AutismKB 2.0

Annotation Detail for BRD3


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Basic Information Top
Gene Symbol:BRD3 ( FLJ23227,FLJ41328,KIAA0043,ORFX,RING3L )
Gene Full Name: bromodomain containing 3
Band: 9q34.2
Quick LinksEntrez ID:8019; OMIM: 601541; Uniprot ID:BRD3_HUMAN; ENSEMBL ID: ENSG00000169925; HGNC ID: 1104
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus52 / 56401292
neonate1 / 3109732
infant4 / 23620169
juvenile3 / 5555653
adult116 / 193912159
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult71 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor9 / 34366261
chondrosarcoma8 / 8282396
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor37 / 263845140
glioma12 / 106883112
head and neck tumor11 / 13630280
kidney tumor5 / 6895972
leukemia10 / 95842104
liver tumor3 / 9635931
lung tumor8 / 10312777
lymphoma4 / 7175555
non-neoplasia6 / 9725061
normal203 / 336030760
ovarian tumor6 / 7668278
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer3 / 10268029
retinoblastoma8 / 46356172
skin tumor1 / 1249498
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor4 / 9025744
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma7 / 10688365
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal122 / 336030736
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer1 / 1026809
retinoblastoma6 / 46356129
skin tumor10 / 12494980
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone6 / 7165583
bone marrow5 / 48801102
brain62 / 110098956
cervix9 / 48171186
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus1 / 2020949
eye32 / 211054151
heart2 / 8962622
intestine17 / 23447272
kidney18 / 21177784
larynx0 / 241450 
liver5 / 20774324
lung29 / 33697486
lymph3 / 4427067
lymph node19 / 91610207
mammary gland7 / 15327145
mouth2 / 6705229
muscle10 / 10771592
nerve3 / 15768190
ovary8 / 10205178
pancreas22 / 214812102
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate6 / 18934531
salivary gland3 / 20155148
skin7 / 21057433
spleen2 / 5395237
stomach4 / 9661941
testis30 / 33044290
thymus7 / 8113186
thyroid9 / 47473189
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone5 / 7165569
bone marrow2 / 4880140
brain45 / 110098940
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye23 / 211054108
heart1 / 8962611
intestine4 / 23447217
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung8 / 33697423
lymph1 / 4427022
lymph node4 / 9161043
mammary gland11 / 15327171
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary5 / 10205148
pancreas9 / 21481241
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate7 / 18934536
salivary gland4 / 20155198
skin15 / 21057471
spleen0 / 539520 
stomach1 / 9661910
testis8 / 33044224
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203825_at
Cell line Expression level Expression bar
721_B_lymphoblasts54.65
Adipocyte32.15
AdrenalCortex42.6
Adrenalgland48.45
Amygdala42.85
Appendix31.7
AtrioventricularNode20.85
BDCA4+_DentriticCells152.85
Bonemarrow69.65
BronchialEpithelialCells29.6
CD105+_Endothelial158.55
CD14+_Monocytes181.95
CD19+_BCells(neg._sel.)89.1
CD33+_Myeloid304.05
CD34+315.5
CD4+_Tcells87.7
CD56+_NKCells227
CD71+_EarlyErythroid148.9
CD8+_Tcells78.35
CardiacMyocytes30.25
Caudatenucleus15.85
Cerebellum75.5
CerebellumPeduncles89.8
CiliaryGanglion13
CingulateCortex48.95
Colorectaladenocarcinoma53.5
DorsalRootGanglion21.3
FetalThyroid101.15
Fetalbrain79.65
Fetalliver34.95
Fetallung29.35
GlobusPallidus29.25
Heart35.6
Hypothalamus36.15
Kidney21.85
Leukemia_chronicMyelogenousK-56229.15
Leukemia_promyelocytic-HL-6024.85
Leukemialymphoblastic(MOLT-4)78.8
Liver49.65
Lung224.5
Lymphnode24.4
Lymphoma_burkitts(Daudi)14.45
Lymphoma_burkitts(Raji)62.8
MedullaOblongata44.65
OccipitalLobe34.65
OlfactoryBulb46.55
Ovary15.8
Pancreas30.8
PancreaticIslet43.45
ParietalLobe38.7
Pituitary52.1
Placenta62.6
Pons40.55
PrefrontalCortex151.75
Prostate292.15
Salivarygland17.45
SkeletalMuscle36.5
Skin10.45
SmoothMuscle37.75
Spinalcord34.45
SubthalamicNucleus34.8
SuperiorCervicalGanglion36.55
TemporalLobe35.8
Testis46.95
TestisGermCell36
TestisIntersitial22.3
TestisLeydigCell33.15
TestisSeminiferousTubule31.65
Thalamus23
Thymus163.4
Thyroid61.55
Tongue30.95
Tonsil30.7
Trachea25.65
TrigeminalGanglion31.55
Uterus193.05
UterusCorpus29.75
WholeBlood42.8
Wholebrain100.65
colon36.95
pineal_day167.66
pineal_night171.54
retina89.9
small_intestine35.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P32887
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.94 ± 0.26
Basal Forebrain9.07 ± 0.3
Basal Part of Pons8.57 ± 0.25
Cerebellar Cortex8.77 ± 0.15
Cerebellar Nuclei8.7 ± 0.19
Claustrum9.24 ± 0.29
Epithalamus9.01 ± 0.17
Frontal Lobe8.66 ± 0.3
Globus Pallidus9.46 ± 0.12
Hypothalamus8.66 ± 0.32
Insula8.73 ± 0.32
Limbic Lobe8.81 ± 0.35
Mesencephalon8.86 ± 0.36
Myelencephalon8.85 ± 0.34
Occipital Lobe9.02 ± 0.36
Parietal Lobe8.82 ± 0.31
Pontine Tegmentum8.77 ± 0.28
Striatum8.86 ± 0.32
Subthalamus8.71 ± 0.27
Temporal Lobe8.79 ± 0.26
Thalamus8.83 ± 0.23
White Matter9.87 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Brd3CBCerebellum8.95
10.52
Brd3CTXCerebral cortex36.39
28.94
Brd3HIPHippocampal region34.06
38.25
Brd3HPFHippocampal formation44.97
45.92
Brd3HYHypothalamus38.01
34.1
Brd3LSXLateral septal complex5.44
3.92
Brd3MBMidbrain7.46
7.2
Brd3MYMedulla12.24
13.89
Brd3OLFOlfactory bulb53.77
45.38
Brd3PPons15.96
17.81
Brd3PALPallidum19.69
18.78
Brd3RHPRetrohippocampal region66.41
59.54
Brd3sAMYStriatum-like amygdalar nuclei20.82
15.06
Brd3STRStriatum10.87
9.08
Brd3STRdStriatum dorsal region5.04
4.79
Brd3STRvStriatum ventral region29.79
22.9
Brd3THThalamus5.7
5.03
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064269 18 472 489 AVHEQLAALSQAPVNKPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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