336030739
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer13 / 102680126
retinoblastoma3 / 4635664
skin tumor7 / 12494956
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder2 / 2975767
blood7 / 12347856
bone1 / 7165513
bone marrow5 / 48801102
brain16 / 110098914
cervix0 / 481710 
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye6 / 21105428
heart2 / 8962622
intestine6 / 23447225
kidney5 / 21177723
larynx0 / 241450 
liver6 / 20774328
lung11 / 33697432
lymph1 / 4427022
lymph node3 / 9161032
mammary gland15 / 15327197
mouth1 / 6705214
muscle5 / 10771546
nerve4 / 15768253
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta15 / 28082553
prostate20 / 189345105
salivary gland0 / 201550 
skin9 / 21057442
spleen2 / 5395237
stomach5 / 9661951
testis11 / 33044233
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus17 / 23287872
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218578_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.55
Adipocyte7.05
AdrenalCortex7.45
Adrenalgland6.2
Amygdala8.05
Appendix8.1
AtrioventricularNode6.25
BDCA4+_DentriticCells15.85
Bonemarrow7.65
BronchialEpithelialCells13.35
CD105+_Endothelial14.8
CD14+_Monocytes11.1
CD19+_BCells(neg._sel.)9.45
CD33+_Myeloid11.8
CD34+9.5
CD4+_Tcells7.8
CD56+_NKCells15.4
CD71+_EarlyErythroid13.7
CD8+_Tcells7.45
CardiacMyocytes10.45
Caudatenucleus6.55
Cerebellum5.8
CerebellumPeduncles8.35
CiliaryGanglion5.6
CingulateCortex7.35
Colorectaladenocarcinoma7.1
DorsalRootGanglion6.15
FetalThyroid7.2
Fetalbrain6.9
Fetalliver6.3
Fetallung6
GlobusPallidus5.3
Heart9.85
Hypothalamus7.05
Kidney5.85
Leukemia_chronicMyelogenousK-5626.8
Leukemia_promyelocytic-HL-606.55
Leukemialymphoblastic(MOLT-4)5.75
Liver9.6
Lung7.9
Lymphnode6.45
Lymphoma_burkitts(Daudi)9.65
Lymphoma_burkitts(Raji)10.3
MedullaOblongata6.3
OccipitalLobe6.4
OlfactoryBulb5.65
Ovary5.15
Pancreas6
PancreaticIslet7.8
ParietalLobe7.65
Pituitary8.4
Placenta7.8
Pons6.95
PrefrontalCortex9
Prostate11.45
Salivarygland6
SkeletalMuscle8.55
Skin6.55
SmoothMuscle8.65
Spinalcord7.5
SubthalamicNucleus6.55
SuperiorCervicalGanglion9.65
TemporalLobe6.65
Testis6.2
TestisGermCell5.95
TestisIntersitial6.1
TestisLeydigCell7.4
TestisSeminiferousTubule6.85
Thalamus7.45
Thymus5.65
Thyroid25.9
Tongue7.05
Tonsil7
Trachea6.15
TrigeminalGanglion7.75
Uterus8.65
UterusCorpus6.45
WholeBlood25.9
Wholebrain5.85
colon26.4
pineal_day10.68
pineal_night12.44
retina8.75
small_intestine12.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16164_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.36 ± 0.36
Basal Forebrain7.4 ± 0.13
Basal Part of Pons6.77 ± 0.23
Cerebellar Cortex7.31 ± 0.25
Cerebellar Nuclei7.16 ± 0.26
Claustrum7.31 ± 0.25
Epithalamus7.33 ± 0.45
Frontal Lobe7.05 ± 0.33
Globus Pallidus7.85 ± 0.34
Hypothalamus7.31 ± 0.26
Insula6.98 ± 0.3
Limbic Lobe7.05 ± 0.33
Mesencephalon7.34 ± 0.31
Myelencephalon7.17 ± 0.34
Occipital Lobe7.3 ± 0.24
Parietal Lobe7.15 ± 0.32
Pontine Tegmentum7.24 ± 0.28
Striatum7.19 ± 0.39
Subthalamus7.18 ± 0.23
Temporal Lobe7.08 ± 0.29
Thalamus7.2 ± 0.31
White Matter8.18 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdc73CBCerebellum2.64
3.24
Cdc73CTXCerebral cortex2.02
2.3
Cdc73HIPHippocampal region16.87
16.89
Cdc73HPFHippocampal formation14.73
14.26
Cdc73HYHypothalamus2.72
2.73
Cdc73LSXLateral septal complex0.29
0.77
Cdc73MBMidbrain0.79
1.63
Cdc73MYMedulla0.6
1
Cdc73OLFOlfactory bulb10.68
12.64
Cdc73PPons1.81
3.38
Cdc73PALPallidum3.65
6.18
Cdc73RHPRetrohippocampal region10.41
9.82
Cdc73sAMYStriatum-like amygdalar nuclei5.42
7
Cdc73STRStriatum1.76
1.92
Cdc73STRdStriatum dorsal region0.8
0.78
Cdc73STRvStriatum ventral region4.16
3.75
Cdc73THThalamus1.52
1.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CDC73_HUMAN_2 8 2 9 ADVLSVLR PRIDE
PAp00069131 17 456 472 GWPWLLPDGSPVDIFAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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