AutismKB 2.0

Annotation Detail for WWC2


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Basic Information Top
Gene Symbol:WWC2 ( BOMB,FLJ22029,FLJ34082 )
Gene Full Name: WW and C2 domain containing 2
Band: 4q35.1
Quick LinksEntrez ID:80014; OMIM: NA; Uniprot ID:WWC2_HUMAN; ENSEMBL ID: ENSG00000151718; HGNC ID: 24148
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst8 / 62319128
fetus22 / 56401239
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult42 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor11 / 26384541
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor6 / 9635962
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal92 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain16 / 110098914
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine7 / 23447229
kidney8 / 21177737
larynx0 / 241450 
liver13 / 20774362
lung15 / 33697444
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate6 / 18934531
salivary gland1 / 2015549
skin8 / 21057437
spleen0 / 539520 
stomach1 / 9661910
testis8 / 33044224
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218775_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.3
Adipocyte22.15
AdrenalCortex32.1
Adrenalgland21.95
Amygdala21.3
Appendix28.35
AtrioventricularNode28.85
BDCA4+_DentriticCells14.4
Bonemarrow24.75
BronchialEpithelialCells20.95
CD105+_Endothelial20.75
CD14+_Monocytes23.85
CD19+_BCells(neg._sel.)20.8
CD33+_Myeloid26.1
CD34+23.75
CD4+_Tcells19.15
CD56+_NKCells23.7
CD71+_EarlyErythroid20.7
CD8+_Tcells13.8
CardiacMyocytes28.85
Caudatenucleus19.95
Cerebellum18.05
CerebellumPeduncles30.3
CiliaryGanglion29.9
CingulateCortex24.05
Colorectaladenocarcinoma25.1
DorsalRootGanglion33.4
FetalThyroid34.7
Fetalbrain24.7
Fetalliver22.05
Fetallung37.15
GlobusPallidus22.25
Heart29.8
Hypothalamus22.3
Kidney24.55
Leukemia_chronicMyelogenousK-56220.05
Leukemia_promyelocytic-HL-6018.45
Leukemialymphoblastic(MOLT-4)16.9
Liver35.2
Lung42.05
Lymphnode19
Lymphoma_burkitts(Daudi)28.1
Lymphoma_burkitts(Raji)32.5
MedullaOblongata22.7
OccipitalLobe19.75
OlfactoryBulb29.4
Ovary20.45
Pancreas21.35
PancreaticIslet23.95
ParietalLobe27.85
Pituitary26.15
Placenta21.05
Pons23.75
PrefrontalCortex31.45
Prostate29.7
Salivarygland23.75
SkeletalMuscle30.55
Skin35.7
SmoothMuscle25
Spinalcord28.35
SubthalamicNucleus22.05
SuperiorCervicalGanglion62.6
TemporalLobe29.35
Testis20.05
TestisGermCell26.05
TestisIntersitial35.65
TestisLeydigCell26.5
TestisSeminiferousTubule25.2
Thalamus24.85
Thymus12.8
Thyroid79.95
Tongue42.45
Tonsil22.05
Trachea18.5
TrigeminalGanglion38.1
Uterus43.65
UterusCorpus23.3
WholeBlood21.15
Wholebrain17.1
colon20.7
pineal_day26.58
pineal_night25.44
retina23.4
small_intestine20.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P92569
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.97 ± 0.25
Basal Forebrain7.03 ± 0.28
Basal Part of Pons6.93 ± 0.41
Cerebellar Cortex6.81 ± 0.28
Cerebellar Nuclei7.43 ± 0.3
Claustrum6.56 ± 0.45
Epithalamus7.86 ± 0.54
Frontal Lobe7 ± 0.31
Globus Pallidus7.71 ± 0.2
Hypothalamus6.92 ± 0.78
Insula7.17 ± 0.23
Limbic Lobe7.12 ± 0.32
Mesencephalon7.15 ± 0.33
Myelencephalon7.08 ± 0.4
Occipital Lobe7.51 ± 0.32
Parietal Lobe7.02 ± 0.32
Pontine Tegmentum7.08 ± 0.44
Striatum7.34 ± 0.27
Subthalamus7.25 ± 0.38
Temporal Lobe7.03 ± 0.29
Thalamus6.9 ± 0.26
White Matter8.38 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wwc2CBCerebellum60
100
Wwc2CTXCerebral cortex100
100
Wwc2HIPHippocampal region65.81
96.4
Wwc2HPFHippocampal formation76.87
96.94
Wwc2HYHypothalamus47.79
39.37
Wwc2LSXLateral septal complex79.5
67.6
Wwc2MBMidbrain54.1
52.51
Wwc2MYMedulla72.81
86.28
Wwc2OLFOlfactory bulb91.18
92.47
Wwc2PPons53.08
57.07
Wwc2PALPallidum67.98
67.46
Wwc2RHPRetrohippocampal region97.8
100
Wwc2sAMYStriatum-like amygdalar nuclei73.89
60.2
Wwc2STRStriatum82.82
68.24
Wwc2STRdStriatum dorsal region83.08
68.09
Wwc2STRvStriatum ventral region92.47
76.23
Wwc2THThalamus64.74
59.38
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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