AutismKB 2.0

Annotation Detail for PHC3


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Basic Information Top
Gene Symbol:PHC3 ( DKFZp313K1221,EDR3,FLJ12729,FLJ12967,HPH3,MGC88144 )
Gene Full Name: polyhomeotic homolog 3 (Drosophila)
Band: 3q26.2
Quick LinksEntrez ID:80012; OMIM: NA; Uniprot ID:PHC3_HUMAN; ENSEMBL ID: ENSG00000173889; HGNC ID: 15682
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult100 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor6 / 11424652
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor10 / 26384537
glioma5 / 10688346
head and neck tumor18 / 136302132
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal111 / 336030733
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood4 / 12347832
bone6 / 7165583
bone marrow0 / 488010 
brain25 / 110098922
cervix4 / 4817183
connective tissue2 / 14925513
ear4 / 16212246
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye7 / 21105433
heart0 / 896260 
intestine9 / 23447238
kidney11 / 21177751
larynx2 / 2414582
liver7 / 20774333
lung6 / 33697417
lymph2 / 4427045
lymph node9 / 9161098
mammary gland15 / 15327197
mouth9 / 67052134
muscle6 / 10771555
nerve0 / 157680 
ovary2 / 10205119
pancreas1 / 2148124
parathyroid3 / 20539146
pharynx8 / 41328193
pituitary gland1 / 1658560
placenta8 / 28082528
prostate7 / 18934536
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach1 / 9661910
testis20 / 33044260
thymus6 / 8113173
thyroid6 / 47473126
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P179590
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.05 ± 1.01
Basal Forebrain1.62 ± 0.2
Basal Part of Pons1.33 ± 0.37
Cerebellar Cortex1.48 ± 0.7
Cerebellar Nuclei1.95 ± 0.7
Claustrum2.49 ± 0.83
Epithalamus1.31 ± 0.7
Frontal Lobe1.49 ± 0.63
Globus Pallidus2.22 ± 0.31
Hypothalamus1.71 ± 0.64
Insula1.54 ± 0.57
Limbic Lobe1.62 ± 0.63
Mesencephalon1.77 ± 0.68
Myelencephalon1.67 ± 0.66
Occipital Lobe1.68 ± 0.72
Parietal Lobe1.58 ± 0.62
Pontine Tegmentum1.67 ± 0.63
Striatum1.83 ± 0.65
Subthalamus1.77 ± 0.62
Temporal Lobe1.51 ± 0.59
Thalamus1.6 ± 0.57
White Matter2.14 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Phc3CBCerebellum70.65
100
Phc3CTXCerebral cortex100
100
Phc3HIPHippocampal region85.28
100
Phc3HPFHippocampal formation97.38
100
Phc3HYHypothalamus90.64
78.16
Phc3LSXLateral septal complex100
100
Phc3MBMidbrain87.67
82.03
Phc3MYMedulla78.81
81.37
Phc3OLFOlfactory bulb100
100
Phc3PPons71.61
71.75
Phc3PALPallidum83.04
77.65
Phc3RHPRetrohippocampal region100
100
Phc3sAMYStriatum-like amygdalar nuclei92.94
74.87
Phc3STRStriatum100
89.03
Phc3STRdStriatum dorsal region100
88.25
Phc3STRvStriatum ventral region100
94.38
Phc3THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00041305 24 733 756 KRPLLDNQVINSVCVQPELQNNTK Peptide Atlas
PHC3_HUMAN_606 19 606 624 MDRTPPPPTLSPAAITVGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018