AutismKB 2.0

Annotation Detail for ZNF408


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Basic Information Top
Gene Symbol:ZNF408 ( FLJ12827 )
Gene Full Name: zinc finger protein 408
Band: 11p11.2
Quick LinksEntrez ID:79797; OMIM: NA; Uniprot ID:ZN408_HUMAN; ENSEMBL ID: ENSG00000175213; HGNC ID: 20041
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus20 / 56401235
neonate3 / 3109796
infant0 / 236200 
juvenile6 / 55556107
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor24 / 26384590
glioma9 / 10688384
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor6 / 9635962
lung tumor12 / 103127116
lymphoma12 / 71755167
non-neoplasia5 / 9725051
normal138 / 336030741
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland4 / 33197120
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow1 / 4880120
brain70 / 110098963
cervix0 / 481710 
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus2 / 2020998
eye7 / 21105433
heart3 / 8962633
intestine8 / 23447234
kidney3 / 21177714
larynx0 / 241450 
liver8 / 20774338
lung13 / 33697438
lymph4 / 4427090
lymph node4 / 9161043
mammary gland4 / 15327126
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate4 / 18934521
salivary gland3 / 20155148
skin9 / 21057442
spleen4 / 5395274
stomach2 / 9661920
testis12 / 33044236
thymus13 / 81131160
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus16 / 23287868
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219224_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.65
Adipocyte6.8
AdrenalCortex6.9
Adrenalgland5.65
Amygdala6.9
Appendix7
AtrioventricularNode5
BDCA4+_DentriticCells12.3
Bonemarrow12.7
BronchialEpithelialCells6.2
CD105+_Endothelial6.7
CD14+_Monocytes8.1
CD19+_BCells(neg._sel.)14.25
CD33+_Myeloid8.65
CD34+19.55
CD4+_Tcells7.3
CD56+_NKCells10.6
CD71+_EarlyErythroid8.2
CD8+_Tcells6.6
CardiacMyocytes8.6
Caudatenucleus6.65
Cerebellum5.4
CerebellumPeduncles7.55
CiliaryGanglion4.65
CingulateCortex7.55
Colorectaladenocarcinoma6.75
DorsalRootGanglion5
FetalThyroid6.15
Fetalbrain6.65
Fetalliver6.65
Fetallung5.65
GlobusPallidus4.8
Heart13.95
Hypothalamus7.3
Kidney5.35
Leukemia_chronicMyelogenousK-5626.05
Leukemia_promyelocytic-HL-606.25
Leukemialymphoblastic(MOLT-4)5.95
Liver16.1
Lung13.95
Lymphnode5.8
Lymphoma_burkitts(Daudi)8.45
Lymphoma_burkitts(Raji)9.55
MedullaOblongata6.15
OccipitalLobe5.95
OlfactoryBulb5.45
Ovary4.4
Pancreas5.3
PancreaticIslet7.45
ParietalLobe7.05
Pituitary7.8
Placenta6.9
Pons6.35
PrefrontalCortex8.2
Prostate7.9
Salivarygland5.1
SkeletalMuscle8
Skin5.1
SmoothMuscle8.1
Spinalcord7.2
SubthalamicNucleus5.95
SuperiorCervicalGanglion7.85
TemporalLobe6.05
Testis5.85
TestisGermCell6.25
TestisIntersitial5.6
TestisLeydigCell6.45
TestisSeminiferousTubule5.75
Thalamus6.8
Thymus5.6
Thyroid8.5
Tongue6.35
Tonsil6.4
Trachea5.5
TrigeminalGanglion6.5
Uterus10.3
UterusCorpus5.9
WholeBlood7.6
Wholebrain5.75
colon6.65
pineal_day8.22
pineal_night8.16
retina8.175
small_intestine6.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1485_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.4 ± 1.16
Basal Forebrain1.9 ± 0.27
Basal Part of Pons1.92 ± 0.76
Cerebellar Cortex2.43 ± 0.64
Cerebellar Nuclei2.41 ± 0.71
Claustrum2.64 ± 0.86
Epithalamus1.66 ± 0.69
Frontal Lobe1.95 ± 0.75
Globus Pallidus2.12 ± 0.71
Hypothalamus1.97 ± 0.72
Insula1.97 ± 0.9
Limbic Lobe2.09 ± 0.85
Mesencephalon2.11 ± 0.79
Myelencephalon2.12 ± 0.77
Occipital Lobe2 ± 0.96
Parietal Lobe2.14 ± 0.91
Pontine Tegmentum2.13 ± 0.78
Striatum2.04 ± 0.8
Subthalamus2.05 ± 0.69
Temporal Lobe2.06 ± 0.84
Thalamus2.1 ± 0.79
White Matter2.07 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfp408CBCerebellum0.84
1.09
Zfp408CTXCerebral cortex1.38
1.35
Zfp408HIPHippocampal region1.2
1.29
Zfp408HPFHippocampal formation0.94
1.17
Zfp408HYHypothalamus0.32
0.4
Zfp408LSXLateral septal complex0.42
0.8
Zfp408MBMidbrain0.41
0.54
Zfp408MYMedulla2.07
2.98
Zfp408OLFOlfactory bulb2.18
1.64
Zfp408PPons0.68
0.82
Zfp408PALPallidum0.34
0.31
Zfp408RHPRetrohippocampal region0.49
1.02
Zfp408sAMYStriatum-like amygdalar nuclei0.21
0.21
Zfp408STRStriatum0.47
0.72
Zfp408STRdStriatum dorsal region0.5
0.65
Zfp408STRvStriatum ventral region0.46
1.01
Zfp408THThalamus0.39
0.44
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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