AutismKB 2.0

Annotation Detail for DENND2D


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Basic Information Top
Gene Symbol:DENND2D ( FLJ22457,RP5-1180E21.2 )
Gene Full Name: DENN/MADD domain containing 2D
Band: 1p13.3-p13.2
Quick LinksEntrez ID:79961; OMIM: NA; Uniprot ID:DEN2D_HUMAN; ENSEMBL ID: ENSG00000162777; HGNC ID: 26192
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult75 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor19 / 26384572
glioma0 / 1068830 
head and neck tumor6 / 13630244
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma8 / 71755111
non-neoplasia6 / 9725061
normal109 / 336030732
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor14 / 124949112
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites9 / 40015224
bladder3 / 29757100
blood9 / 12347872
bone0 / 716550 
bone marrow1 / 4880120
brain3 / 11009892
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine10 / 23447242
kidney6 / 21177728
larynx0 / 241450 
liver7 / 20774333
lung7 / 33697420
lymph5 / 44270112
lymph node5 / 9161054
mammary gland9 / 15327158
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary2 / 10205119
pancreas2 / 2148129
parathyroid4 / 20539194
pharynx5 / 41328120
pituitary gland1 / 1658560
placenta19 / 28082567
prostate3 / 18934515
salivary gland1 / 2015549
skin14 / 21057466
spleen20 / 53952370
stomach5 / 9661951
testis14 / 33044242
thymus23 / 81131283
thyroid3 / 4747363
tonsil2 / 16999117
trachea4 / 5241376
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221081_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts934.55
Adipocyte5.1
AdrenalCortex9.45
Adrenalgland5.85
Amygdala5.15
Appendix5.55
AtrioventricularNode4.55
BDCA4+_DentriticCells55.3
Bonemarrow6.55
BronchialEpithelialCells5.3
CD105+_Endothelial6
CD14+_Monocytes14.05
CD19+_BCells(neg._sel.)184.1
CD33+_Myeloid12.2
CD34+14.7
CD4+_Tcells1512.1
CD56+_NKCells1211.3
CD71+_EarlyErythroid4.75
CD8+_Tcells1356.35
CardiacMyocytes6.7
Caudatenucleus4.6
Cerebellum4.25
CerebellumPeduncles6
CiliaryGanglion3.8
CingulateCortex5.4
Colorectaladenocarcinoma5.75
DorsalRootGanglion4.1
FetalThyroid6.15
Fetalbrain5.2
Fetalliver4.65
Fetallung5.3
GlobusPallidus3.95
Heart6.75
Hypothalamus5.45
Kidney4.55
Leukemia_chronicMyelogenousK-5624.75
Leukemia_promyelocytic-HL-604.5
Leukemialymphoblastic(MOLT-4)184.25
Liver7.6
Lung62.7
Lymphnode365.9
Lymphoma_burkitts(Daudi)33.25
Lymphoma_burkitts(Raji)8
MedullaOblongata4.85
OccipitalLobe4.7
OlfactoryBulb4.2
Ovary3.5
Pancreas8.05
PancreaticIslet15.65
ParietalLobe5.55
Pituitary9.1
Placenta47.6
Pons5.05
PrefrontalCortex6.2
Prostate10.4
Salivarygland24.45
SkeletalMuscle6.15
Skin4.3
SmoothMuscle6.1
Spinalcord5.6
SubthalamicNucleus4.85
SuperiorCervicalGanglion6.35
TemporalLobe4.8
Testis10.55
TestisGermCell4.45
TestisIntersitial4.5
TestisLeydigCell6.2
TestisSeminiferousTubule5.6
Thalamus5.35
Thymus167.7
Thyroid9.8
Tongue8.1
Tonsil215.05
Trachea7.85
TrigeminalGanglion5.4
Uterus4.4
UterusCorpus5
WholeBlood191.45
Wholebrain4.2
colon6.6
pineal_day6.18
pineal_night6.14
retina6.15
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9250_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.42 ± 1
Basal Forebrain2.23 ± 0.41
Basal Part of Pons2.08 ± 0.58
Cerebellar Cortex2.78 ± 0.73
Cerebellar Nuclei3.18 ± 0.78
Claustrum2.8 ± 0.61
Epithalamus3.22 ± 0.5
Frontal Lobe2.54 ± 0.91
Globus Pallidus3.69 ± 0.45
Hypothalamus2.28 ± 0.93
Insula2.01 ± 0.88
Limbic Lobe1.99 ± 0.77
Mesencephalon2.19 ± 0.71
Myelencephalon2.5 ± 0.81
Occipital Lobe2.25 ± 0.84
Parietal Lobe2.79 ± 0.88
Pontine Tegmentum2.75 ± 0.99
Striatum1.87 ± 0.75
Subthalamus1.76 ± 0.67
Temporal Lobe2.18 ± 0.88
Thalamus3.37 ± 0.96
White Matter3.19 ± 0.89
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dennd2dSTRdStriatum dorsal region0.04
0.03
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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