AutismKB 2.0

Annotation Detail for CYB5B


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Basic Information Top
Gene Symbol:CYB5B ( CYB5-M,CYPB5M,DKFZp686M0619,OMB5 )
Gene Full Name: cytochrome b5 type B (outer mitochondrial membrane)
Band: 16q22.1
Quick LinksEntrez ID:80777; OMIM: 611964; Uniprot ID:CYB5B_HUMAN; ENSEMBL ID: ENSG00000103018; HGNC ID: 24374
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst12 / 62319192
fetus42 / 56401274
neonate2 / 3109764
infant8 / 23620338
juvenile17 / 55556305
adult183 / 193912194
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor9 / 9417895
cervical tumor9 / 34366261
chondrosarcoma3 / 8282336
colorectal tumor15 / 114246131
esophageal tumor1 / 1729057
gastrointestinal tumor34 / 119369284
germ cell tumor36 / 263845136
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor5 / 6895972
leukemia11 / 95842114
liver tumor15 / 96359155
lung tumor12 / 103127116
lymphoma18 / 71755250
non-neoplasia8 / 9725082
normal333 / 336030799
ovarian tumor4 / 7668252
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS21 / 125680167
prostate cancer5 / 10268048
retinoblastoma13 / 46356280
skin tumor15 / 124949120
soft tissue/muscle tissue tumor28 / 125191223
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland24 / 33197722
ascites8 / 40015199
bladder5 / 29757168
blood14 / 123478113
bone6 / 7165583
bone marrow3 / 4880161
brain98 / 110098989
cervix12 / 48171249
connective tissue16 / 149255107
ear1 / 1621261
embryonic tissue32 / 215722148
esophagus1 / 2020949
eye25 / 211054118
heart2 / 8962622
intestine39 / 234472166
kidney15 / 21177770
larynx0 / 241450 
liver24 / 207743115
lung23 / 33697468
lymph10 / 44270225
lymph node14 / 91610152
mammary gland9 / 15327158
mouth2 / 6705229
muscle11 / 107715102
nerve2 / 15768126
ovary7 / 10205168
pancreas16 / 21481274
parathyroid2 / 2053997
pharynx8 / 41328193
pituitary gland0 / 165850 
placenta50 / 280825178
prostate11 / 18934558
salivary gland0 / 201550 
skin24 / 210574113
spleen6 / 53952111
stomach18 / 96619186
testis29 / 33044287
thymus4 / 8113149
thyroid5 / 47473105
tonsil1 / 1699958
trachea9 / 52413171
umbilical cord1 / 1368073
uterus27 / 232878115
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201634_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts246.5
Adipocyte22.3
AdrenalCortex118.45
Adrenalgland148
Amygdala16.95
Appendix27.15
AtrioventricularNode29.55
BDCA4+_DentriticCells32.95
Bonemarrow22.7
BronchialEpithelialCells70.4
CD105+_Endothelial21.5
CD14+_Monocytes24.95
CD19+_BCells(neg._sel.)30.25
CD33+_Myeloid30.35
CD34+21.65
CD4+_Tcells17.7
CD56+_NKCells65.35
CD71+_EarlyErythroid20.35
CD8+_Tcells16.75
CardiacMyocytes43.8
Caudatenucleus17.55
Cerebellum15.05
CerebellumPeduncles26.9
CiliaryGanglion28.65
CingulateCortex20.95
Colorectaladenocarcinoma138.15
DorsalRootGanglion20.85
FetalThyroid22.9
Fetalbrain17.3
Fetalliver18.6
Fetallung13.05
GlobusPallidus16.5
Heart30.9
Hypothalamus20.9
Kidney18.35
Leukemia_chronicMyelogenousK-56218.1
Leukemia_promyelocytic-HL-6019.35
Leukemialymphoblastic(MOLT-4)34.95
Liver37.95
Lung21.7
Lymphnode14.15
Lymphoma_burkitts(Daudi)33.8
Lymphoma_burkitts(Raji)33.5
MedullaOblongata16.3
OccipitalLobe19.85
OlfactoryBulb16.8
Ovary17.1
Pancreas38
PancreaticIslet21.75
ParietalLobe23.3
Pituitary24.35
Placenta19.95
Pons19.25
PrefrontalCortex32.5
Prostate20.7
Salivarygland16.45
SkeletalMuscle34.6
Skin21.4
SmoothMuscle31.35
Spinalcord19.5
SubthalamicNucleus19.75
SuperiorCervicalGanglion37.65
TemporalLobe21.15
Testis15.9
TestisGermCell13.9
TestisIntersitial17.2
TestisLeydigCell26.9
TestisSeminiferousTubule16.4
Thalamus20.8
Thymus16.85
Thyroid19.4
Tongue23.75
Tonsil22.65
Trachea15.25
TrigeminalGanglion29.45
Uterus17.45
UterusCorpus21.2
WholeBlood20.5
Wholebrain16.85
colon49.1
pineal_day26.7
pineal_night29.64
retina29.925
small_intestine70
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5243_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.41 ± 0.4
Basal Forebrain8.71 ± 0.29
Basal Part of Pons8.71 ± 0.34
Cerebellar Cortex8.45 ± 0.24
Cerebellar Nuclei8.87 ± 0.29
Claustrum9.33 ± 0.6
Epithalamus8.41 ± 0.4
Frontal Lobe8.75 ± 0.42
Globus Pallidus8.77 ± 0.27
Hypothalamus8.44 ± 0.64
Insula8.8 ± 0.35
Limbic Lobe9.2 ± 0.47
Mesencephalon8.89 ± 0.4
Myelencephalon8.87 ± 0.46
Occipital Lobe9.19 ± 0.49
Parietal Lobe8.84 ± 0.45
Pontine Tegmentum8.9 ± 0.4
Striatum9.39 ± 0.31
Subthalamus8.9 ± 0.19
Temporal Lobe8.86 ± 0.34
Thalamus8.73 ± 0.34
White Matter8.73 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cyb5bCBCerebellum24.63
34.23
Cyb5bCTXCerebral cortex78.04
63.29
Cyb5bHIPHippocampal region49.04
82.52
Cyb5bHPFHippocampal formation56.66
74.43
Cyb5bHYHypothalamus50.02
44.07
Cyb5bLSXLateral septal complex65.9
54.1
Cyb5bMBMidbrain39.54
39.21
Cyb5bMYMedulla49.09
55.59
Cyb5bOLFOlfactory bulb73.29
64.16
Cyb5bPPons41.92
46.85
Cyb5bPALPallidum49.51
50.66
Cyb5bRHPRetrohippocampal region73.17
65.03
Cyb5bsAMYStriatum-like amygdalar nuclei82.75
68.79
Cyb5bSTRStriatum46.97
36.54
Cyb5bSTRdStriatum dorsal region35.39
27
Cyb5bSTRvStriatum ventral region56.19
40.69
Cyb5bTHThalamus52.08
47.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CYB5B_HUMAN_0 0 0 0 GQEVETSVTYYR PRIDE
CYB5B_HUMAN_0 0 0 0 QYYIGDIHPSDLKPESGSK PRIDE
CYB5B_HUMAN_12 12 12 23 GQEVETSVTYYR PRIDE
CYB5B_HUMAN_13 12 13 24 GQEVETSVTYYR PRIDE
CYB5B_HUMAN_31 13 31 43 NSLKELWLVIHGR PRIDE
CYB5B_HUMAN_32 13 32 44 NSLKELWLVIHGR PRIDE
CYB5B_HUMAN_35 9 35 43 ELWLVIHGR PRIDE
CYB5B_HUMAN_36 9 36 44 ELWLVIHGR PRIDE
CYB5B_HUMAN_45 6 45 50 VYDVTR PRIDE
CYB5B_HUMAN_51 34 51 84 FLNEHPGGEEVLLEQAGVDASESFEDVGHSSDAR PRIDE
CYB5B_HUMAN_88 19 88 106 QYYIGDIHPSDLKPESGSK PRIDE
CYB5B_HUMAN_88 28 88 115 QYYIGDIHPSDLKPESGSKDPSKNDTCK PRIDE
CYB5B_HUMAN_89 19 89 107 QYYIGDIHPSDLKPESGSK PRIDE
PAp00000382 19 70 88 AGVDASESFEDVGHSSDAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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