AutismKB 2.0

Annotation Detail for HDAC11


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Basic Information Top
Gene Symbol:HDAC11 ( FLJ22237,HD11 )
Gene Full Name: histone deacetylase 11
Band: 3p25.1
Quick LinksEntrez ID:79885; OMIM: 607226; Uniprot ID:HDA11_HUMAN; ENSEMBL ID: ENSG00000163517; HGNC ID: 19086
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus19 / 56401233
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor13 / 26384549
glioma15 / 106883140
head and neck tumor10 / 13630273
kidney tumor7 / 68959101
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal213 / 336030763
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain162 / 1100989147
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye8 / 21105437
heart6 / 8962666
intestine2 / 2344728
kidney20 / 21177794
larynx0 / 241450 
liver2 / 2077439
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth7 / 67052104
muscle2 / 10771518
nerve2 / 15768126
ovary3 / 10205129
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate10 / 18934552
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach1 / 9661910
testis34 / 330442102
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord2 / 13680146
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219847_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.15
Adipocyte4.95
AdrenalCortex6.7
Adrenalgland4.35
Amygdala5.4
Appendix6.15
AtrioventricularNode3.95
BDCA4+_DentriticCells4.25
Bonemarrow5.4
BronchialEpithelialCells4.9
CD105+_Endothelial5.05
CD14+_Monocytes4.15
CD19+_BCells(neg._sel.)5.3
CD33+_Myeloid6.25
CD34+6.4
CD4+_Tcells5.4
CD56+_NKCells5.75
CD71+_EarlyErythroid4.65
CD8+_Tcells4.75
CardiacMyocytes6.8
Caudatenucleus4.6
Cerebellum4.05
CerebellumPeduncles5.85
CiliaryGanglion3.4
CingulateCortex6.2
Colorectaladenocarcinoma5.1
DorsalRootGanglion4
FetalThyroid4.9
Fetalbrain5.05
Fetalliver4.45
Fetallung4
GlobusPallidus3.7
Heart6.3
Hypothalamus5.5
Kidney4.25
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-604.45
Leukemialymphoblastic(MOLT-4)4.05
Liver6.95
Lung5.45
Lymphnode4.25
Lymphoma_burkitts(Daudi)6.35
Lymphoma_burkitts(Raji)7.8
MedullaOblongata5.65
OccipitalLobe4.55
OlfactoryBulb3.95
Ovary3.45
Pancreas4.15
PancreaticIslet5.3
ParietalLobe5.8
Pituitary5.9
Placenta5.15
Pons4.85
PrefrontalCortex6.35
Prostate5.75
Salivarygland4.1
SkeletalMuscle6.35
Skin4.05
SmoothMuscle5.75
Spinalcord6.95
SubthalamicNucleus4.5
SuperiorCervicalGanglion5.5
TemporalLobe4.9
Testis7.6
TestisGermCell6.4
TestisIntersitial4.3
TestisLeydigCell5
TestisSeminiferousTubule4.3
Thalamus5.05
Thymus4.05
Thyroid6.35
Tongue4.8
Tonsil4.9
Trachea4.25
TrigeminalGanglion7.65
Uterus3.85
UterusCorpus4.7
WholeBlood5.45
Wholebrain4.45
colon5.05
pineal_day6.34
pineal_night6.08
retina6.125
small_intestine4.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14845_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.35 ± 1.07
Basal Forebrain2 ± 0.28
Basal Part of Pons1.46 ± 0.34
Cerebellar Cortex1.75 ± 0.7
Cerebellar Nuclei2.37 ± 0.7
Claustrum2.48 ± 0.63
Epithalamus1.72 ± 0.77
Frontal Lobe1.93 ± 0.73
Globus Pallidus2.88 ± 0.51
Hypothalamus1.89 ± 0.78
Insula1.88 ± 0.58
Limbic Lobe1.77 ± 0.76
Mesencephalon2.08 ± 0.71
Myelencephalon1.97 ± 0.69
Occipital Lobe1.77 ± 0.74
Parietal Lobe1.8 ± 0.67
Pontine Tegmentum2.07 ± 0.8
Striatum2.07 ± 0.66
Subthalamus2.13 ± 0.75
Temporal Lobe1.91 ± 0.72
Thalamus1.86 ± 0.6
White Matter3.48 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hdac11CBCerebellum59.62
100
Hdac11CTXCerebral cortex100
100
Hdac11HIPHippocampal region100
100
Hdac11HPFHippocampal formation100
100
Hdac11HYHypothalamus100
100
Hdac11LSXLateral septal complex100
100
Hdac11MBMidbrain100
100
Hdac11MYMedulla100
100
Hdac11OLFOlfactory bulb100
100
Hdac11PPons100
100
Hdac11PALPallidum100
100
Hdac11RHPRetrohippocampal region100
100
Hdac11sAMYStriatum-like amygdalar nuclei100
100
Hdac11STRStriatum100
100
Hdac11STRdStriatum dorsal region100
100
Hdac11STRvStriatum ventral region100
100
Hdac11THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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