AutismKB 2.0

Annotation Detail for LRRK1


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Basic Information Top
Gene Symbol:LRRK1 ( FLJ23119,FLJ27465,KIAA1790,RIPK6,Roco1 )
Gene Full Name: leucine-rich repeat kinase 1
Band: 15q26.3
Quick LinksEntrez ID:79705; OMIM: 610986; Uniprot ID:LRRK1_HUMAN; ENSEMBL ID: ENSG00000154237; HGNC ID: 18608
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus10 / 56401217
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult48 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia1 / 9725010
normal72 / 336030721
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood4 / 12347832
bone1 / 7165513
bone marrow2 / 4880140
brain8 / 11009897
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye2 / 2110549
heart5 / 8962655
intestine6 / 23447225
kidney2 / 2117779
larynx2 / 2414582
liver1 / 2077434
lung9 / 33697426
lymph3 / 4427067
lymph node24 / 91610261
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary2 / 10205119
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate2 / 18934510
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach0 / 966190 
testis5 / 33044215
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219441_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.4
Adipocyte7.4
AdrenalCortex7.95
Adrenalgland6.3
Amygdala7.7
Appendix7.7
AtrioventricularNode6.55
BDCA4+_DentriticCells15.7
Bonemarrow7.5
BronchialEpithelialCells6.4
CD105+_Endothelial7.3
CD14+_Monocytes8
CD19+_BCells(neg._sel.)11.3
CD33+_Myeloid9.6
CD34+9.6
CD4+_Tcells7.75
CD56+_NKCells8.8
CD71+_EarlyErythroid7.1
CD8+_Tcells7
CardiacMyocytes9.55
Caudatenucleus6.75
Cerebellum6.1
CerebellumPeduncles8.65
CiliaryGanglion6
CingulateCortex7.75
Colorectaladenocarcinoma7.15
DorsalRootGanglion6.25
FetalThyroid7.25
Fetalbrain7.5
Fetalliver6.45
Fetallung5.9
GlobusPallidus5.6
Heart9.4
Hypothalamus7.95
Kidney6.2
Leukemia_chronicMyelogenousK-5626.5
Leukemia_promyelocytic-HL-6010.5
Leukemialymphoblastic(MOLT-4)5.85
Liver9.85
Lung8.25
Lymphnode7.85
Lymphoma_burkitts(Daudi)22.2
Lymphoma_burkitts(Raji)18.1
MedullaOblongata7.05
OccipitalLobe7.2
OlfactoryBulb5.85
Ovary6.55
Pancreas6.15
PancreaticIslet8.05
ParietalLobe8.1
Pituitary8.75
Placenta7.75
Pons9.9
PrefrontalCortex8.75
Prostate9.7
Salivarygland6.9
SkeletalMuscle9.35
Skin7.15
SmoothMuscle8.45
Spinalcord7.95
SubthalamicNucleus6.95
SuperiorCervicalGanglion9.05
TemporalLobe6.95
Testis6.45
TestisGermCell6.2
TestisIntersitial6.3
TestisLeydigCell7.55
TestisSeminiferousTubule9.1
Thalamus7.7
Thymus5.7
Thyroid9.05
Tongue7.75
Tonsil10.3
Trachea8.5
TrigeminalGanglion8.2
Uterus6.1
UterusCorpus6.9
WholeBlood8.15
Wholebrain6.15
colon7.55
pineal_day8.3
pineal_night8.12
retina9.1
small_intestine7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7988_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.77 ± 0.56
Basal Forebrain3.01 ± 0.46
Basal Part of Pons3.18 ± 0.4
Cerebellar Cortex3.36 ± 0.65
Cerebellar Nuclei3.17 ± 0.3
Claustrum3.21 ± 0.81
Epithalamus3.09 ± 0.73
Frontal Lobe3.29 ± 0.57
Globus Pallidus3.2 ± 0.62
Hypothalamus3.07 ± 0.61
Insula3.23 ± 0.64
Limbic Lobe3.43 ± 0.56
Mesencephalon3.25 ± 0.74
Myelencephalon3.31 ± 0.6
Occipital Lobe3.41 ± 0.61
Parietal Lobe3.47 ± 0.55
Pontine Tegmentum3.26 ± 0.68
Striatum2.61 ± 0.71
Subthalamus3.14 ± 0.78
Temporal Lobe3.47 ± 0.56
Thalamus3.03 ± 0.57
White Matter2.46 ± 0.77
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrrk1CBCerebellum21.94
33.03
Lrrk1CTXCerebral cortex14.82
11.73
Lrrk1HIPHippocampal region2.7
2.36
Lrrk1HPFHippocampal formation2.96
2.59
Lrrk1HYHypothalamus1.83
1.62
Lrrk1LSXLateral septal complex1.27
0.95
Lrrk1MBMidbrain6.66
6.85
Lrrk1MYMedulla11.74
12.23
Lrrk1OLFOlfactory bulb8.6
7.47
Lrrk1PPons6.39
8.05
Lrrk1PALPallidum2.3
1.62
Lrrk1RHPRetrohippocampal region3.43
2.98
Lrrk1sAMYStriatum-like amygdalar nuclei0.83
0.55
Lrrk1STRStriatum2.58
1.74
Lrrk1STRdStriatum dorsal region2.44
1.66
Lrrk1STRvStriatum ventral region4.37
2.75
Lrrk1THThalamus2.75
2.33
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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