AutismKB 2.0

Annotation Detail for ALPK1


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Basic Information Top
Gene Symbol:ALPK1 ( 8430410J10Rik,FLJ22670,KIAA1527,LAK )
Gene Full Name: alpha-kinase 1
Band: 4q25
Quick LinksEntrez ID:80216; OMIM: 607347; Uniprot ID:ALPK1_HUMAN; ENSEMBL ID: ENSG00000073331; HGNC ID: 20917
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult44 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal68 / 336030720
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood7 / 12347856
bone1 / 7165513
bone marrow0 / 488010 
brain13 / 110098911
cervix1 / 4817120
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine9 / 23447238
kidney4 / 21177718
larynx0 / 241450 
liver7 / 20774333
lung5 / 33697414
lymph0 / 442700 
lymph node9 / 9161098
mammary gland4 / 15327126
mouth2 / 6705229
muscle4 / 10771537
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta5 / 28082517
prostate4 / 18934521
salivary gland0 / 201550 
skin2 / 2105749
spleen4 / 5395274
stomach5 / 9661951
testis1 / 3304423
thymus4 / 8113149
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P133133
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.6 ± 0.95
Basal Forebrain2.32 ± 0.42
Basal Part of Pons3.47 ± 0.72
Cerebellar Cortex2.46 ± 0.4
Cerebellar Nuclei3.13 ± 0.53
Claustrum2.83 ± 0.89
Epithalamus3.34 ± 0.81
Frontal Lobe3.2 ± 0.91
Globus Pallidus3.8 ± 0.89
Hypothalamus2.24 ± 0.56
Insula3.06 ± 0.94
Limbic Lobe4.1 ± 1.27
Mesencephalon2.97 ± 0.74
Myelencephalon3.23 ± 0.88
Occipital Lobe3.1 ± 0.91
Parietal Lobe3.33 ± 0.98
Pontine Tegmentum3.13 ± 0.83
Striatum5.45 ± 0.98
Subthalamus2.87 ± 0.62
Temporal Lobe3.06 ± 0.91
Thalamus2.65 ± 0.72
White Matter2.4 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Alpk1CBCerebellum1.24
1.52
Alpk1CTXCerebral cortex0.93
1.36
Alpk1HIPHippocampal region1.37
1.44
Alpk1HPFHippocampal formation0.95
0.94
Alpk1HYHypothalamus1.6
2.62
Alpk1LSXLateral septal complex0.14
0.28
Alpk1MBMidbrain0.49
0.88
Alpk1MYMedulla4.69
6.86
Alpk1OLFOlfactory bulb1.14
2.15
Alpk1PPons0.15
0.29
Alpk1PALPallidum0.33
0.73
Alpk1RHPRetrohippocampal region0.23
0.24
Alpk1sAMYStriatum-like amygdalar nuclei1.25
1.39
Alpk1STRStriatum0.36
0.49
Alpk1STRdStriatum dorsal region0.34
0.52
Alpk1STRvStriatum ventral region0.08
0.07
Alpk1THThalamus1.06
1.89
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018