AutismKB 2.0

Annotation Detail for TXNDC5


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Basic Information Top
Gene Symbol:TXNDC5 ( ERP46,EndoPDI,Hcc-2,MGC3178,PDIA15,UNQ364 )
Gene Full Name: thioredoxin domain containing 5 (endoplasmic reticulum)
Band: 6p24.3
Quick LinksEntrez ID:81567; OMIM: NA; Uniprot ID:TXND5_HUMAN; ENSEMBL ID: ENSG00000188428,ENSG00000239264; HGNC ID: 21073
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst8 / 62319128
fetus72 / 564012127
neonate23 / 31097739
infant0 / 236200 
juvenile11 / 55556197
adult386 / 1939121199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma3 / 17475171
breast (mammary gland) tumor20 / 94178212
cervical tumor13 / 34366378
chondrosarcoma35 / 82823422
colorectal tumor56 / 114246490
esophageal tumor3 / 17290173
gastrointestinal tumor29 / 119369242
germ cell tumor54 / 263845204
glioma9 / 10688384
head and neck tumor37 / 136302271
kidney tumor40 / 68959580
leukemia19 / 95842198
liver tumor43 / 96359446
lung tumor35 / 103127339
lymphoma36 / 71755501
non-neoplasia5 / 9725051
normal405 / 3360307120
ovarian tumor32 / 76682417
pancreatic tumor37 / 104616353
primitive neuroectodermal tumor of the CNS27 / 125680214
prostate cancer52 / 102680506
retinoblastoma24 / 46356517
skin tumor88 / 124949704
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor23 / 90257254
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland8 / 33197240
ascites11 / 40015274
bladder3 / 29757100
blood40 / 123478323
bone33 / 71655460
bone marrow16 / 48801327
brain48 / 110098943
cervix16 / 48171332
connective tissue25 / 149255167
ear3 / 16212185
embryonic tissue36 / 215722166
esophagus3 / 20209148
eye42 / 211054199
heart32 / 89626357
intestine88 / 234472375
kidney48 / 211777226
larynx6 / 24145248
liver51 / 207743245
lung87 / 336974258
lymph25 / 44270564
lymph node13 / 91610141
mammary gland28 / 153271182
mouth13 / 67052193
muscle17 / 107715157
nerve1 / 1576863
ovary52 / 102051509
pancreas51 / 214812237
parathyroid4 / 20539194
pharynx8 / 41328193
pituitary gland6 / 16585361
placenta45 / 280825160
prostate57 / 189345301
salivary gland6 / 20155297
skin114 / 210574541
spleen9 / 53952166
stomach22 / 96619227
testis21 / 33044263
thymus0 / 811310 
thyroid16 / 47473337
tonsil5 / 16999294
trachea4 / 5241376
umbilical cord22 / 136801608
uterus45 / 232878193
vascular16 / 51780308
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221253_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1030.7
Adipocyte809.6
AdrenalCortex235.8
Adrenalgland315.3
Amygdala81.5
Appendix87.6
AtrioventricularNode48.85
BDCA4+_DentriticCells4853
Bonemarrow720.5
BronchialEpithelialCells1157.65
CD105+_Endothelial999.95
CD14+_Monocytes134.05
CD19+_BCells(neg._sel.)1623.4
CD33+_Myeloid328.75
CD34+1318.8
CD4+_Tcells64.1
CD56+_NKCells1008.7
CD71+_EarlyErythroid290.4
CD8+_Tcells63.35
CardiacMyocytes2836.5
Caudatenucleus60.75
Cerebellum39.7
CerebellumPeduncles31.4
CiliaryGanglion31.85
CingulateCortex58.9
Colorectaladenocarcinoma351.35
DorsalRootGanglion53.05
FetalThyroid294.35
Fetalbrain77.75
Fetalliver390.85
Fetallung498.4
GlobusPallidus14.25
Heart83.05
Hypothalamus105.4
Kidney161.5
Leukemia_chronicMyelogenousK-562690.65
Leukemia_promyelocytic-HL-60277.85
Leukemialymphoblastic(MOLT-4)113.1
Liver409.8
Lung728.1
Lymphnode1801.5
Lymphoma_burkitts(Daudi)838.7
Lymphoma_burkitts(Raji)121.9
MedullaOblongata58
OccipitalLobe56.5
OlfactoryBulb248.15
Ovary82.65
Pancreas561.25
PancreaticIslet723.6
ParietalLobe58.5
Pituitary372.8
Placenta840.95
Pons28.45
PrefrontalCortex96.2
Prostate434
Salivarygland757.1
SkeletalMuscle86.3
Skin41.7
SmoothMuscle3315.95
Spinalcord144
SubthalamicNucleus21.2
SuperiorCervicalGanglion41.65
TemporalLobe29.3
Testis167
TestisGermCell196.35
TestisIntersitial36.4
TestisLeydigCell75.5
TestisSeminiferousTubule54.4
Thalamus78.2
Thymus235.35
Thyroid536.6
Tongue84.5
Tonsil822.45
Trachea1075.75
TrigeminalGanglion35.1
Uterus390.55
UterusCorpus258.05
WholeBlood128.05
Wholebrain87.55
colon753.9
pineal_day102.72
pineal_night96
retina210.125
small_intestine1747.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P168229
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.97 ± 0.32
Basal Forebrain7.05 ± 0.23
Basal Part of Pons6.69 ± 0.18
Cerebellar Cortex6.77 ± 0.23
Cerebellar Nuclei7.22 ± 0.17
Claustrum6.87 ± 0.33
Epithalamus7.14 ± 0.28
Frontal Lobe7.02 ± 0.26
Globus Pallidus7.28 ± 0.2
Hypothalamus7.45 ± 0.23
Insula6.96 ± 0.2
Limbic Lobe6.89 ± 0.37
Mesencephalon7.11 ± 0.28
Myelencephalon7.04 ± 0.24
Occipital Lobe7.2 ± 0.34
Parietal Lobe6.96 ± 0.34
Pontine Tegmentum7.13 ± 0.22
Striatum7.11 ± 0.23
Subthalamus7.06 ± 0.38
Temporal Lobe6.97 ± 0.28
Thalamus7.07 ± 0.24
White Matter7.87 ± 0.08
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Txndc5CBCerebellum10.87
14.71
Txndc5CTXCerebral cortex47.04
37.84
Txndc5HIPHippocampal region34.81
41.57
Txndc5HPFHippocampal formation38.82
41.77
Txndc5HYHypothalamus72.21
72.5
Txndc5LSXLateral septal complex87.57
80.3
Txndc5MBMidbrain32.29
36.57
Txndc5MYMedulla33.64
50.54
Txndc5OLFOlfactory bulb64.52
59.13
Txndc5PPons38.7
52.7
Txndc5PALPallidum67.16
71
Txndc5RHPRetrohippocampal region49.42
45.32
Txndc5sAMYStriatum-like amygdalar nuclei98.14
86.09
Txndc5STRStriatum68.44
55.86
Txndc5STRdStriatum dorsal region54.36
42.25
Txndc5STRvStriatum ventral region92.54
73.54
Txndc5THThalamus54.01
51.09
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003673 10 376 385 IAEVDCTAER Peptide Atlas
TXND5_HUMAN_118 16 118 133 VDCTAHSDVCSAQGVR PRIDE
TXND5_HUMAN_119 16 119 134 VDCTAHSDVCSAQGVR PRIDE
TXND5_HUMAN_221 20 221 240 ALAPTWEQLALGLEHSETVK PRIDE
TXND5_HUMAN_222 20 222 241 ALAPTWEQLALGLEHSETVK PRIDE
TXND5_HUMAN_241 19 241 259 IGKVDCTQHYELCSGNQVR PRIDE
TXND5_HUMAN_260 9 260 268 GYPTLLWFR PRIDE
TXND5_HUMAN_281 15 281 295 DLESLREYVESQLQR PRIDE
TXND5_HUMAN_287 9 287 295 EYVESQLQR PRIDE
TXND5_HUMAN_39 23 39 61 QEAAAAAADGPPAADGEDGQDPH PRIDE
TXND5_HUMAN_394 9 394 402 GYPTLLLFR PRIDE
TXND5_HUMAN_395 9 395 403 GYPTLLLFR PRIDE
TXND5_HUMAN_407 15 407 421 VSEHSGGRDLDSLHR PRIDE
TXND5_HUMAN_422 10 422 431 FVLSQAKDEL PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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