AutismKB 2.0

Annotation Detail for CXXC4


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Basic Information Top
Gene Symbol:CXXC4 ( IDAX,MGC149872 )
Gene Full Name: CXXC finger protein 4
Band: 4q24
Quick LinksEntrez ID:80319; OMIM: 611645; Uniprot ID:CXXC4_HUMAN; ENSEMBL ID: ENSG00000168772; HGNC ID: 24593
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal61 / 336030718
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain22 / 110098919
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine1 / 2344724
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220277_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.3
Adipocyte3.25
AdrenalCortex3.45
Adrenalgland2.8
Amygdala3.55
Appendix3.3
AtrioventricularNode2.55
BDCA4+_DentriticCells3.7
Bonemarrow3.25
BronchialEpithelialCells3.25
CD105+_Endothelial3.35
CD14+_Monocytes3.6
CD19+_BCells(neg._sel.)3.6
CD33+_Myeloid4.25
CD34+4.25
CD4+_Tcells3.6
CD56+_NKCells4.05
CD71+_EarlyErythroid3.1
CD8+_Tcells3.2
CardiacMyocytes4.15
Caudatenucleus2.95
Cerebellum2.7
CerebellumPeduncles3.8
CiliaryGanglion2.3
CingulateCortex4.5
Colorectaladenocarcinoma3.35
DorsalRootGanglion2.5
FetalThyroid3.25
Fetalbrain24.65
Fetalliver2.9
Fetallung2.7
GlobusPallidus2.45
Heart4.2
Hypothalamus3.65
Kidney2.65
Leukemia_chronicMyelogenousK-5622.95
Leukemia_promyelocytic-HL-602.9
Leukemialymphoblastic(MOLT-4)2.7
Liver4.35
Lung3.7
Lymphnode2.9
Lymphoma_burkitts(Daudi)4.25
Lymphoma_burkitts(Raji)4.6
MedullaOblongata3.05
OccipitalLobe3
OlfactoryBulb2.65
Ovary2.2
Pancreas2.7
PancreaticIslet3.55
ParietalLobe3.45
Pituitary4.75
Placenta3.4
Pons3.15
PrefrontalCortex4.95
Prostate3.9
Salivarygland2.6
SkeletalMuscle3.75
Skin2.55
SmoothMuscle3.75
Spinalcord3.55
SubthalamicNucleus3.35
SuperiorCervicalGanglion3.7
TemporalLobe3.1
Testis2.85
TestisGermCell2.8
TestisIntersitial2.8
TestisLeydigCell3.25
TestisSeminiferousTubule2.9
Thalamus3.35
Thymus2.65
Thyroid4.2
Tongue3.2
Tonsil3.2
Trachea2.8
TrigeminalGanglion3.25
Uterus2.75
UterusCorpus2.95
WholeBlood3.6
Wholebrain3.8
colon3.35
pineal_day21.3
pineal_night12.18
retina4.275
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15972_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.19 ± 0.55
Basal Forebrain4.78 ± 0.21
Basal Part of Pons4.16 ± 0.46
Cerebellar Cortex3.73 ± 0.51
Cerebellar Nuclei4.31 ± 0.48
Claustrum3.7 ± 0.96
Epithalamus5.22 ± 0.46
Frontal Lobe4.58 ± 0.52
Globus Pallidus4.53 ± 0.51
Hypothalamus5.35 ± 0.51
Insula4.79 ± 0.3
Limbic Lobe4.16 ± 0.7
Mesencephalon4.76 ± 0.61
Myelencephalon4.43 ± 0.62
Occipital Lobe3.98 ± 0.73
Parietal Lobe4.38 ± 0.53
Pontine Tegmentum4.44 ± 0.47
Striatum4.21 ± 0.83
Subthalamus4.95 ± 0.71
Temporal Lobe4.61 ± 0.43
Thalamus4.45 ± 0.39
White Matter4.03 ± 0.91
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cxxc4CBCerebellum1.11
1.76
Cxxc4CTXCerebral cortex2.6
2.18
Cxxc4HIPHippocampal region0.95
0.93
Cxxc4HPFHippocampal formation2.53
2.29
Cxxc4HYHypothalamus0.85
0.72
Cxxc4LSXLateral septal complex0.25
0.35
Cxxc4MBMidbrain2.03
1.9
Cxxc4MYMedulla1.29
1.48
Cxxc4OLFOlfactory bulb1.3
1.57
Cxxc4PPons1.36
1.44
Cxxc4PALPallidum0.62
0.45
Cxxc4RHPRetrohippocampal region5.14
4.14
Cxxc4sAMYStriatum-like amygdalar nuclei0.41
0.23
Cxxc4STRStriatum0.68
0.71
Cxxc4STRdStriatum dorsal region0.88
0.8
Cxxc4STRvStriatum ventral region0.28
0.8
Cxxc4THThalamus0.66
0.69
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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