AutismKB 2.0

Annotation Detail for DOCK5


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Basic Information Top
Gene Symbol:DOCK5 ( DKFZp451J181,DKFZp779M164,DKFZp781J211 )
Gene Full Name: dedicator of cytokinesis 5
Band: 8p21.2
Quick LinksEntrez ID:80005; OMIM: NA; Uniprot ID:DOCK5_HUMAN; ENSEMBL ID: ENSG00000147459; HGNC ID: 23476
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult64 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor5 / 9635951
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal64 / 336030719
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone2 / 7165527
bone marrow1 / 4880120
brain21 / 110098919
cervix3 / 4817162
connective tissue1 / 1492556
ear2 / 16212123
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine7 / 23447229
kidney1 / 2117774
larynx0 / 241450 
liver9 / 20774343
lung27 / 33697480
lymph0 / 442700 
lymph node1 / 9161010
mammary gland3 / 15327119
mouth3 / 6705244
muscle4 / 10771537
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate8 / 18934542
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219921_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4
Adipocyte3.15
AdrenalCortex3.25
Adrenalgland2.65
Amygdala3.4
Appendix3.2
AtrioventricularNode2.4
BDCA4+_DentriticCells3.55
Bonemarrow3.1
BronchialEpithelialCells3.15
CD105+_Endothelial3.25
CD14+_Monocytes3.4
CD19+_BCells(neg._sel.)3.4
CD33+_Myeloid4.1
CD34+4.05
CD4+_Tcells3.5
CD56+_NKCells3.85
CD71+_EarlyErythroid2.95
CD8+_Tcells3.1
CardiacMyocytes4.05
Caudatenucleus2.85
Cerebellum2.55
CerebellumPeduncles3.6
CiliaryGanglion2.25
CingulateCortex3.25
Colorectaladenocarcinoma3.15
DorsalRootGanglion2.4
FetalThyroid3.1
Fetalbrain3.15
Fetalliver2.7
Fetallung2.65
GlobusPallidus2.3
Heart4
Hypothalamus3.45
Kidney2.55
Leukemia_chronicMyelogenousK-5622.85
Leukemia_promyelocytic-HL-602.8
Leukemialymphoblastic(MOLT-4)2.55
Liver4.15
Lung3.5
Lymphnode2.7
Lymphoma_burkitts(Daudi)4.05
Lymphoma_burkitts(Raji)4.4
MedullaOblongata2.9
OccipitalLobe2.85
OlfactoryBulb2.5
Ovary2.1
Pancreas2.55
PancreaticIslet3.4
ParietalLobe3.35
Pituitary3.7
Placenta3.35
Pons3
PrefrontalCortex4
Prostate3.7
Salivarygland2.5
SkeletalMuscle3.6
Skin2.45
SmoothMuscle3.6
Spinalcord3.4
SubthalamicNucleus2.9
SuperiorCervicalGanglion3.55
TemporalLobe2.9
Testis2.7
TestisGermCell2.7
TestisIntersitial2.65
TestisLeydigCell3.15
TestisSeminiferousTubule2.75
Thalamus3.2
Thymus2.55
Thyroid4
Tongue3.05
Tonsil3.05
Trachea2.65
TrigeminalGanglion3.15
Uterus2.65
UterusCorpus2.85
WholeBlood3.6
Wholebrain2.7
colon3.2
pineal_day3.96
pineal_night3.9
retina3.85
small_intestine3.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P350245
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.17 ± 0.84
Basal Forebrain6.45 ± 0.59
Basal Part of Pons5.91 ± 0.67
Cerebellar Cortex5.07 ± 0.38
Cerebellar Nuclei7.12 ± 0.59
Claustrum5.04 ± 0.94
Epithalamus6.25 ± 0.41
Frontal Lobe5.49 ± 1.01
Globus Pallidus7.63 ± 0.41
Hypothalamus4.94 ± 0.92
Insula5.04 ± 0.71
Limbic Lobe5.02 ± 0.85
Mesencephalon5.74 ± 0.84
Myelencephalon5.72 ± 0.83
Occipital Lobe5.68 ± 0.79
Parietal Lobe5.55 ± 0.91
Pontine Tegmentum5.84 ± 0.8
Striatum6.5 ± 0.8
Subthalamus6.35 ± 0.25
Temporal Lobe5.35 ± 0.83
Thalamus6.22 ± 0.58
White Matter8.97 ± 0.46
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DOCK5_HUMAN_526 14 526 539 LIALQMPLLTEGIR PRIDE
PAp00038294 24 1800 1823 TLSSPSLQTDGIAATPVPPPPPPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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