AutismKB 2.0

Annotation Detail for WDR59


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Basic Information Top
Gene Symbol:WDR59 ( FLJ12270,MGC11230 )
Gene Full Name: WD repeat domain 59
Band: 16q23.1
Quick LinksEntrez ID:79726; OMIM: NA; Uniprot ID:WDR59_HUMAN; ENSEMBL ID: ENSG00000103091; HGNC ID: 25706
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst8 / 62319128
fetus44 / 56401278
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult71 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma7 / 8282384
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor6 / 26384522
glioma7 / 10688365
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia7 / 9584273
liver tumor1 / 9635910
lung tumor5 / 10312748
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal180 / 336030753
ovarian tumor3 / 7668239
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder1 / 2975733
blood6 / 12347848
bone5 / 7165569
bone marrow1 / 4880120
brain36 / 110098932
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye25 / 211054118
heart5 / 8962655
intestine8 / 23447234
kidney7 / 21177733
larynx0 / 241450 
liver6 / 20774328
lung17 / 33697450
lymph1 / 4427022
lymph node3 / 9161032
mammary gland9 / 15327158
mouth2 / 6705229
muscle3 / 10771527
nerve0 / 157680 
ovary4 / 10205139
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta8 / 28082528
prostate3 / 18934515
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach4 / 9661941
testis19 / 33044257
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219586_at
Cell line Expression level Expression bar
721_B_lymphoblasts4
Adipocyte3.15
AdrenalCortex3.25
Adrenalgland2.65
Amygdala3.35
Appendix3.2
AtrioventricularNode2.4
BDCA4+_DentriticCells3.55
Bonemarrow3.1
BronchialEpithelialCells3.15
CD105+_Endothelial3.15
CD14+_Monocytes3.4
CD19+_BCells(neg._sel.)3.4
CD33+_Myeloid4.05
CD34+4.05
CD4+_Tcells3.5
CD56+_NKCells3.8
CD71+_EarlyErythroid2.95
CD8+_Tcells3.1
CardiacMyocytes3.95
Caudatenucleus2.8
Cerebellum2.55
CerebellumPeduncles3.5
CiliaryGanglion2.2
CingulateCortex3.25
Colorectaladenocarcinoma3.15
DorsalRootGanglion2.4
FetalThyroid3.05
Fetalbrain3.15
Fetalliver2.7
Fetallung2.65
GlobusPallidus2.3
Heart4
Hypothalamus3.45
Kidney2.5
Leukemia_chronicMyelogenousK-5622.85
Leukemia_promyelocytic-HL-602.8
Leukemialymphoblastic(MOLT-4)2.55
Liver4.15
Lung3.5
Lymphnode2.7
Lymphoma_burkitts(Daudi)4
Lymphoma_burkitts(Raji)4.4
MedullaOblongata2.9
OccipitalLobe2.85
OlfactoryBulb2.5
Ovary2.05
Pancreas2.5
PancreaticIslet3.35
ParietalLobe3.3
Pituitary3.7
Placenta3.3
Pons3
PrefrontalCortex3.95
Prostate3.7
Salivarygland2.5
SkeletalMuscle3.7
Skin2.35
SmoothMuscle3.6
Spinalcord3.4
SubthalamicNucleus2.85
SuperiorCervicalGanglion3.55
TemporalLobe2.9
Testis2.7
TestisGermCell2.6
TestisIntersitial2.65
TestisLeydigCell3.15
TestisSeminiferousTubule2.7
Thalamus3.2
Thymus2.5
Thyroid4
Tongue3.1
Tonsil3.05
Trachea2.65
TrigeminalGanglion3.2
Uterus2.6
UterusCorpus2.8
WholeBlood3.5
Wholebrain2.7
colon3.15
pineal_day3.96
pineal_night3.88
retina3.825
small_intestine3.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P206856
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.92 ± 0.55
Basal Forebrain6.42 ± 0.25
Basal Part of Pons6.12 ± 0.35
Cerebellar Cortex6.49 ± 0.37
Cerebellar Nuclei6.35 ± 0.38
Claustrum5.67 ± 0.72
Epithalamus6.23 ± 0.56
Frontal Lobe6.23 ± 0.44
Globus Pallidus6.37 ± 0.27
Hypothalamus6.6 ± 0.5
Insula6.34 ± 0.27
Limbic Lobe6.12 ± 0.44
Mesencephalon6.32 ± 0.3
Myelencephalon6.25 ± 0.46
Occipital Lobe6.32 ± 0.49
Parietal Lobe6.11 ± 0.43
Pontine Tegmentum6.28 ± 0.56
Striatum6.2 ± 0.38
Subthalamus6.04 ± 0.49
Temporal Lobe6.36 ± 0.38
Thalamus6.28 ± 0.43
White Matter7.5 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr59CBCerebellum10.27
12.06
Wdr59CTXCerebral cortex5.13
3.77
Wdr59HIPHippocampal region7.88
7.16
Wdr59HPFHippocampal formation7.35
6.08
Wdr59HYHypothalamus1.37
1.13
Wdr59LSXLateral septal complex0.54
0.44
Wdr59MBMidbrain4.23
3.99
Wdr59MYMedulla11.87
13.19
Wdr59OLFOlfactory bulb4.19
3.15
Wdr59PPons7.38
8.22
Wdr59PALPallidum3.57
2.95
Wdr59RHPRetrohippocampal region6.76
4.75
Wdr59sAMYStriatum-like amygdalar nuclei1.04
0.87
Wdr59STRStriatum2.94
2.34
Wdr59STRdStriatum dorsal region3.81
3.16
Wdr59STRvStriatum ventral region1.79
1.14
Wdr59THThalamus4.72
3.79
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00031808 14 647 660 VIIQDIACLLPVHK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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