Annotation Detail for DOK3
Basic Information Top
| Gene Symbol: | DOK3 ( DOKL,FLJ22570,FLJ39939 ) |
|---|---|
| Gene Full Name: | docking protein 3 |
| Band: | 5q35.3 |
| Quick Links | Entrez ID:79930; OMIM: 611435; Uniprot ID:DOK3_HUMAN; ENSEMBL ID: ENSG00000146094; HGNC ID: 24583 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.720849
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 3 / 564012 | 5 |  |
| neonate | 4 / 31097 | 128 |  |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 52 / 1939121 | 26 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 1 / 94178 | 10 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 1 / 114246 | 8 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 | |
| germ cell tumor | 14 / 263845 | 53 | |
| glioma | 3 / 106883 | 28 | |
| head and neck tumor | 1 / 136302 | 7 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 21 / 95842 | 219 |  |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 2 / 103127 | 19 | |
| lymphoma | 19 / 71755 | 264 | |
| non-neoplasia | 5 / 97250 | 51 | |
| normal | 102 / 3360307 | 30 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 36 / 123478 | 291 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 3 / 48801 | 61 | |
| brain | 17 / 1100989 | 15 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 5 / 149255 | 33 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 1 / 211054 | 4 | |
| heart | 3 / 89626 | 33 | |
| intestine | 3 / 234472 | 12 | |
| kidney | 2 / 211777 | 9 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 7 / 336974 | 20 | |
| lymph | 9 / 44270 | 203 | |
| lymph node | 15 / 91610 | 163 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 3 / 280825 | 10 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 25 / 53952 | 463 | |
| stomach | 1 / 96619 | 10 | |
| testis | 6 / 330442 | 18 | |
| thymus | 10 / 81131 | 123 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 13 / 16999 | 764 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 6 / 232878 | 25 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 220320_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 4.5 | |
| Adipocyte | 3.5 | |
| AdrenalCortex | 3.75 | |
| Adrenalgland | 2.95 | |
| Amygdala | 3.75 | |
| Appendix | 3.55 | |
| AtrioventricularNode | 2.65 | |
| BDCA4+_DentriticCells | 4 | |
| Bonemarrow | 3.65 | |
| BronchialEpithelialCells | 3.5 | |
| CD105+_Endothelial | 3.6 | |
| CD14+_Monocytes | 4.05 | |
| CD19+_BCells(neg._sel.) | 3.8 | |
| CD33+_Myeloid | 4.6 | |
| CD34+ | 4.55 | |
| CD4+_Tcells | 3.85 | |
| CD56+_NKCells | 4.25 | |
| CD71+_EarlyErythroid | 3.35 | |
| CD8+_Tcells | 3.4 | |
| CardiacMyocytes | 4.5 | |
| Caudatenucleus | 3.15 | |
| Cerebellum | 2.9 | |
| CerebellumPeduncles | 4.1 | |
| CiliaryGanglion | 2.45 | |
| CingulateCortex | 3.6 | |
| Colorectaladenocarcinoma | 3.55 | |
| DorsalRootGanglion | 2.65 | |
| FetalThyroid | 3.75 | |
| Fetalbrain | 3.55 | |
| Fetalliver | 3.05 | |
| Fetallung | 3 | |
| GlobusPallidus | 2.6 | |
| Heart | 4.5 | |
| Hypothalamus | 3.95 | |
| Kidney | 2.8 | |
| Leukemia_chronicMyelogenousK-562 | 3.2 | |
| Leukemia_promyelocytic-HL-60 | 3.3 | |
| Leukemialymphoblastic(MOLT-4) | 2.9 | |
| Liver | 4.65 | |
| Lung | 3.95 | |
| Lymphnode | 3.35 | |
| Lymphoma_burkitts(Daudi) | 4.5 | |
| Lymphoma_burkitts(Raji) | 4.95 | |
| MedullaOblongata | 3.25 | |
| OccipitalLobe | 3.2 | |
| OlfactoryBulb | 2.75 | |
| Ovary | 2.35 | |
| Pancreas | 3.2 | |
| PancreaticIslet | 3.8 | |
| ParietalLobe | 3.75 | |
| Pituitary | 4.1 | |
| Placenta | 3.65 | |
| Pons | 3.35 | |
| PrefrontalCortex | 4.45 | |
| Prostate | 4.2 | |
| Salivarygland | 2.8 | |
| SkeletalMuscle | 4.2 | |
| Skin | 2.65 | |
| SmoothMuscle | 4.05 | |
| Spinalcord | 3.8 | |
| SubthalamicNucleus | 3.2 | |
| SuperiorCervicalGanglion | 3.9 | |
| TemporalLobe | 3.2 | |
| Testis | 3 | |
| TestisGermCell | 3 | |
| TestisIntersitial | 2.95 | |
| TestisLeydigCell | 3.5 | |
| TestisSeminiferousTubule | 3.05 | |
| Thalamus | 3.55 | |
| Thymus | 2.8 | |
| Thyroid | 4.4 | |
| Tongue | 3.45 | |
| Tonsil | 3.45 | |
| Trachea | 3 | |
| TrigeminalGanglion | 3.45 | |
| Uterus | 2.9 | |
| UterusCorpus | 3.2 | |
| WholeBlood | 4 | |
| Wholebrain | 3 | |
| colon | 3.55 | |
| pineal_day | 4.38 | |
| pineal_night | 4.3 | |
| retina | 4.3 | |
| small_intestine | 3.4 | |
- Probe name: A_23_P133506
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.22 ± 0.52 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 3.79 ± 0.45 | |
| Basal Part of Pons | 4.45 ± 0.28 | |
| Cerebellar Cortex | 3.93 ± 0.57 | |
| Cerebellar Nuclei | 4.2 ± 0.62 | |
| Claustrum | 3.98 ± 0.71 | |
| Epithalamus | 3.57 ± 0.5 | |
| Frontal Lobe | 4 ± 0.58 | |
| Globus Pallidus | 4.39 ± 0.42 | |
| Hypothalamus | 3.68 ± 0.5 | |
| Insula | 3.89 ± 0.28 | |
| Limbic Lobe | 4.11 ± 0.53 | |
| Mesencephalon | 4.01 ± 0.62 | |
| Myelencephalon | 4 ± 0.56 | |
| Occipital Lobe | 4.2 ± 0.61 | |
| Parietal Lobe | 4.09 ± 0.47 | |
| Pontine Tegmentum | 3.85 ± 0.59 | |
| Striatum | 3.9 ± 0.49 | |
| Subthalamus | 3.57 ± 0.92 | |
| Temporal Lobe | 3.92 ± 0.55 | |
| Thalamus | 3.95 ± 0.51 | |
| White Matter | 3.52 ± 0.38 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Dok3 | CB | Cerebellum | 9.16 | |
| 12.33 | | |||
| Dok3 | CTX | Cerebral cortex | 19.61 | |
| 7.73 | | |||
| Dok3 | HIP | Hippocampal region | 13.71 | |
| 10.92 | | |||
| Dok3 | HPF | Hippocampal formation | 15.38 | |
| 9.14 | | |||
| Dok3 | HY | Hypothalamus | 3.72 | |
| 1.78 | | |||
| Dok3 | LSX | Lateral septal complex | 0.96 | |
| 0.2 | | |||
| Dok3 | MB | Midbrain | 4.78 | |
| 2.98 | | |||
| Dok3 | MY | Medulla | 14.79 | |
| 11.48 | | |||
| Dok3 | OLF | Olfactory bulb | 19.03 | |
| 9.31 | | |||
| Dok3 | P | Pons | 9.51 | |
| 7.82 | | |||
| Dok3 | PAL | Pallidum | 3.03 | |
| 1.24 | | |||
| Dok3 | RHP | Retrohippocampal region | 17.96 | |
| 7.47 | | |||
| Dok3 | sAMY | Striatum-like amygdalar nuclei | 0.87 | |
| 0.38 | | |||
| Dok3 | STR | Striatum | 3.95 | |
| 1.62 | | |||
| Dok3 | STRd | Striatum dorsal region | 3.44 | |
| 1.36 | | |||
| Dok3 | STRv | Striatum ventral region | 7.89 | |
| 3.29 | | |||
| Dok3 | TH | Thalamus | 7 | |
| 3.23 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| DOK3_HUMAN_299 | 11 | 299 | 309 | LCRAVAGAIAR | PRIDE |
| PAp00035514 | 17 | 74 | 90 | LADCVSVLPADGESCPR | Peptide Atlas |