AutismKB 2.0

Annotation Detail for FBXL18


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Basic Information Top
Gene Symbol:FBXL18 ( FLJ10776,FLJ11467,FLJ26934,FLJ38075,FLJ41541,Fbl18 )
Gene Full Name: F-box and leucine-rich repeat protein 18
Band: 7p22.1
Quick LinksEntrez ID:80028; OMIM: 609084; Uniprot ID:FXL18_HUMAN; ENSEMBL ID: ENSG00000155034; HGNC ID: 21874
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult35 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor7 / 10312767
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal53 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor10 / 12494980
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain29 / 110098926
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye9 / 21105442
heart1 / 8962611
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver3 / 20774314
lung10 / 33697429
lymph1 / 4427022
lymph node2 / 9161021
mammary gland3 / 15327119
mouth4 / 6705259
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate5 / 18934526
salivary gland0 / 201550 
skin14 / 21057466
spleen1 / 5395218
stomach0 / 966190 
testis5 / 33044215
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215068_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.4
Adipocyte17.45
AdrenalCortex9.55
Adrenalgland8
Amygdala24.7
Appendix9.95
AtrioventricularNode10.5
BDCA4+_DentriticCells9.9
Bonemarrow9.35
BronchialEpithelialCells9.3
CD105+_Endothelial9.5
CD14+_Monocytes8.75
CD19+_BCells(neg._sel.)9.6
CD33+_Myeloid10.05
CD34+10.65
CD4+_Tcells8.25
CD56+_NKCells10
CD71+_EarlyErythroid8.75
CD8+_Tcells7.25
CardiacMyocytes13.1
Caudatenucleus11.65
Cerebellum15.35
CerebellumPeduncles14.5
CiliaryGanglion7.2
CingulateCortex10.95
Colorectaladenocarcinoma9.4
DorsalRootGanglion7.35
FetalThyroid9.15
Fetalbrain10.35
Fetalliver8.1
Fetallung7.1
GlobusPallidus8.85
Heart18.5
Hypothalamus9.85
Kidney11.65
Leukemia_chronicMyelogenousK-5628.55
Leukemia_promyelocytic-HL-607.7
Leukemialymphoblastic(MOLT-4)7.05
Liver12.6
Lung10.4
Lymphnode6.9
Lymphoma_burkitts(Daudi)12.65
Lymphoma_burkitts(Raji)13.35
MedullaOblongata19.95
OccipitalLobe9.7
OlfactoryBulb6.55
Ovary6.2
Pancreas7.05
PancreaticIslet9.45
ParietalLobe10.1
Pituitary10.9
Placenta9.75
Pons8.95
PrefrontalCortex22.25
Prostate11.1
Salivarygland6.95
SkeletalMuscle20.15
Skin7.25
SmoothMuscle10.7
Spinalcord9.8
SubthalamicNucleus8.6
SuperiorCervicalGanglion13.15
TemporalLobe14.3
Testis8.35
TestisGermCell7.55
TestisIntersitial7.9
TestisLeydigCell9.6
TestisSeminiferousTubule7.75
Thalamus9.6
Thymus9.25
Thyroid11.4
Tongue9.3
Tonsil9.15
Trachea7.9
TrigeminalGanglion9.45
Uterus7.15
UterusCorpus8.35
WholeBlood10.2
Wholebrain21.4
colon9.5
pineal_day11.08
pineal_night11.46
retina11.2
small_intestine9.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P423957
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.34 ± 1.08
Basal Forebrain3.21 ± 0.4
Basal Part of Pons3.55 ± 0.51
Cerebellar Cortex3.96 ± 0.61
Cerebellar Nuclei3.51 ± 0.3
Claustrum4.22 ± 0.65
Epithalamus3.22 ± 0.54
Frontal Lobe3.66 ± 0.62
Globus Pallidus3.45 ± 0.47
Hypothalamus3.3 ± 0.59
Insula3.26 ± 0.8
Limbic Lobe3.88 ± 0.66
Mesencephalon3.72 ± 0.67
Myelencephalon3.7 ± 0.66
Occipital Lobe3.74 ± 0.76
Parietal Lobe3.7 ± 0.7
Pontine Tegmentum3.62 ± 0.62
Striatum3.54 ± 0.7
Subthalamus3.82 ± 0.22
Temporal Lobe3.67 ± 0.69
Thalamus3.43 ± 0.64
White Matter3.63 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fbxl18CBCerebellum3.9
4.93
Fbxl18CTXCerebral cortex1.95
1.61
Fbxl18HIPHippocampal region4.78
4.49
Fbxl18HPFHippocampal formation4.29
3.82
Fbxl18HYHypothalamus0.21
0.15
Fbxl18LSXLateral septal complex2.1
1.43
Fbxl18MBMidbrain0.68
0.79
Fbxl18MYMedulla1.37
1.55
Fbxl18OLFOlfactory bulb1.45
1.07
Fbxl18PPons1.74
2.18
Fbxl18PALPallidum1.2
1.02
Fbxl18RHPRetrohippocampal region3.66
3.04
Fbxl18sAMYStriatum-like amygdalar nuclei0.29
0.21
Fbxl18STRStriatum0.62
0.53
Fbxl18STRdStriatum dorsal region0.55
0.54
Fbxl18STRvStriatum ventral region0.52
0.38
Fbxl18THThalamus0.44
0.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FXL18_HUMAN_435 12 435 446 APAQPAMHAVPR PRIDE
FXL18_HUMAN_561 24 561 584 SLSLANLGMMGKVVYMPALSDMLK PRIDE
PAp00132841 26 667 692 SFQAERPALNVVIFPLLHEGLTDVIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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