AutismKB 2.0

Annotation Detail for THNSL1


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Basic Information Top
Gene Symbol:THNSL1 ( FLJ22002,TSH1 )
Gene Full Name: threonine synthase-like 1 (S. cerevisiae)
Band: 10p12.1
Quick LinksEntrez ID:79896; OMIM: 611260; Uniprot ID:THNS1_HUMAN; ENSEMBL ID: ENSG00000185875; HGNC ID: 26160
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal52 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain22 / 110098919
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye4 / 21105418
heart0 / 896260 
intestine1 / 2344724
kidney5 / 21177723
larynx0 / 241450 
liver2 / 2077439
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach0 / 966190 
testis13 / 33044239
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219800_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.4
Adipocyte7.4
AdrenalCortex11.05
Adrenalgland7.25
Amygdala7.55
Appendix12.7
AtrioventricularNode10.4
BDCA4+_DentriticCells7.15
Bonemarrow9.6
BronchialEpithelialCells7.1
CD105+_Endothelial7.5
CD14+_Monocytes8.4
CD19+_BCells(neg._sel.)8
CD33+_Myeloid8.9
CD34+9.45
CD4+_Tcells7.35
CD56+_NKCells8.35
CD71+_EarlyErythroid7.7
CD8+_Tcells6.4
CardiacMyocytes18.55
Caudatenucleus6.95
Cerebellum6.4
CerebellumPeduncles10.3
CiliaryGanglion9.35
CingulateCortex8.4
Colorectaladenocarcinoma7.65
DorsalRootGanglion11.6
FetalThyroid7.95
Fetalbrain7.15
Fetalliver6.9
Fetallung5.4
GlobusPallidus9.6
Heart18.55
Hypothalamus7.9
Kidney7.9
Leukemia_chronicMyelogenousK-5626.8
Leukemia_promyelocytic-HL-606.8
Leukemialymphoblastic(MOLT-4)5.8
Liver14.1
Lung8.35
Lymphnode6.15
Lymphoma_burkitts(Daudi)10.7
Lymphoma_burkitts(Raji)13.1
MedullaOblongata6.65
OccipitalLobe6.9
OlfactoryBulb5.85
Ovary7.05
Pancreas7.15
PancreaticIslet8.55
ParietalLobe9.5
Pituitary9.15
Placenta7.25
Pons8.1
PrefrontalCortex9
Prostate8.45
Salivarygland6.85
SkeletalMuscle13.45
Skin9.5
SmoothMuscle8.65
Spinalcord8.05
SubthalamicNucleus8.1
SuperiorCervicalGanglion16.35
TemporalLobe7.45
Testis6.45
TestisGermCell5.8
TestisIntersitial6.7
TestisLeydigCell8.65
TestisSeminiferousTubule6.65
Thalamus8.25
Thymus5.65
Thyroid8.95
Tongue9.9
Tonsil7.8
Trachea6.2
TrigeminalGanglion12.2
Uterus5.75
UterusCorpus8.95
WholeBlood8
Wholebrain5.85
colon7.5
pineal_day9.14
pineal_night9.2
retina9.275
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P127002
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.13 ± 0.45
Basal Forebrain5.79 ± 0.2
Basal Part of Pons5.66 ± 0.46
Cerebellar Cortex5.54 ± 0.31
Cerebellar Nuclei5.62 ± 0.2
Claustrum6.11 ± 0.47
Epithalamus5.58 ± 0.39
Frontal Lobe5.57 ± 0.36
Globus Pallidus5.41 ± 0.22
Hypothalamus5.8 ± 0.54
Insula5.69 ± 0.31
Limbic Lobe5.85 ± 0.4
Mesencephalon5.73 ± 0.43
Myelencephalon5.71 ± 0.38
Occipital Lobe5.96 ± 0.33
Parietal Lobe5.74 ± 0.38
Pontine Tegmentum5.72 ± 0.41
Striatum6.03 ± 0.38
Subthalamus5.71 ± 0.2
Temporal Lobe5.78 ± 0.35
Thalamus5.53 ± 0.33
White Matter5.45 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Thnsl1CBCerebellum2.56
3.3
Thnsl1CTXCerebral cortex4.34
3.25
Thnsl1HIPHippocampal region1.64
1.79
Thnsl1HPFHippocampal formation1.32
1.25
Thnsl1HYHypothalamus0.6
0.52
Thnsl1LSXLateral septal complex0.42
0.54
Thnsl1MBMidbrain2.23
2.33
Thnsl1MYMedulla5.82
7.13
Thnsl1OLFOlfactory bulb4.03
3.72
Thnsl1PPons3.04
3.66
Thnsl1PALPallidum0.78
0.69
Thnsl1RHPRetrohippocampal region0.87
0.61
Thnsl1sAMYStriatum-like amygdalar nuclei1.18
1.06
Thnsl1STRStriatum1.71
1.38
Thnsl1STRdStriatum dorsal region1.9
1.6
Thnsl1STRvStriatum ventral region1.86
1.16
Thnsl1THThalamus3.29
3.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00007614 14 657 670 TCPVIISSTAHYSK Peptide Atlas
THNS1_HUMAN_57 12 57 68 NIILMGPPGAGK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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