AutismKB 2.0

Annotation Detail for IPO4


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Basic Information Top
Gene Symbol:IPO4 ( FLJ23338,Imp4,MGC131665 )
Gene Full Name: importin 4
Band: 14q12
Quick LinksEntrez ID:79711; OMIM: NA; Uniprot ID:IPO4_HUMAN; ENSEMBL ID: ENSG00000196497; HGNC ID: 19426
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst15 / 62319240
fetus28 / 56401249
neonate2 / 3109764
infant2 / 2362084
juvenile13 / 55556233
adult149 / 193912176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor37 / 94178392
cervical tumor5 / 34366145
chondrosarcoma9 / 82823108
colorectal tumor6 / 11424652
esophageal tumor5 / 17290289
gastrointestinal tumor13 / 119369108
germ cell tumor64 / 263845242
glioma3 / 10688328
head and neck tumor30 / 136302220
kidney tumor6 / 6895987
leukemia10 / 95842104
liver tumor11 / 96359114
lung tumor8 / 10312777
lymphoma12 / 71755167
non-neoplasia2 / 9725020
normal192 / 336030757
ovarian tumor5 / 7668265
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS34 / 125680270
prostate cancer13 / 102680126
retinoblastoma8 / 46356172
skin tumor30 / 124949240
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites6 / 40015149
bladder2 / 2975767
blood6 / 12347848
bone5 / 7165569
bone marrow6 / 48801122
brain74 / 110098967
cervix13 / 48171269
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue31 / 215722143
esophagus5 / 20209247
eye9 / 21105442
heart1 / 8962611
intestine19 / 23447281
kidney10 / 21177747
larynx1 / 2414541
liver11 / 20774352
lung21 / 33697462
lymph6 / 44270135
lymph node0 / 916100 
mammary gland38 / 153271247
mouth20 / 67052298
muscle11 / 107715102
nerve0 / 157680 
ovary7 / 10205168
pancreas22 / 214812102
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta39 / 280825138
prostate16 / 18934584
salivary gland6 / 20155297
skin36 / 210574170
spleen4 / 5395274
stomach5 / 9661951
testis205 / 330442620
thymus5 / 8113161
thyroid4 / 4747384
tonsil0 / 169990 
trachea25 / 52413476
umbilical cord0 / 136800 
uterus14 / 23287860
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218305_at
Cell line Expression level Expression bar
721_B_lymphoblasts150
Adipocyte35.9
AdrenalCortex40.4
Adrenalgland37.4
Amygdala24.9
Appendix47.55
AtrioventricularNode32.45
BDCA4+_DentriticCells44.3
Bonemarrow35.95
BronchialEpithelialCells46.9
CD105+_Endothelial36.45
CD14+_Monocytes30.55
CD19+_BCells(neg._sel.)20.8
CD33+_Myeloid38.15
CD34+64.15
CD4+_Tcells38.35
CD56+_NKCells31.2
CD71+_EarlyErythroid23.35
CD8+_Tcells27.2
CardiacMyocytes73.6
Caudatenucleus29.5
Cerebellum33.15
CerebellumPeduncles38.6
CiliaryGanglion27.75
CingulateCortex33.8
Colorectaladenocarcinoma48.2
DorsalRootGanglion28.35
FetalThyroid36.65
Fetalbrain34.15
Fetalliver29.75
Fetallung31.2
GlobusPallidus25.4
Heart56.5
Hypothalamus27.1
Kidney45.45
Leukemia_chronicMyelogenousK-56270.55
Leukemia_promyelocytic-HL-6062.95
Leukemialymphoblastic(MOLT-4)33.95
Liver70.9
Lung41.2
Lymphnode31.15
Lymphoma_burkitts(Daudi)73.95
Lymphoma_burkitts(Raji)90
MedullaOblongata34.9
OccipitalLobe22.45
OlfactoryBulb27.5
Ovary23.45
Pancreas60.45
PancreaticIslet61.05
ParietalLobe40.5
Pituitary50.1
Placenta32.35
Pons33.55
PrefrontalCortex30.95
Prostate50.75
Salivarygland27.5
SkeletalMuscle84.15
Skin28.8
SmoothMuscle46.15
Spinalcord36.2
SubthalamicNucleus32.85
SuperiorCervicalGanglion54.85
TemporalLobe29.15
Testis139.1
TestisGermCell105.85
TestisIntersitial150.6
TestisLeydigCell99
TestisSeminiferousTubule84.6
Thalamus29.55
Thymus31.95
Thyroid55.1
Tongue55.8
Tonsil36.2
Trachea34.9
TrigeminalGanglion39.9
Uterus36
UterusCorpus34.15
WholeBlood33.35
Wholebrain23.8
colon18.5
pineal_day28.72
pineal_night26.52
retina31.475
small_intestine17.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5211_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.54 ± 0.66
Basal Forebrain3.48 ± 0.73
Basal Part of Pons3.62 ± 0.52
Cerebellar Cortex2.94 ± 0.56
Cerebellar Nuclei3.02 ± 0.46
Claustrum3.9 ± 1.05
Epithalamus2.91 ± 0.67
Frontal Lobe3.23 ± 0.69
Globus Pallidus4.14 ± 0.45
Hypothalamus2.84 ± 0.69
Insula2.7 ± 0.6
Limbic Lobe3.51 ± 0.74
Mesencephalon3.4 ± 0.7
Myelencephalon3.41 ± 0.74
Occipital Lobe3.38 ± 0.87
Parietal Lobe3.26 ± 0.77
Pontine Tegmentum3.11 ± 0.75
Striatum3.56 ± 0.7
Subthalamus3.09 ± 0.34
Temporal Lobe3.25 ± 0.72
Thalamus3.36 ± 0.58
White Matter3.67 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ipo4CBCerebellum34.23
54.6
Ipo4CTXCerebral cortex100
96.48
Ipo4HIPHippocampal region63.12
99.58
Ipo4HPFHippocampal formation84.19
100
Ipo4HYHypothalamus81.14
65.87
Ipo4LSXLateral septal complex100
86.45
Ipo4MBMidbrain79.81
71.67
Ipo4MYMedulla81.91
95.65
Ipo4OLFOlfactory bulb98.14
83.37
Ipo4PPons79.37
84.14
Ipo4PALPallidum78.15
62.27
Ipo4RHPRetrohippocampal region100
93.86
Ipo4sAMYStriatum-like amygdalar nuclei83.64
57.18
Ipo4STRStriatum78.69
48.65
Ipo4STRdStriatum dorsal region70.38
41.89
Ipo4STRvStriatum ventral region83.75
54.29
Ipo4THThalamus90.06
79.84
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IPO4_HUMAN_1 11 1 11 MESAGLEQLLR PRIDE
IPO4_HUMAN_1004 22 1004 1025 LFSFLYQSSPDQVIDVAPELLR PRIDE
IPO4_HUMAN_12 9 12 20 ELLLPDTER PRIDE
IPO4_HUMAN_183 18 183 200 TLTTMAPYLSTEDVPLAR PRIDE
IPO4_HUMAN_24 10 24 33 ATEQLQIVLR PRIDE
IPO4_HUMAN_267 10 267 276 ILCCLTFLVK PRIDE
IPO4_HUMAN_349 14 349 362 LCPQLMPMLEEALR PRIDE
IPO4_HUMAN_434 11 434 444 EVMPLLLAYLK PRIDE
IPO4_HUMAN_435 11 435 445 EVMPLLLAYLK PRIDE
IPO4_HUMAN_446 12 446 457 SVPLGHTHHLAK PRIDE
IPO4_HUMAN_458 15 458 472 ACYALENFVENLGPK PRIDE
IPO4_HUMAN_472 17 472 488 VQPYLPELMECMLQLLR PRIDE
IPO4_HUMAN_55 8 55 62 QFAAVLTR PRIDE
IPO4_HUMAN_716 15 716 730 AAHEALGQFCCALHK PRIDE
IPO4_HUMAN_72 6 72 77 LAAEQR PRIDE
IPO4_HUMAN_731 20 731 750 ACQSCPSEPNTAALQAALAR PRIDE
IPO4_HUMAN_751 11 751 761 VVPSYMQAVNR PRIDE
IPO4_HUMAN_765 15 765 779 QVVMAVLEALTGVLR PRIDE
IPO4_HUMAN_781 12 781 792 SCGTLTLKPPGR PRIDE
IPO4_HUMAN_793 9 793 801 LAELCGVLK PRIDE
IPO4_HUMAN_82 9 82 90 SLILTALQR PRIDE
IPO4_HUMAN_917 24 917 940 SNAIFGMGVLAEHGGHPAQEHFPK PRIDE
IPO4_HUMAN_940 11 940 950 LLGLLFPLLAR PRIDE
IPO4_HUMAN_993 11 993 1003 EDLEEWVTIGR PRIDE
PAp00005081 10 705 714 LLECPHLNVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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