AutismKB 2.0

Annotation Detail for PLEKHO2


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Basic Information Top
Gene Symbol:PLEKHO2 ( DKFZp761K2312,FLJ38884,PLEKHQ1,PP1628,pp9099 )
Gene Full Name: pleckstrin homology domain containing, family O member 2
Band: 15q22.31
Quick LinksEntrez ID:80301; OMIM: NA; Uniprot ID:PKHO2_HUMAN; ENSEMBL ID: ENSG00000166839,ENSG00000241839; HGNC ID: 30026
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult64 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma13 / 82823156
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor9 / 26384534
glioma8 / 10688374
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal88 / 336030726
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor13 / 124949104
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone4 / 7165555
bone marrow0 / 488010 
brain18 / 110098916
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye6 / 21105428
heart3 / 8962633
intestine6 / 23447225
kidney7 / 21177733
larynx0 / 241450 
liver0 / 2077430 
lung19 / 33697456
lymph1 / 4427022
lymph node6 / 9161065
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate0 / 1893450 
salivary gland0 / 201550 
skin15 / 21057471
spleen4 / 5395274
stomach1 / 9661910
testis7 / 33044221
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204436_at
Cell line Expression level Expression bar
721_B_lymphoblasts42
Adipocyte54.45
AdrenalCortex52.15
Adrenalgland60
Amygdala37.2
Appendix35.95
AtrioventricularNode25.1
BDCA4+_DentriticCells36.7
Bonemarrow76.05
BronchialEpithelialCells34.7
CD105+_Endothelial10
CD14+_Monocytes154.15
CD19+_BCells(neg._sel.)31.65
CD33+_Myeloid40.9
CD34+17.3
CD4+_Tcells40.25
CD56+_NKCells83.8
CD71+_EarlyErythroid8.85
CD8+_Tcells33.4
CardiacMyocytes66.65
Caudatenucleus17.65
Cerebellum32.35
CerebellumPeduncles39.65
CiliaryGanglion23.25
CingulateCortex36.7
Colorectaladenocarcinoma34.2
DorsalRootGanglion25.55
FetalThyroid58.85
Fetalbrain25.95
Fetalliver29.55
Fetallung42.45
GlobusPallidus10.95
Heart216.7
Hypothalamus38.9
Kidney27.55
Leukemia_chronicMyelogenousK-56227.55
Leukemia_promyelocytic-HL-6029.5
Leukemialymphoblastic(MOLT-4)24.75
Liver48.55
Lung54.9
Lymphnode82.35
Lymphoma_burkitts(Daudi)43.9
Lymphoma_burkitts(Raji)47.05
MedullaOblongata31.6
OccipitalLobe25.9
OlfactoryBulb28.95
Ovary22.6
Pancreas29.75
PancreaticIslet32.2
ParietalLobe35.35
Pituitary41.95
Placenta61.85
Pons43.95
PrefrontalCortex43.55
Prostate40.45
Salivarygland27.15
SkeletalMuscle28.65
Skin25.65
SmoothMuscle39.4
Spinalcord34.9
SubthalamicNucleus17.55
SuperiorCervicalGanglion37.85
TemporalLobe32.25
Testis34.65
TestisGermCell25.8
TestisIntersitial31.25
TestisLeydigCell38.45
TestisSeminiferousTubule29.6
Thalamus21.95
Thymus45.65
Thyroid119.3
Tongue32.85
Tonsil51.75
Trachea41.35
TrigeminalGanglion34.5
Uterus28.6
UterusCorpus30.2
WholeBlood399.5
Wholebrain30.15
colon33.25
pineal_day19.96
pineal_night27.12
retina75.225
small_intestine30.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9625_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.45 ± 1.19
Basal Forebrain3.37 ± 0.62
Basal Part of Pons2.46 ± 0.52
Cerebellar Cortex2.74 ± 0.74
Cerebellar Nuclei3.19 ± 0.85
Claustrum3.43 ± 0.88
Epithalamus2.62 ± 0.57
Frontal Lobe2.86 ± 0.8
Globus Pallidus3.98 ± 0.77
Hypothalamus3.05 ± 0.71
Insula2.61 ± 0.83
Limbic Lobe2.95 ± 0.78
Mesencephalon3.26 ± 0.85
Myelencephalon2.99 ± 0.75
Occipital Lobe3.09 ± 0.8
Parietal Lobe2.99 ± 0.82
Pontine Tegmentum3.05 ± 0.87
Striatum3.16 ± 0.79
Subthalamus3.03 ± 0.21
Temporal Lobe2.82 ± 0.87
Thalamus3.04 ± 0.76
White Matter4.07 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plekhq1CBCerebellum15.03
30.09
Plekhq1CTXCerebral cortex7.38
5.36
Plekhq1HIPHippocampal region10.8
9.76
Plekhq1HPFHippocampal formation8.26
7.24
Plekhq1HYHypothalamus0.57
0.63
Plekhq1LSXLateral septal complex0.48
0.27
Plekhq1MBMidbrain1.61
2.76
Plekhq1MYMedulla2.36
2.91
Plekhq1OLFOlfactory bulb5.1
4.44
Plekhq1PPons2.33
3.44
Plekhq1PALPallidum0.88
0.71
Plekhq1RHPRetrohippocampal region4.2
3.91
Plekhq1sAMYStriatum-like amygdalar nuclei1.38
0.86
Plekhq1STRStriatum0.92
0.71
Plekhq1STRdStriatum dorsal region0.95
0.81
Plekhq1STRvStriatum ventral region0.82
0.53
Plekhq1THThalamus2.18
1.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00037971 26 342 367 SVNGMDDSPEPAKPSQAEGTPGTPPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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