AutismKB 2.0

Annotation Detail for PLA2G12A


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Basic Information Top
Gene Symbol:PLA2G12A ( GXII,PLA2G12,ROSSY )
Gene Full Name: phospholipase A2, group XIIA
Band: 4q25
Quick LinksEntrez ID:81579; OMIM: 611652; Uniprot ID:PG12A_HUMAN; ENSEMBL ID: ENSG00000123739; HGNC ID: 18554
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus50 / 56401288
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma5 / 10688346
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal170 / 336030750
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood3 / 12347824
bone5 / 7165569
bone marrow2 / 4880140
brain44 / 110098939
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye9 / 21105442
heart4 / 8962644
intestine7 / 23447229
kidney14 / 21177766
larynx0 / 241450 
liver2 / 2077439
lung21 / 33697462
lymph2 / 4427045
lymph node2 / 9161021
mammary gland4 / 15327126
mouth1 / 6705214
muscle6 / 10771555
nerve1 / 1576863
ovary3 / 10205129
pancreas14 / 21481265
parathyroid5 / 20539243
pharynx4 / 4132896
pituitary gland2 / 16585120
placenta13 / 28082546
prostate9 / 18934547
salivary gland3 / 20155148
skin3 / 21057414
spleen1 / 5395218
stomach0 / 966190 
testis8 / 33044224
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus8 / 23287834
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221027_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.1
Adipocyte7.3
AdrenalCortex10.55
Adrenalgland7.1
Amygdala7.7
Appendix9.8
AtrioventricularNode8.85
BDCA4+_DentriticCells7.15
Bonemarrow8.65
BronchialEpithelialCells7.3
CD105+_Endothelial49.5
CD14+_Monocytes8.2
CD19+_BCells(neg._sel.)8.7
CD33+_Myeloid8.95
CD34+9.55
CD4+_Tcells7.4
CD56+_NKCells8.3
CD71+_EarlyErythroid8.55
CD8+_Tcells6.45
CardiacMyocytes13.85
Caudatenucleus6.85
Cerebellum6.25
CerebellumPeduncles9.65
CiliaryGanglion7.3
CingulateCortex8.25
Colorectaladenocarcinoma7.45
DorsalRootGanglion7.55
FetalThyroid9.45
Fetalbrain7.05
Fetalliver7.75
Fetallung5.7
GlobusPallidus6.4
Heart12.9
Hypothalamus7.65
Kidney7.6
Leukemia_chronicMyelogenousK-56211.05
Leukemia_promyelocytic-HL-609.2
Leukemialymphoblastic(MOLT-4)5.8
Liver12.35
Lung8.1
Lymphnode5.9
Lymphoma_burkitts(Daudi)11.45
Lymphoma_burkitts(Raji)13.1
MedullaOblongata7.05
OccipitalLobe6.75
OlfactoryBulb5.85
Ovary5.95
Pancreas6.7
PancreaticIslet11.35
ParietalLobe8.8
Pituitary10.4
Placenta8
Pons8.35
PrefrontalCortex8.6
Prostate12.2
Salivarygland6.65
SkeletalMuscle12.25
Skin8.05
SmoothMuscle8.6
Spinalcord8.3
SubthalamicNucleus7.75
SuperiorCervicalGanglion13.95
TemporalLobe7.35
Testis6.45
TestisGermCell5.95
TestisIntersitial7.4
TestisLeydigCell8.5
TestisSeminiferousTubule6.55
Thalamus8.2
Thymus5.55
Thyroid9.6
Tongue11.6
Tonsil7.65
Trachea6.35
TrigeminalGanglion18.3
Uterus5.75
UterusCorpus7.9
WholeBlood8.35
Wholebrain5.85
colon17.05
pineal_day9.34
pineal_night12.12
retina9.525
small_intestine10.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P706752
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.51 ± 0.27
Basal Forebrain7.8 ± 0.19
Basal Part of Pons7.52 ± 0.26
Cerebellar Cortex7.72 ± 0.17
Cerebellar Nuclei8.16 ± 0.2
Claustrum7.61 ± 0.28
Epithalamus7.85 ± 0.28
Frontal Lobe7.67 ± 0.26
Globus Pallidus8.37 ± 0.23
Hypothalamus7.65 ± 0.27
Insula7.71 ± 0.22
Limbic Lobe7.53 ± 0.31
Mesencephalon7.8 ± 0.34
Myelencephalon7.66 ± 0.28
Occipital Lobe7.66 ± 0.3
Parietal Lobe7.59 ± 0.29
Pontine Tegmentum7.69 ± 0.28
Striatum7.85 ± 0.27
Subthalamus8 ± 0.18
Temporal Lobe7.55 ± 0.23
Thalamus7.58 ± 0.33
White Matter8.38 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pla2g12aCBCerebellum5.5
4.92
Pla2g12aCTXCerebral cortex1.51
0.94
Pla2g12aHIPHippocampal region14.04
7.11
Pla2g12aHPFHippocampal formation9.4
4.93
Pla2g12aHYHypothalamus0.7
0.45
Pla2g12aLSXLateral septal complex0.76
0.45
Pla2g12aMBMidbrain2.37
2.19
Pla2g12aMYMedulla3.71
2.71
Pla2g12aOLFOlfactory bulb4.42
2.94
Pla2g12aPPons2.43
1.85
Pla2g12aPALPallidum1.15
0.67
Pla2g12aRHPRetrohippocampal region4.22
2.66
Pla2g12asAMYStriatum-like amygdalar nuclei0.62
0.45
Pla2g12aSTRStriatum0.87
0.46
Pla2g12aSTRdStriatum dorsal region0.43
0.27
Pla2g12aSTRvStriatum ventral region2.27
0.92
Pla2g12aTHThalamus1.8
1.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00075305 27 40 66 NGVHKIDTYLNAALDLLGGEDGLCQYK Peptide Atlas
PG12A_HUMAN_24 9 24 32 EQAQTTDWR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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