AutismKB 2.0

Annotation Detail for SHCBP1


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Basic Information Top
Gene Symbol:SHCBP1 ( FLJ22009,MGC26900,PAL )
Gene Full Name: SHC SH2-domain binding protein 1
Band: 16q11.2
Quick LinksEntrez ID:79801; OMIM: 611027; Uniprot ID:SHCBP_HUMAN; ENSEMBL ID: ENSG00000171241; HGNC ID: 29547
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus11 / 56401219
neonate4 / 31097128
infant1 / 2362042
juvenile4 / 5555671
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal59 / 336030717
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow1 / 4880120
brain12 / 110098910
cervix2 / 4817141
connective tissue5 / 14925533
ear4 / 16212246
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney8 / 21177737
larynx0 / 241450 
liver5 / 20774324
lung5 / 33697414
lymph0 / 442700 
lymph node3 / 9161032
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate4 / 18934521
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus10 / 81131123
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219493_at
Cell line Expression level Expression bar
721_B_lymphoblasts111.05
Adipocyte7.05
AdrenalCortex10.2
Adrenalgland6.55
Amygdala6.65
Appendix9.45
AtrioventricularNode10.15
BDCA4+_DentriticCells12.8
Bonemarrow8.7
BronchialEpithelialCells8
CD105+_Endothelial124.45
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)7.35
CD33+_Myeloid10.15
CD34+37.55
CD4+_Tcells7.15
CD56+_NKCells9.15
CD71+_EarlyErythroid149.15
CD8+_Tcells6.7
CardiacMyocytes18.95
Caudatenucleus6.45
Cerebellum5.9
CerebellumPeduncles9.55
CiliaryGanglion6.65
CingulateCortex7.6
Colorectaladenocarcinoma8.5
DorsalRootGanglion7.6
FetalThyroid7.45
Fetalbrain7.1
Fetalliver6.8
Fetallung5.35
GlobusPallidus5.85
Heart11.6
Hypothalamus7.7
Kidney6.55
Leukemia_chronicMyelogenousK-5627.35
Leukemia_promyelocytic-HL-6012.9
Leukemialymphoblastic(MOLT-4)17.85
Liver12.55
Lung7.85
Lymphnode6
Lymphoma_burkitts(Daudi)20.35
Lymphoma_burkitts(Raji)12.45
MedullaOblongata6.2
OccipitalLobe6.15
OlfactoryBulb5.5
Ovary5.65
Pancreas6.2
PancreaticIslet7.7
ParietalLobe8.65
Pituitary8.45
Placenta7.3
Pons7.5
PrefrontalCortex8.75
Prostate7.9
Salivarygland6.25
SkeletalMuscle10.1
Skin9.3
SmoothMuscle11.8
Spinalcord7.65
SubthalamicNucleus7.3
SuperiorCervicalGanglion11.3
TemporalLobe7.1
Testis6.2
TestisGermCell6.05
TestisIntersitial6.45
TestisLeydigCell7.8
TestisSeminiferousTubule6.3
Thalamus7.6
Thymus5.6
Thyroid8.95
Tongue8.65
Tonsil7.6
Trachea5.8
TrigeminalGanglion11.45
Uterus5.65
UterusCorpus8.2
WholeBlood8
Wholebrain5.85
colon7.7
pineal_day8.6
pineal_night8.28
retina8.9
small_intestine6.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12976_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.16 ± 0.45
Basal Forebrain2.59 ± 0.51
Basal Part of Pons2.12 ± 0.72
Cerebellar Cortex2.87 ± 0.64
Cerebellar Nuclei2.42 ± 0.81
Claustrum2.99 ± 0.74
Epithalamus2.63 ± 0.91
Frontal Lobe2.15 ± 0.85
Globus Pallidus2.35 ± 0.81
Hypothalamus1.81 ± 0.62
Insula2.18 ± 0.92
Limbic Lobe2.67 ± 0.94
Mesencephalon2.35 ± 0.82
Myelencephalon2.39 ± 0.74
Occipital Lobe2.46 ± 0.65
Parietal Lobe2.28 ± 0.98
Pontine Tegmentum2.48 ± 0.9
Striatum3.52 ± 0.86
Subthalamus2.09 ± 0.8
Temporal Lobe2.36 ± 0.74
Thalamus2.09 ± 0.73
White Matter2.27 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Shcbp1CBCerebellum1.56
1.84
Shcbp1CTXCerebral cortex1.75
1.58
Shcbp1HIPHippocampal region1.26
1.38
Shcbp1HPFHippocampal formation1.11
1.15
Shcbp1HYHypothalamus0.24
0.22
Shcbp1LSXLateral septal complex0.21
0.34
Shcbp1MBMidbrain0.9
1.19
Shcbp1MYMedulla1.79
2.17
Shcbp1OLFOlfactory bulb3.84
2.59
Shcbp1PPons1.22
2.12
Shcbp1PALPallidum0.27
0.25
Shcbp1RHPRetrohippocampal region0.7
0.6
Shcbp1sAMYStriatum-like amygdalar nuclei0.16
0.12
Shcbp1STRStriatum0.66
0.61
Shcbp1STRdStriatum dorsal region0.74
0.75
Shcbp1STRvStriatum ventral region0.56
0.36
Shcbp1THThalamus0.62
0.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00078424 15 208 222 SWDEEEEDEYDYFVR Peptide Atlas
SHCBP_HUMAN_2 19 2 20 ADGSLTGGGLEAAAMAPER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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