AutismKB 2.0

Annotation Detail for MUS81


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Basic Information Top
Gene Symbol:MUS81 ( FLJ21012,FLJ44872,SLX3 )
Gene Full Name: MUS81 endonuclease homolog (S. cerevisiae)
Band: 11q13
Quick LinksEntrez ID:80198; OMIM: 606591; Uniprot ID:MUS81_HUMAN; ENSEMBL ID: ENSG00000172732; HGNC ID: 29814
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus46 / 56401281
neonate0 / 310970 
infant1 / 2362042
juvenile3 / 5555653
adult75 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor13 / 26384549
glioma14 / 106883130
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor5 / 9635951
lung tumor2 / 10312719
lymphoma11 / 71755153
non-neoplasia9 / 9725092
normal172 / 336030751
ovarian tumor3 / 7668239
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland4 / 33197120
ascites3 / 4001574
bladder1 / 2975733
blood3 / 12347824
bone6 / 7165583
bone marrow5 / 48801102
brain87 / 110098979
cervix4 / 4817183
connective tissue12 / 14925580
ear2 / 16212123
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye2 / 2110549
heart6 / 8962666
intestine12 / 23447251
kidney14 / 21177766
larynx0 / 241450 
liver6 / 20774328
lung13 / 33697438
lymph4 / 4427090
lymph node15 / 91610163
mammary gland7 / 15327145
mouth7 / 67052104
muscle0 / 1077150 
nerve1 / 1576863
ovary4 / 10205139
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate3 / 18934515
salivary gland3 / 20155148
skin9 / 21057442
spleen2 / 5395237
stomach3 / 9661931
testis11 / 33044233
thymus10 / 81131123
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus15 / 23287864
vascular9 / 51780173
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218463_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts83.95
Adipocyte13.5
AdrenalCortex13.9
Adrenalgland10.05
Amygdala14.45
Appendix13.35
AtrioventricularNode14.15
BDCA4+_DentriticCells54.15
Bonemarrow13.15
BronchialEpithelialCells13.5
CD105+_Endothelial27.55
CD14+_Monocytes73.75
CD19+_BCells(neg._sel.)48.7
CD33+_Myeloid33.55
CD34+77.9
CD4+_Tcells123.65
CD56+_NKCells146.2
CD71+_EarlyErythroid19.05
CD8+_Tcells140.85
CardiacMyocytes17.2
Caudatenucleus12.8
Cerebellum10.9
CerebellumPeduncles15.25
CiliaryGanglion9.35
CingulateCortex13.65
Colorectaladenocarcinoma14.75
DorsalRootGanglion10.2
FetalThyroid15.55
Fetalbrain13.55
Fetalliver11.25
Fetallung12.8
GlobusPallidus9.85
Heart25.45
Hypothalamus15.1
Kidney10.65
Leukemia_chronicMyelogenousK-56215.35
Leukemia_promyelocytic-HL-6011.95
Leukemialymphoblastic(MOLT-4)28.6
Liver17.9
Lung15.9
Lymphnode13
Lymphoma_burkitts(Daudi)19.2
Lymphoma_burkitts(Raji)21.25
MedullaOblongata9.95
OccipitalLobe13.65
OlfactoryBulb10.95
Ovary8.9
Pancreas9.35
PancreaticIslet14.65
ParietalLobe13.35
Pituitary11.75
Placenta14.2
Pons12.85
PrefrontalCortex17.1
Prostate15.9
Salivarygland9.55
SkeletalMuscle15.5
Skin12.45
SmoothMuscle13.6
Spinalcord14.5
SubthalamicNucleus11.1
SuperiorCervicalGanglion11.95
TemporalLobe10.55
Testis10.8
TestisGermCell11.95
TestisIntersitial11.15
TestisLeydigCell11.85
TestisSeminiferousTubule11.6
Thalamus13.7
Thymus14.6
Thyroid21.55
Tongue12.75
Tonsil13.3
Trachea8.65
TrigeminalGanglion11.15
Uterus13.4
UterusCorpus10.15
WholeBlood16.95
Wholebrain14.6
colon13.1
pineal_day40.6
pineal_night30.94
retina16.275
small_intestine11.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P412238
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.11 ± 0.75
Basal Forebrain5.47 ± 0.34
Basal Part of Pons5.95 ± 0.44
Cerebellar Cortex6.06 ± 0.45
Cerebellar Nuclei5.3 ± 0.59
Claustrum4.69 ± 1.1
Epithalamus6.15 ± 0.64
Frontal Lobe5.69 ± 0.51
Globus Pallidus5.23 ± 0.16
Hypothalamus5.17 ± 0.58
Insula5.67 ± 0.46
Limbic Lobe5.4 ± 0.65
Mesencephalon5.42 ± 0.62
Myelencephalon5.55 ± 0.59
Occipital Lobe5.29 ± 0.55
Parietal Lobe5.56 ± 0.61
Pontine Tegmentum5.45 ± 0.6
Striatum5.17 ± 0.46
Subthalamus5.6 ± 0.4
Temporal Lobe5.68 ± 0.64
Thalamus5.7 ± 0.51
White Matter6.03 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mus81CBCerebellum100
100
Mus81CTXCerebral cortex100
100
Mus81HIPHippocampal region100
100
Mus81HPFHippocampal formation100
100
Mus81HYHypothalamus100
100
Mus81LSXLateral septal complex100
100
Mus81MBMidbrain100
100
Mus81MYMedulla100
100
Mus81OLFOlfactory bulb100
100
Mus81PPons100
100
Mus81PALPallidum100
100
Mus81RHPRetrohippocampal region100
100
Mus81sAMYStriatum-like amygdalar nuclei100
100
Mus81STRStriatum100
100
Mus81STRdStriatum dorsal region100
100
Mus81STRvStriatum ventral region100
100
Mus81THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00496066 22 86 107 TSGGDHAPDSPSGENSPAPQGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018