AutismKB 2.0

Annotation Detail for PPP1R3B


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Basic Information Top
Gene Symbol:PPP1R3B ( FLJ14005,FLJ34675,GL,PPP1R4 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 3B
Band: 8p23.1
Quick LinksEntrez ID:79660; OMIM: 610541; Uniprot ID:PPR3B_HUMAN; ENSEMBL ID: ENSG00000173281; HGNC ID: 14942
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus24 / 56401242
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult59 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor3 / 26384511
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal127 / 336030737
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood5 / 12347840
bone2 / 7165527
bone marrow1 / 4880120
brain17 / 110098915
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye2 / 2110549
heart9 / 89626100
intestine3 / 23447212
kidney6 / 21177728
larynx1 / 2414541
liver17 / 20774381
lung17 / 33697450
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth1 / 6705214
muscle15 / 107715139
nerve2 / 15768126
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid5 / 20539243
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate10 / 18934552
salivary gland0 / 201550 
skin10 / 21057447
spleen1 / 5395218
stomach2 / 9661920
testis5 / 33044215
thymus2 / 8113124
thyroid4 / 4747384
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus16 / 23287868
vascular5 / 5178096
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P201064
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.63 ± 0.72
Basal Forebrain4.55 ± 0.43
Basal Part of Pons3.25 ± 0.8
Cerebellar Cortex4.15 ± 0.51
Cerebellar Nuclei5.06 ± 0.54
Claustrum3.88 ± 0.94
Epithalamus4.9 ± 0.4
Frontal Lobe4.11 ± 0.63
Globus Pallidus5.89 ± 0.48
Hypothalamus4.49 ± 0.69
Insula4.01 ± 0.47
Limbic Lobe3.8 ± 0.7
Mesencephalon4.7 ± 0.51
Myelencephalon4.4 ± 0.68
Occipital Lobe4.35 ± 0.76
Parietal Lobe4.27 ± 0.81
Pontine Tegmentum4.52 ± 0.52
Striatum5.08 ± 0.69
Subthalamus4.88 ± 0.24
Temporal Lobe3.83 ± 0.7
Thalamus4.45 ± 0.62
White Matter5.68 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp1r3bCBCerebellum0.71
0.78
Ppp1r3bCTXCerebral cortex0.92
0.9
Ppp1r3bHIPHippocampal region0.41
0.29
Ppp1r3bHPFHippocampal formation1.91
1.3
Ppp1r3bHYHypothalamus0.07
0.06
Ppp1r3bLSXLateral septal complex0.24
0.23
Ppp1r3bMBMidbrain0.73
0.65
Ppp1r3bMYMedulla0.55
0.58
Ppp1r3bOLFOlfactory bulb1.15
1.08
Ppp1r3bPPons0.48
0.38
Ppp1r3bPALPallidum0.09
0.14
Ppp1r3bRHPRetrohippocampal region4.07
2.54
Ppp1r3bsAMYStriatum-like amygdalar nuclei0.1
0.08
Ppp1r3bSTRStriatum0.29
0.3
Ppp1r3bSTRdStriatum dorsal region0.12
0.1
Ppp1r3bSTRvStriatum ventral region1.12
1.18
Ppp1r3bTHThalamus0.18
0.13
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018