AutismKB 2.0

Annotation Detail for EDC3


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Basic Information Top
Gene Symbol:EDC3 ( FLJ21128,FLJ31777,LSM16,YJDC,YJEFN2 )
Gene Full Name: enhancer of mRNA decapping 3 homolog (S. cerevisiae)
Band: 15q24.1
Quick LinksEntrez ID:80153; OMIM: 609842; Uniprot ID:EDC3_HUMAN; ENSEMBL ID: ENSG00000179151; HGNC ID: 26114
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst3 / 6231948
fetus35 / 56401262
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult82 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor6 / 34366174
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor3 / 17290173
gastrointestinal tumor3 / 11936925
germ cell tumor11 / 26384541
glioma9 / 10688384
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor10 / 96359103
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal147 / 336030743
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer102 / 102680993
retinoblastoma5 / 46356107
skin tumor10 / 12494980
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland0 / 331970 
ascites3 / 4001574
bladder2 / 2975767
blood6 / 12347848
bone5 / 7165569
bone marrow2 / 4880140
brain58 / 110098952
cervix6 / 48171124
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus3 / 20209148
eye14 / 21105466
heart3 / 8962633
intestine7 / 23447229
kidney15 / 21177770
larynx0 / 241450 
liver10 / 20774348
lung11 / 33697432
lymph2 / 4427045
lymph node1 / 9161010
mammary gland6 / 15327139
mouth2 / 6705229
muscle2 / 10771518
nerve1 / 1576863
ovary3 / 10205129
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate105 / 189345554
salivary gland0 / 201550 
skin14 / 21057466
spleen0 / 539520 
stomach4 / 9661941
testis18 / 33044254
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus12 / 23287851
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219207_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.25
Adipocyte6.55
AdrenalCortex7
Adrenalgland5.55
Amygdala6.7
Appendix6.7
AtrioventricularNode5.75
BDCA4+_DentriticCells6.6
Bonemarrow6.55
BronchialEpithelialCells6.55
CD105+_Endothelial6.7
CD14+_Monocytes6.7
CD19+_BCells(neg._sel.)6.65
CD33+_Myeloid7.8
CD34+8.5
CD4+_Tcells7.2
CD56+_NKCells8.85
CD71+_EarlyErythroid6.1
CD8+_Tcells5.8
CardiacMyocytes8.9
Caudatenucleus6.3
Cerebellum5.9
CerebellumPeduncles9.45
CiliaryGanglion5.2
CingulateCortex6.6
Colorectaladenocarcinoma5.95
DorsalRootGanglion5.5
FetalThyroid6.15
Fetalbrain6.35
Fetalliver5.75
Fetallung4.7
GlobusPallidus6.45
Heart8.1
Hypothalamus7.3
Kidney5.25
Leukemia_chronicMyelogenousK-5626.4
Leukemia_promyelocytic-HL-605.7
Leukemialymphoblastic(MOLT-4)7.2
Liver8.55
Lung7.5
Lymphnode5.1
Lymphoma_burkitts(Daudi)8.2
Lymphoma_burkitts(Raji)8.85
MedullaOblongata6.15
OccipitalLobe5.75
OlfactoryBulb4.95
Ovary4.7
Pancreas5.2
PancreaticIslet7.05
ParietalLobe8.1
Pituitary8.4
Placenta6.95
Pons9.15
PrefrontalCortex8.4
Prostate7.65
Salivarygland5.2
SkeletalMuscle7.4
Skin8.1
SmoothMuscle7.2
Spinalcord7
SubthalamicNucleus5.9
SuperiorCervicalGanglion7.65
TemporalLobe6
Testis21.7
TestisGermCell10.25
TestisIntersitial16.25
TestisLeydigCell12.5
TestisSeminiferousTubule10.6
Thalamus6.7
Thymus5.3
Thyroid7.45
Tongue6.5
Tonsil6.35
Trachea5.75
TrigeminalGanglion6.65
Uterus5.1
UterusCorpus5.75
WholeBlood7
Wholebrain7.3
colon6.5
pineal_day7.64
pineal_night7.64
retina8
small_intestine6.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P21155
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.44 ± 0.32
Basal Forebrain4.39 ± 0.43
Basal Part of Pons4.8 ± 0.19
Cerebellar Cortex4.4 ± 0.43
Cerebellar Nuclei4.55 ± 0.43
Claustrum4.41 ± 0.69
Epithalamus4.38 ± 0.39
Frontal Lobe4.87 ± 0.35
Globus Pallidus4.2 ± 0.47
Hypothalamus4.78 ± 0.49
Insula4.77 ± 0.28
Limbic Lobe4.65 ± 0.45
Mesencephalon4.56 ± 0.57
Myelencephalon4.58 ± 0.46
Occipital Lobe4.27 ± 0.46
Parietal Lobe4.63 ± 0.45
Pontine Tegmentum4.68 ± 0.43
Striatum4.48 ± 0.51
Subthalamus4.69 ± 0.42
Temporal Lobe4.7 ± 0.37
Thalamus4.56 ± 0.39
White Matter3.82 ± 0.77
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00006018 17 330 346 NVHQRPTVALLCGPHVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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