AutismKB 2.0

Annotation Detail for TTC21B


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Basic Information Top
Gene Symbol:TTC21B ( FLJ11457,THM1 )
Gene Full Name: tetratricopeptide repeat domain 21B
Band: 2q24.3
Quick LinksEntrez ID:79809; OMIM: 612014; Uniprot ID:TT21B_HUMAN; ENSEMBL ID: ENSG00000123607; HGNC ID: 25660
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult22 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal55 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood2 / 12347816
bone1 / 7165513
bone marrow0 / 488010 
brain8 / 11009897
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye3 / 21105414
heart4 / 8962644
intestine0 / 2344720 
kidney4 / 21177718
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph0 / 442700 
lymph node3 / 9161032
mammary gland3 / 15327119
mouth2 / 6705229
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta3 / 28082510
prostate3 / 18934515
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach2 / 9661920
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5093_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.6 ± 0.38
Basal Forebrain7.48 ± 0.22
Basal Part of Pons7.6 ± 0.36
Cerebellar Cortex7.79 ± 0.49
Cerebellar Nuclei7.59 ± 0.36
Claustrum7.47 ± 0.41
Epithalamus8.15 ± 0.49
Frontal Lobe7.48 ± 0.33
Globus Pallidus7.45 ± 0.25
Hypothalamus7.63 ± 0.21
Insula7.44 ± 0.27
Limbic Lobe7.72 ± 0.4
Mesencephalon7.76 ± 0.46
Myelencephalon7.61 ± 0.4
Occipital Lobe8.2 ± 0.43
Parietal Lobe7.72 ± 0.32
Pontine Tegmentum7.63 ± 0.3
Striatum7.76 ± 0.38
Subthalamus7.97 ± 0.08
Temporal Lobe7.5 ± 0.38
Thalamus7.48 ± 0.25
White Matter7.77 ± 0.21
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00623401 22 811 832 VLQHALAHEPVNELSALMEDGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018