AutismKB 2.0

Annotation Detail for PARP8


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Basic Information Top
Gene Symbol:PARP8 ( FLJ21308,MGC42864,pART16 )
Gene Full Name: poly (ADP-ribose) polymerase family, member 8
Band: 5q11.1
Quick LinksEntrez ID:79668; OMIM: NA; Uniprot ID:PARP8_HUMAN; ENSEMBL ID: ENSG00000151883; HGNC ID: 26124
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult61 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia8 / 9584283
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal81 / 336030724
ovarian tumor5 / 7668265
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood11 / 12347889
bone1 / 7165513
bone marrow4 / 4880181
brain22 / 110098919
cervix1 / 4817120
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine4 / 23447217
kidney3 / 21177714
larynx1 / 2414541
liver4 / 20774319
lung5 / 33697414
lymph0 / 442700 
lymph node3 / 9161032
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary5 / 10205148
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta7 / 28082524
prostate3 / 18934515
salivary gland0 / 201550 
skin5 / 21057423
spleen3 / 5395255
stomach1 / 9661910
testis13 / 33044239
thymus14 / 81131172
thyroid3 / 4747363
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus10 / 23287842
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219033_at
Cell line Expression level Expression bar
721_B_lymphoblasts60
Adipocyte10.6
AdrenalCortex25.55
Adrenalgland17.05
Amygdala18.95
Appendix45.45
AtrioventricularNode19.8
BDCA4+_DentriticCells52.1
Bonemarrow27.75
BronchialEpithelialCells18.4
CD105+_Endothelial7.85
CD14+_Monocytes87.3
CD19+_BCells(neg._sel.)29
CD33+_Myeloid147.85
CD34+14.95
CD4+_Tcells161.1
CD56+_NKCells381.55
CD71+_EarlyErythroid11.6
CD8+_Tcells227.35
CardiacMyocytes25.35
Caudatenucleus18.5
Cerebellum16.4
CerebellumPeduncles25.05
CiliaryGanglion21.25
CingulateCortex22.25
Colorectaladenocarcinoma18.3
DorsalRootGanglion20.25
FetalThyroid38.75
Fetalbrain19.35
Fetalliver17
Fetallung15.65
GlobusPallidus14.9
Heart26.5
Hypothalamus17.25
Kidney20.65
Leukemia_chronicMyelogenousK-56216.7
Leukemia_promyelocytic-HL-6017.15
Leukemialymphoblastic(MOLT-4)15.4
Liver29
Lung17.5
Lymphnode55.35
Lymphoma_burkitts(Daudi)33.5
Lymphoma_burkitts(Raji)29.9
MedullaOblongata23.7
OccipitalLobe17.6
OlfactoryBulb14.45
Ovary15
Pancreas14
PancreaticIslet21.25
ParietalLobe24.8
Pituitary29.65
Placenta12.4
Pons20.4
PrefrontalCortex20
Prostate21.7
Salivarygland32.35
SkeletalMuscle34.1
Skin16.75
SmoothMuscle22.6
Spinalcord22.4
SubthalamicNucleus18.8
SuperiorCervicalGanglion44.05
TemporalLobe16.65
Testis19.05
TestisGermCell15.9
TestisIntersitial21.85
TestisLeydigCell21.4
TestisSeminiferousTubule17.7
Thalamus20.4
Thymus14.35
Thyroid46.35
Tongue36.65
Tonsil25.5
Trachea18.4
TrigeminalGanglion31.75
Uterus14.25
UterusCorpus23.55
WholeBlood240.75
Wholebrain15.65
colon15.8
pineal_day17.2
pineal_night15.08
retina20.975
small_intestine15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7981_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.41 ± 0.49
Basal Forebrain6.08 ± 0.3
Basal Part of Pons5.63 ± 0.3
Cerebellar Cortex5.84 ± 0.32
Cerebellar Nuclei5.73 ± 0.38
Claustrum6.67 ± 0.63
Epithalamus6.28 ± 0.24
Frontal Lobe6.42 ± 0.43
Globus Pallidus6.43 ± 0.54
Hypothalamus6.11 ± 0.2
Insula6.39 ± 0.16
Limbic Lobe6.85 ± 0.41
Mesencephalon6.28 ± 0.51
Myelencephalon6.3 ± 0.53
Occipital Lobe6.53 ± 0.38
Parietal Lobe6.45 ± 0.43
Pontine Tegmentum6.44 ± 0.4
Striatum5.56 ± 0.84
Subthalamus6.03 ± 0.2
Temporal Lobe6.39 ± 0.31
Thalamus6.37 ± 0.47
White Matter4.99 ± 0.67
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Parp8CBCerebellum3.3
3.51
Parp8CTXCerebral cortex4.62
3.29
Parp8HIPHippocampal region15.43
32.16
Parp8HPFHippocampal formation13.91
21.54
Parp8HYHypothalamus11.56
8.71
Parp8LSXLateral septal complex5.82
3.77
Parp8MBMidbrain9.24
7.63
Parp8MYMedulla11.42
11.03
Parp8OLFOlfactory bulb6.75
4.9
Parp8PPons8.14
7.56
Parp8PALPallidum8.27
6.87
Parp8RHPRetrohippocampal region12.17
10.59
Parp8sAMYStriatum-like amygdalar nuclei8.79
6.43
Parp8STRStriatum2.36
1.77
Parp8STRdStriatum dorsal region0.83
0.74
Parp8STRvStriatum ventral region2.62
1.85
Parp8THThalamus1.96
1.49
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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