AutismKB 2.0

Annotation Detail for PTP4A2


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Basic Information Top
Gene Symbol:PTP4A2 ( HH13,HH7-2,HU-PP-1,OV-1,PRL-2,PRL2,PTP4A,PTPCAAX2,ptp-IV1a,ptp-IV1b )
Gene Full Name: protein tyrosine phosphatase type IVA, member 2
Band: 1p35.2
Quick LinksEntrez ID:8073; OMIM: 601584; Uniprot ID:TP4A2_HUMAN; ENSEMBL ID: ENSG00000184007; HGNC ID: 9635
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst8 / 62319128
fetus75 / 564012132
neonate1 / 3109732
infant1 / 2362042
juvenile6 / 55556107
adult296 / 1939121152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor10 / 94178106
cervical tumor3 / 3436687
chondrosarcoma32 / 82823386
colorectal tumor17 / 114246148
esophageal tumor1 / 1729057
gastrointestinal tumor17 / 119369142
germ cell tumor17 / 26384564
glioma9 / 10688384
head and neck tumor5 / 13630236
kidney tumor6 / 6895987
leukemia28 / 95842292
liver tumor12 / 96359124
lung tumor8 / 10312777
lymphoma6 / 7175583
non-neoplasia12 / 97250123
normal375 / 3360307111
ovarian tumor9 / 76682117
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer17 / 102680165
retinoblastoma4 / 4635686
skin tumor11 / 12494988
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland2 / 3319760
ascites7 / 40015174
bladder3 / 29757100
blood29 / 123478234
bone21 / 71655293
bone marrow6 / 48801122
brain103 / 110098993
cervix3 / 4817162
connective tissue31 / 149255207
ear1 / 1621261
embryonic tissue24 / 215722111
esophagus1 / 2020949
eye39 / 211054184
heart18 / 89626200
intestine29 / 234472123
kidney12 / 21177756
larynx0 / 241450 
liver20 / 20774396
lung58 / 336974172
lymph5 / 44270112
lymph node16 / 91610174
mammary gland19 / 153271123
mouth1 / 6705214
muscle2 / 10771518
nerve2 / 15768126
ovary9 / 10205188
pancreas29 / 214812135
parathyroid4 / 20539194
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta21 / 28082574
prostate26 / 189345137
salivary gland2 / 2015599
skin26 / 210574123
spleen3 / 5395255
stomach14 / 96619144
testis29 / 33044287
thymus6 / 8113173
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus26 / 232878111
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208617_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts294.4
Adipocyte456.35
AdrenalCortex71
Adrenalgland71.95
Amygdala517.65
Appendix84.1
AtrioventricularNode36.35
BDCA4+_DentriticCells670.9
Bonemarrow104.6
BronchialEpithelialCells96.1
CD105+_Endothelial284.75
CD14+_Monocytes716.4
CD19+_BCells(neg._sel.)631.05
CD33+_Myeloid556.1
CD34+405.15
CD4+_Tcells757.15
CD56+_NKCells995.3
CD71+_EarlyErythroid338
CD8+_Tcells673.25
CardiacMyocytes262.9
Caudatenucleus311.55
Cerebellum63.7
CerebellumPeduncles231.65
CiliaryGanglion59.25
CingulateCortex445.55
Colorectaladenocarcinoma195.25
DorsalRootGanglion54.95
FetalThyroid271.55
Fetalbrain276.45
Fetalliver104.6
Fetallung221.1
GlobusPallidus78.4
Heart31.8
Hypothalamus1181.55
Kidney15.95
Leukemia_chronicMyelogenousK-562329.7
Leukemia_promyelocytic-HL-60183
Leukemialymphoblastic(MOLT-4)667.8
Liver23.15
Lung52.95
Lymphnode150.2
Lymphoma_burkitts(Daudi)359.2
Lymphoma_burkitts(Raji)169.05
MedullaOblongata456.35
OccipitalLobe418.5
OlfactoryBulb186.95
Ovary87.95
Pancreas149.85
PancreaticIslet235.6
ParietalLobe475.5
Pituitary230.95
Placenta94.65
Pons240.55
PrefrontalCortex942
Prostate310.85
Salivarygland158.75
SkeletalMuscle44.9
Skin78.5
SmoothMuscle449.85
Spinalcord493.1
SubthalamicNucleus233.35
SuperiorCervicalGanglion110.9
TemporalLobe151
Testis19.35
TestisGermCell113.2
TestisIntersitial93.85
TestisLeydigCell48.3
TestisSeminiferousTubule49.25
Thalamus394.45
Thymus451.55
Thyroid853.2
Tongue61.55
Tonsil230.85
Trachea126.4
TrigeminalGanglion27.05
Uterus160.5
UterusCorpus93.65
WholeBlood850.25
Wholebrain284.05
colon364.1
pineal_day592.38
pineal_night530.28
retina604.95
small_intestine373.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P94521
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.62 ± 0.81
Basal Forebrain4.41 ± 0.38
Basal Part of Pons4.2 ± 0.69
Cerebellar Cortex4.42 ± 0.53
Cerebellar Nuclei4.19 ± 0.64
Claustrum3.96 ± 1.08
Epithalamus4.15 ± 0.7
Frontal Lobe4.56 ± 0.62
Globus Pallidus5.74 ± 0.4
Hypothalamus4.4 ± 0.38
Insula4.52 ± 0.39
Limbic Lobe4.48 ± 0.53
Mesencephalon4.64 ± 0.74
Myelencephalon4.49 ± 0.6
Occipital Lobe4.21 ± 0.68
Parietal Lobe4.49 ± 0.5
Pontine Tegmentum4.64 ± 0.57
Striatum4.69 ± 0.53
Subthalamus4.29 ± 0.66
Temporal Lobe4.57 ± 0.54
Thalamus4.38 ± 0.57
White Matter5.69 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptp4a2CBCerebellum11.6
13.82
Ptp4a2CTXCerebral cortex32.15
25.38
Ptp4a2HIPHippocampal region34.61
46.38
Ptp4a2HPFHippocampal formation33.94
37.61
Ptp4a2HYHypothalamus11.39
8.83
Ptp4a2LSXLateral septal complex4.87
4.2
Ptp4a2MBMidbrain9.33
8.95
Ptp4a2MYMedulla16.93
19.46
Ptp4a2OLFOlfactory bulb33.1
26.19
Ptp4a2PPons13.6
15.42
Ptp4a2PALPallidum14.41
13.15
Ptp4a2RHPRetrohippocampal region32.95
25.91
Ptp4a2sAMYStriatum-like amygdalar nuclei14.2
9.92
Ptp4a2STRStriatum14.14
10.26
Ptp4a2STRdStriatum dorsal region13.65
10.28
Ptp4a2STRvStriatum ventral region19.4
12.13
Ptp4a2THThalamus9.27
8.02
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00008138 13 45 57 VCDATYDKAPVEK Peptide Atlas
TP4A2_HUMAN_0 0 0 0 APVLVALALIECGMK PRIDE
TP4A2_HUMAN_107 15 107 121 APVLVALALIECGMK PRIDE
TP4A2_HUMAN_44 13 44 56 VCDATYDKAPVEK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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