AutismKB 2.0

Annotation Detail for NCOA4


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Basic Information Top
Gene Symbol:NCOA4 ( ARA70,DKFZp762E1112,ELE1,PTC3,RFG )
Gene Full Name: nuclear receptor coactivator 4
Band: 10q11.22
Quick LinksEntrez ID:8031; OMIM: 601984; Uniprot ID:NCOA4_HUMAN; ENSEMBL ID: ENSG00000138293; HGNC ID: 7671
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst9 / 62319144
fetus226 / 564012400
neonate15 / 31097482
infant1 / 2362042
juvenile24 / 55556431
adult401 / 1939121206
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult10 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma8 / 17475457
breast (mammary gland) tumor9 / 9417895
cervical tumor7 / 34366203
chondrosarcoma9 / 82823108
colorectal tumor15 / 114246131
esophageal tumor1 / 1729057
gastrointestinal tumor11 / 11936992
germ cell tumor85 / 263845322
glioma11 / 106883102
head and neck tumor68 / 136302498
kidney tumor16 / 68959232
leukemia22 / 95842229
liver tumor39 / 96359404
lung tumor9 / 10312787
lymphoma10 / 71755139
non-neoplasia49 / 97250503
normal1093 / 3360307325
ovarian tumor7 / 7668291
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer60 / 102680584
retinoblastoma5 / 46356107
skin tumor9 / 12494972
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor22 / 90257243
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal15 / 33603074
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland9 / 33197271
ascites8 / 40015199
bladder8 / 29757268
blood69 / 123478558
bone13 / 71655181
bone marrow22 / 48801450
brain560 / 1100989508
cervix7 / 48171145
connective tissue46 / 149255308
ear5 / 16212308
embryonic tissue38 / 215722176
esophagus3 / 20209148
eye21 / 21105499
heart18 / 89626200
intestine27 / 234472115
kidney53 / 211777250
larynx2 / 2414582
liver68 / 207743327
lung52 / 336974154
lymph6 / 44270135
lymph node20 / 91610218
mammary gland24 / 153271156
mouth59 / 67052879
muscle9 / 10771583
nerve2 / 15768126
ovary7 / 10205168
pancreas30 / 214812139
parathyroid4 / 20539194
pharynx9 / 41328217
pituitary gland3 / 16585180
placenta109 / 280825388
prostate79 / 189345417
salivary gland3 / 20155148
skin42 / 210574199
spleen24 / 53952444
stomach7 / 9661972
testis148 / 330442447
thymus83 / 811311023
thyroid9 / 47473189
tonsil0 / 169990 
trachea180 / 524133434
umbilical cord1 / 1368073
uterus62 / 232878266
vascular18 / 51780347
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine0 / 2344720 
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary2 / 10205119
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland1 / 2015549
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210774_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1111.15
Adipocyte870.3
AdrenalCortex169.1
Adrenalgland264.95
Amygdala397.75
Appendix117
AtrioventricularNode42.7
BDCA4+_DentriticCells2644.15
Bonemarrow1759.7
BronchialEpithelialCells819.65
CD105+_Endothelial1722.7
CD14+_Monocytes3309.2
CD19+_BCells(neg._sel.)1163.8
CD33+_Myeloid3243.4
CD34+2370.4
CD4+_Tcells1010.05
CD56+_NKCells1786.7
CD71+_EarlyErythroid8024.05
CD8+_Tcells895
CardiacMyocytes275.1
Caudatenucleus274
Cerebellum84.75
CerebellumPeduncles184.3
CiliaryGanglion74.05
CingulateCortex202.9
Colorectaladenocarcinoma129.9
DorsalRootGanglion70.45
FetalThyroid483.45
Fetalbrain400.65
Fetalliver2224.1
Fetallung763.15
GlobusPallidus79.75
Heart79.6
Hypothalamus692.7
Kidney280.35
Leukemia_chronicMyelogenousK-562772.85
Leukemia_promyelocytic-HL-60280.35
Leukemialymphoblastic(MOLT-4)468.8
Liver145.3
Lung170.75
Lymphnode466.75
Lymphoma_burkitts(Daudi)450.1
Lymphoma_burkitts(Raji)186.85
MedullaOblongata254.75
OccipitalLobe336.65
OlfactoryBulb289.9
Ovary69.05
Pancreas216.75
PancreaticIslet387.7
ParietalLobe210.05
Pituitary440.95
Placenta1061.1
Pons120.85
PrefrontalCortex616.25
Prostate1255.6
Salivarygland458.6
SkeletalMuscle107.3
Skin103.55
SmoothMuscle789.6
Spinalcord603.95
SubthalamicNucleus174.75
SuperiorCervicalGanglion63.2
TemporalLobe164.05
Testis90.95
TestisGermCell243.45
TestisIntersitial105.3
TestisLeydigCell135.9
TestisSeminiferousTubule58.8
Thalamus274.45
Thymus405.35
Thyroid802.45
Tongue225.25
Tonsil696
Trachea344.6
TrigeminalGanglion54.5
Uterus463.35
UterusCorpus136
WholeBlood5616.4
Wholebrain271.25
colon982.05
pineal_day357.54
pineal_night369
retina686.05
small_intestine1466.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P86424
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.8 ± 0.17
Basal Forebrain10.08 ± 0.19
Basal Part of Pons10.09 ± 0.15
Cerebellar Cortex9.82 ± 0.19
Cerebellar Nuclei10.57 ± 0.21
Claustrum9.97 ± 0.27
Epithalamus10.07 ± 0.2
Frontal Lobe9.99 ± 0.31
Globus Pallidus10.75 ± 0.24
Hypothalamus10.28 ± 0.12
Insula9.82 ± 0.32
Limbic Lobe9.89 ± 0.32
Mesencephalon10.22 ± 0.26
Myelencephalon10.03 ± 0.29
Occipital Lobe10.15 ± 0.18
Parietal Lobe10.09 ± 0.27
Pontine Tegmentum10.08 ± 0.26
Striatum10.06 ± 0.25
Subthalamus10.47 ± 0.14
Temporal Lobe9.95 ± 0.24
Thalamus10.16 ± 0.19
White Matter10.94 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ncoa4CBCerebellum10.22
9.74
Ncoa4CTXCerebral cortex0.72
0.51
Ncoa4HIPHippocampal region13.57
6.1
Ncoa4HPFHippocampal formation7.92
3.39
Ncoa4HYHypothalamus1.04
0.6
Ncoa4LSXLateral septal complex0.69
0.37
Ncoa4MBMidbrain1.64
1.25
Ncoa4MYMedulla6.55
5.55
Ncoa4OLFOlfactory bulb2.24
1.65
Ncoa4PPons4.04
3.44
Ncoa4PALPallidum1.41
1.08
Ncoa4RHPRetrohippocampal region0.74
0.45
Ncoa4sAMYStriatum-like amygdalar nuclei0.25
0.15
Ncoa4STRStriatum0.35
0.23
Ncoa4STRdStriatum dorsal region0.24
0.17
Ncoa4STRvStriatum ventral region0.59
0.36
Ncoa4THThalamus2.67
1.25
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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