AutismKB 2.0

Annotation Detail for CUL5


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Basic Information Top
Gene Symbol:CUL5 ( VACM-1,VACM1 )
Gene Full Name: cullin 5
Band: 11q22.3
Quick LinksEntrez ID:8065; OMIM: 601741; Uniprot ID:CUL5_HUMAN; ENSEMBL ID: ENSG00000166266; HGNC ID: 2556
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst2 / 6231932
fetus36 / 56401263
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult76 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor4 / 10312738
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal146 / 336030743
ovarian tumor4 / 7668252
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder2 / 2975767
blood2 / 12347816
bone2 / 7165527
bone marrow2 / 4880140
brain41 / 110098937
cervix0 / 481710 
connective tissue1 / 1492556
ear2 / 16212123
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye4 / 21105418
heart2 / 8962622
intestine7 / 23447229
kidney12 / 21177756
larynx0 / 241450 
liver7 / 20774333
lung15 / 33697444
lymph0 / 442700 
lymph node8 / 9161087
mammary gland2 / 15327113
mouth4 / 6705259
muscle8 / 10771574
nerve1 / 1576863
ovary4 / 10205139
pancreas17 / 21481279
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta14 / 28082549
prostate7 / 18934536
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach2 / 9661920
testis9 / 33044227
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203533_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.4
Adipocyte22.25
AdrenalCortex34.2
Adrenalgland24.3
Amygdala44.9
Appendix34.5
AtrioventricularNode24.3
BDCA4+_DentriticCells29.15
Bonemarrow30.15
BronchialEpithelialCells23.1
CD105+_Endothelial30.6
CD14+_Monocytes33.4
CD19+_BCells(neg._sel.)43.3
CD33+_Myeloid34.25
CD34+33.2
CD4+_Tcells27.15
CD56+_NKCells32.75
CD71+_EarlyErythroid26.95
CD8+_Tcells26
CardiacMyocytes43.85
Caudatenucleus25.9
Cerebellum22.1
CerebellumPeduncles37.9
CiliaryGanglion29.5
CingulateCortex30.6
Colorectaladenocarcinoma27.2
DorsalRootGanglion27.05
FetalThyroid47.2
Fetalbrain39.2
Fetalliver24.85
Fetallung29.25
GlobusPallidus23.45
Heart38.95
Hypothalamus31.55
Kidney25.6
Leukemia_chronicMyelogenousK-56224.45
Leukemia_promyelocytic-HL-6025.15
Leukemialymphoblastic(MOLT-4)27
Liver41.8
Lung26.85
Lymphnode23.05
Lymphoma_burkitts(Daudi)36
Lymphoma_burkitts(Raji)43.95
MedullaOblongata26.75
OccipitalLobe34.95
OlfactoryBulb32.35
Ovary16.4
Pancreas24.05
PancreaticIslet31.5
ParietalLobe34.25
Pituitary39.05
Placenta24.55
Pons27.8
PrefrontalCortex70.1
Prostate46.85
Salivarygland24.9
SkeletalMuscle62.1
Skin23.2
SmoothMuscle29.05
Spinalcord31.9
SubthalamicNucleus28.85
SuperiorCervicalGanglion48.5
TemporalLobe27.4
Testis22.05
TestisGermCell22.2
TestisIntersitial23.95
TestisLeydigCell28.9
TestisSeminiferousTubule24
Thalamus29.1
Thymus20.6
Thyroid39.85
Tongue49.05
Tonsil28.25
Trachea22
TrigeminalGanglion29.4
Uterus94.1
UterusCorpus35.85
WholeBlood27.25
Wholebrain21.55
colon30.5
pineal_day58.7
pineal_night55.42
retina31.15
small_intestine26.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P203009
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.37 ± 0.39
Basal Forebrain7.24 ± 0.13
Basal Part of Pons7.47 ± 0.34
Cerebellar Cortex7.52 ± 0.3
Cerebellar Nuclei7.57 ± 0.26
Claustrum7.71 ± 0.42
Epithalamus7.4 ± 0.26
Frontal Lobe7.42 ± 0.28
Globus Pallidus7.16 ± 0.21
Hypothalamus7.51 ± 0.25
Insula7.36 ± 0.26
Limbic Lobe7.51 ± 0.34
Mesencephalon7.44 ± 0.33
Myelencephalon7.42 ± 0.3
Occipital Lobe7.77 ± 0.23
Parietal Lobe7.5 ± 0.24
Pontine Tegmentum7.48 ± 0.25
Striatum7.51 ± 0.23
Subthalamus7.51 ± 0.12
Temporal Lobe7.36 ± 0.25
Thalamus7.47 ± 0.26
White Matter7.56 ± 0.14
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00065107 27 313 339 DLEEHIISAGLADMVAAAETITTDSEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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