AutismKB 2.0

Annotation Detail for ITIH5


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Basic Information Top
Gene Symbol:ITIH5 ( DKFZp686F0145,ITI-HC5,MGC10848 )
Gene Full Name: inter-alpha (globulin) inhibitor H5
Band: 10p14
Quick LinksEntrez ID:80760; OMIM: 609783; Uniprot ID:ITIH5_HUMAN; ENSEMBL ID: ENSG00000123243; HGNC ID: 21449
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult155 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor17 / 26384564
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal210 / 336030762
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor23 / 124949184
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain64 / 110098958
cervix0 / 481710 
connective tissue1 / 1492556
ear2 / 16212123
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine5 / 23447221
kidney12 / 21177756
larynx0 / 241450 
liver4 / 20774319
lung2 / 3369745
lymph0 / 442700 
lymph node1 / 9161010
mammary gland7 / 15327145
mouth2 / 6705229
muscle5 / 10771546
nerve1 / 1576863
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta107 / 280825381
prostate1 / 1893455
salivary gland0 / 201550 
skin23 / 210574109
spleen0 / 539520 
stomach1 / 9661910
testis24 / 33044272
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus18 / 23287877
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219064_at
Cell line Expression level Expression bar
721_B_lymphoblasts6
Adipocyte12.25
AdrenalCortex4.95
Adrenalgland4.1
Amygdala5.25
Appendix25.85
AtrioventricularNode5.55
BDCA4+_DentriticCells4.9
Bonemarrow4.6
BronchialEpithelialCells4.4
CD105+_Endothelial5.3
CD14+_Monocytes4.95
CD19+_BCells(neg._sel.)4.95
CD33+_Myeloid5.9
CD34+6
CD4+_Tcells4.95
CD56+_NKCells5.25
CD71+_EarlyErythroid4.35
CD8+_Tcells4.5
CardiacMyocytes6.3
Caudatenucleus4.7
Cerebellum3.95
CerebellumPeduncles5.65
CiliaryGanglion3.9
CingulateCortex4.95
Colorectaladenocarcinoma4.8
DorsalRootGanglion5
FetalThyroid5.65
Fetalbrain4.8
Fetalliver4.05
Fetallung4.35
GlobusPallidus3.6
Heart7.25
Hypothalamus5.75
Kidney5.6
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604
Leukemialymphoblastic(MOLT-4)3.8
Liver6.5
Lung57.75
Lymphnode8.2
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)6.65
MedullaOblongata4.45
OccipitalLobe5.55
OlfactoryBulb27.9
Ovary3.45
Pancreas3.9
PancreaticIslet5.1
ParietalLobe5.15
Pituitary7.3
Placenta750.15
Pons4.7
PrefrontalCortex7.35
Prostate18.9
Salivarygland4
SkeletalMuscle7.6
Skin4.25
SmoothMuscle5.55
Spinalcord11.25
SubthalamicNucleus4.45
SuperiorCervicalGanglion6.2
TemporalLobe4.4
Testis4.4
TestisGermCell23.75
TestisIntersitial4.3
TestisLeydigCell4.85
TestisSeminiferousTubule4.75
Thalamus5.05
Thymus5.95
Thyroid55
Tongue4.9
Tonsil4.8
Trachea4
TrigeminalGanglion4.85
Uterus28.35
UterusCorpus5.75
WholeBlood5.15
Wholebrain7.85
colon9.65
pineal_day7.8
pineal_night15.36
retina31.175
small_intestine7.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P220855
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.22 ± 0.88
Basal Forebrain1.84 ± 0.29
Basal Part of Pons1.4 ± 0.36
Cerebellar Cortex1.53 ± 0.54
Cerebellar Nuclei2.41 ± 0.92
Claustrum2.61 ± 0.85
Epithalamus1.89 ± 0.47
Frontal Lobe1.67 ± 0.64
Globus Pallidus2.63 ± 0.9
Hypothalamus1.96 ± 0.67
Insula1.63 ± 0.64
Limbic Lobe1.78 ± 0.69
Mesencephalon2.01 ± 0.72
Myelencephalon1.85 ± 0.72
Occipital Lobe1.99 ± 0.71
Parietal Lobe1.8 ± 0.7
Pontine Tegmentum1.88 ± 0.65
Striatum2.22 ± 0.78
Subthalamus2.01 ± 0.78
Temporal Lobe1.72 ± 0.6
Thalamus1.8 ± 0.57
White Matter2.14 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Itih5CBCerebellum28.54
42.56
Itih5CTXCerebral cortex24.48
21.51
Itih5HIPHippocampal region20.57
29.93
Itih5HPFHippocampal formation21.67
29.18
Itih5HYHypothalamus13.75
17.41
Itih5LSXLateral septal complex7.66
8.96
Itih5MBMidbrain12.41
21.23
Itih5MYMedulla28.46
41.22
Itih5OLFOlfactory bulb47.42
44.63
Itih5PPons29.34
44.45
Itih5PALPallidum14.64
18.92
Itih5RHPRetrohippocampal region21.18
22.47
Itih5sAMYStriatum-like amygdalar nuclei38.99
34.6
Itih5STRStriatum18.49
17.85
Itih5STRdStriatum dorsal region14.77
14.91
Itih5STRvStriatum ventral region24.07
21.2
Itih5THThalamus16.37
22.05
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp01366590 15 170 184 YEHSISVRPQQLSGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018