AutismKB 2.0

Annotation Detail for TMC5


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Basic Information Top
Gene Symbol:TMC5 ( FLJ13593 )
Gene Full Name: transmembrane channel-like 5
Band: 16p12.3
Quick LinksEntrez ID:79838; OMIM: NA; Uniprot ID:TMC5_HUMAN; ENSEMBL ID: ENSG00000103534; HGNC ID: 22999
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult84 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor24 / 119369201
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal39 / 336030711
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue18 / 149255120
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine35 / 234472149
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta6 / 28082521
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach25 / 96619258
testis9 / 33044227
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea29 / 52413553
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219580_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.75
Adipocyte7.15
AdrenalCortex9.65
Adrenalgland6.85
Amygdala7.55
Appendix10.25
AtrioventricularNode7.1
BDCA4+_DentriticCells7.15
Bonemarrow8.9
BronchialEpithelialCells6.85
CD105+_Endothelial6.85
CD14+_Monocytes7.45
CD19+_BCells(neg._sel.)7.3
CD33+_Myeloid8.65
CD34+8.4
CD4+_Tcells7.2
CD56+_NKCells7.85
CD71+_EarlyErythroid7.55
CD8+_Tcells6.55
CardiacMyocytes12.2
Caudatenucleus6.6
Cerebellum6.1
CerebellumPeduncles9.55
CiliaryGanglion6.15
CingulateCortex7.75
Colorectaladenocarcinoma6.95
DorsalRootGanglion6.4
FetalThyroid7.4
Fetalbrain7.05
Fetalliver6.6
Fetallung34.95
GlobusPallidus6.25
Heart11.65
Hypothalamus7.55
Kidney7
Leukemia_chronicMyelogenousK-5626.5
Leukemia_promyelocytic-HL-606.35
Leukemialymphoblastic(MOLT-4)5.6
Liver11.15
Lung14.4
Lymphnode6.3
Lymphoma_burkitts(Daudi)9.95
Lymphoma_burkitts(Raji)11.3
MedullaOblongata6.75
OccipitalLobe6.5
OlfactoryBulb5.75
Ovary5.9
Pancreas6.4
PancreaticIslet9.1
ParietalLobe8.7
Pituitary9
Placenta7.05
Pons7.45
PrefrontalCortex8.3
Prostate12.8
Salivarygland6.2
SkeletalMuscle12.65
Skin6.5
SmoothMuscle7.95
Spinalcord8.05
SubthalamicNucleus7.05
SuperiorCervicalGanglion13.55
TemporalLobe8.75
Testis6.4
TestisGermCell5.8
TestisIntersitial6.65
TestisLeydigCell8.2
TestisSeminiferousTubule6.3
Thalamus7.65
Thymus5.45
Thyroid8.75
Tongue9.3
Tonsil7.35
Trachea79.55
TrigeminalGanglion11.95
Uterus5.75
UterusCorpus7.45
WholeBlood7.95
Wholebrain5.6
colon160.7
pineal_day8.5
pineal_night8.42
retina8.55
small_intestine137.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7032_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.45 ± 0.97
Basal Forebrain1.94 ± 0.27
Basal Part of Pons1.62 ± 0.37
Cerebellar Cortex1.92 ± 0.86
Cerebellar Nuclei2.32 ± 0.73
Claustrum2.79 ± 0.73
Epithalamus1.69 ± 0.81
Frontal Lobe1.85 ± 0.66
Globus Pallidus2.48 ± 0.31
Hypothalamus1.97 ± 0.64
Insula2.21 ± 1.53
Limbic Lobe2.15 ± 0.75
Mesencephalon2.17 ± 0.66
Myelencephalon2.02 ± 0.64
Occipital Lobe2.05 ± 0.6
Parietal Lobe1.93 ± 0.54
Pontine Tegmentum2.06 ± 0.73
Striatum2.09 ± 0.49
Subthalamus2.25 ± 0.75
Temporal Lobe1.91 ± 0.65
Thalamus1.91 ± 0.61
White Matter2.45 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmc5CBCerebellum9.89
16.73
Tmc5CTXCerebral cortex3.97
3
Tmc5HIPHippocampal region3.74
3.65
Tmc5HPFHippocampal formation6.1
5.07
Tmc5HYHypothalamus1.74
1.37
Tmc5LSXLateral septal complex0.03
0
Tmc5MBMidbrain2.07
2.26
Tmc5MYMedulla2.84
3.38
Tmc5OLFOlfactory bulb7.23
5.04
Tmc5PPons2.5
2.73
Tmc5PALPallidum2.84
2.39
Tmc5RHPRetrohippocampal region9.56
6.76
Tmc5sAMYStriatum-like amygdalar nuclei5.8
4.03
Tmc5STRStriatum3.61
2.8
Tmc5STRdStriatum dorsal region3.56
2.97
Tmc5STRvStriatum ventral region4.06
2.61
Tmc5THThalamus4.72
3.51
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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