AutismKB 2.0

Annotation Detail for METTL8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:METTL8 ( FLJ13334,FLJ13984,FLJ31054,FLJ42098,FLJ77788,TIP )
Gene Full Name: methyltransferase like 8
Band: 2q31.1
Quick LinksEntrez ID:79828; OMIM: 609525; Uniprot ID:A8K7U3_HUMAN; ENSEMBL ID: ENSG00000123600; HGNC ID: 25856
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus11 / 56401219
neonate2 / 3109764
infant1 / 2362042
juvenile4 / 5555671
adult33 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor3 / 17290173
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor8 / 9635983
lung tumor2 / 10312719
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal63 / 336030718
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood4 / 12347832
bone4 / 7165555
bone marrow2 / 4880140
brain12 / 110098910
cervix1 / 4817120
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus3 / 20209148
eye2 / 2110549
heart4 / 8962644
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver9 / 20774343
lung6 / 33697417
lymph1 / 4427022
lymph node1 / 9161010
mammary gland2 / 15327113
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate5 / 18934526
salivary gland0 / 201550 
skin8 / 21057437
spleen2 / 5395237
stomach1 / 9661910
testis8 / 33044224
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220007_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.45
Adipocyte6.55
AdrenalCortex7.75
Adrenalgland6
Amygdala6.6
Appendix9.15
AtrioventricularNode7.8
BDCA4+_DentriticCells6.75
Bonemarrow7.05
BronchialEpithelialCells6.35
CD105+_Endothelial8.55
CD14+_Monocytes6.85
CD19+_BCells(neg._sel.)53.25
CD33+_Myeloid7.75
CD34+8.35
CD4+_Tcells6.6
CD56+_NKCells7.35
CD71+_EarlyErythroid6.1
CD8+_Tcells6.6
CardiacMyocytes10.2
Caudatenucleus5.75
Cerebellum5.35
CerebellumPeduncles8.45
CiliaryGanglion6.1
CingulateCortex8
Colorectaladenocarcinoma6.4
DorsalRootGanglion6.1
FetalThyroid7.8
Fetalbrain6.15
Fetalliver5.9
Fetallung5.1
GlobusPallidus5.8
Heart13.45
Hypothalamus7
Kidney6.75
Leukemia_chronicMyelogenousK-5625.85
Leukemia_promyelocytic-HL-609.4
Leukemialymphoblastic(MOLT-4)5.2
Liver9.15
Lung6.95
Lymphnode5.8
Lymphoma_burkitts(Daudi)9.6
Lymphoma_burkitts(Raji)10.7
MedullaOblongata6.75
OccipitalLobe5.75
OlfactoryBulb4.95
Ovary4.55
Pancreas5.3
PancreaticIslet6.95
ParietalLobe7.1
Pituitary9.05
Placenta6.1
Pons6.7
PrefrontalCortex8.05
Prostate7.65
Salivarygland5.7
SkeletalMuscle11.15
Skin6.4
SmoothMuscle7.1
Spinalcord6.85
SubthalamicNucleus6.1
SuperiorCervicalGanglion13.3
TemporalLobe6.9
Testis5.9
TestisGermCell5.2
TestisIntersitial5.3
TestisLeydigCell6.5
TestisSeminiferousTubule5.85
Thalamus6.7
Thymus5.15
Thyroid7.6
Tongue8.55
Tonsil6.7
Trachea5.35
TrigeminalGanglion7.55
Uterus5.1
UterusCorpus6.55
WholeBlood6.9
Wholebrain4.85
colon6.55
pineal_day8.06
pineal_night7.86
retina7.95
small_intestine6.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_299_PI417507815
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.68 ± 0.29
Basal Forebrain6.48 ± 0.33
Basal Part of Pons6.14 ± 0.34
Cerebellar Cortex6.25 ± 0.13
Cerebellar Nuclei6.45 ± 0.3
Claustrum6.57 ± 0.28
Epithalamus6.27 ± 0.45
Frontal Lobe6.55 ± 0.42
Globus Pallidus7.31 ± 0.17
Hypothalamus6.52 ± 0.47
Insula6.54 ± 0.21
Limbic Lobe6.68 ± 0.32
Mesencephalon6.73 ± 0.42
Myelencephalon6.6 ± 0.46
Occipital Lobe6.69 ± 0.3
Parietal Lobe6.62 ± 0.3
Pontine Tegmentum6.75 ± 0.36
Striatum7.6 ± 0.46
Subthalamus6.5 ± 0.32
Temporal Lobe6.44 ± 0.25
Thalamus6.79 ± 0.3
White Matter6.99 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mettl8CBCerebellum3.49
4.67
Mettl8CTXCerebral cortex19.52
14.47
Mettl8HIPHippocampal region14.81
18.53
Mettl8HPFHippocampal formation11.19
12.54
Mettl8HYHypothalamus4.75
3.77
Mettl8LSXLateral septal complex3.96
3.29
Mettl8MBMidbrain2.8
3.74
Mettl8MYMedulla0.84
1.18
Mettl8OLFOlfactory bulb10.45
9.25
Mettl8PPons2
2.56
Mettl8PALPallidum2.55
2.03
Mettl8RHPRetrohippocampal region3.87
3.05
Mettl8sAMYStriatum-like amygdalar nuclei2.44
1.87
Mettl8STRStriatum7.25
4.9
Mettl8STRdStriatum dorsal region9.26
6.35
Mettl8STRvStriatum ventral region5.73
3.34
Mettl8THThalamus13.77
11.24
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved