AutismKB 2.0

Annotation Detail for TRIM8


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Basic Information Top
Gene Symbol:TRIM8 ( GERP,RNF27 )
Gene Full Name: tripartite motif-containing 8
Band: 10q24.32
Quick LinksEntrez ID:81603; OMIM: 606125; Uniprot ID:TRIM8_HUMAN; ENSEMBL ID: ENSG00000171206; HGNC ID: 15579
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus24 / 56401242
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult97 / 193912150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma19 / 106883177
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor5 / 9635951
lung tumor14 / 103127135
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal158 / 336030747
ovarian tumor8 / 76682104
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone2 / 7165527
bone marrow0 / 488010 
brain27 / 110098924
cervix1 / 4817120
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye18 / 21105485
heart4 / 8962644
intestine13 / 23447255
kidney29 / 211777136
larynx2 / 2414582
liver5 / 20774324
lung43 / 336974127
lymph0 / 442700 
lymph node11 / 91610120
mammary gland11 / 15327171
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary9 / 10205188
pancreas16 / 21481274
parathyroid6 / 20539292
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta5 / 28082517
prostate10 / 18934552
salivary gland1 / 2015549
skin9 / 21057442
spleen2 / 5395237
stomach5 / 9661951
testis0 / 3304420 
thymus9 / 81131110
thyroid1 / 4747321
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221012_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts58.25
Adipocyte190.6
AdrenalCortex60.95
Adrenalgland75.35
Amygdala173.4
Appendix47.2
AtrioventricularNode50.85
BDCA4+_DentriticCells261.8
Bonemarrow55.55
BronchialEpithelialCells76.5
CD105+_Endothelial90.75
CD14+_Monocytes255.65
CD19+_BCells(neg._sel.)72.55
CD33+_Myeloid448.2
CD34+156.1
CD4+_Tcells102.5
CD56+_NKCells423.3
CD71+_EarlyErythroid7.05
CD8+_Tcells88.05
CardiacMyocytes118.9
Caudatenucleus75.55
Cerebellum87.4
CerebellumPeduncles84.75
CiliaryGanglion58.05
CingulateCortex111.35
Colorectaladenocarcinoma64.3
DorsalRootGanglion40.3
FetalThyroid153.15
Fetalbrain69.35
Fetalliver27.45
Fetallung92.85
GlobusPallidus55
Heart139.6
Hypothalamus220.9
Kidney177.35
Leukemia_chronicMyelogenousK-56218.85
Leukemia_promyelocytic-HL-6030.55
Leukemialymphoblastic(MOLT-4)20.2
Liver95.4
Lung290.2
Lymphnode56.3
Lymphoma_burkitts(Daudi)53.8
Lymphoma_burkitts(Raji)47.5
MedullaOblongata63.15
OccipitalLobe99.4
OlfactoryBulb106.65
Ovary45.75
Pancreas69.8
PancreaticIslet143
ParietalLobe81.9
Pituitary81.3
Placenta71.65
Pons62.8
PrefrontalCortex147.45
Prostate199.55
Salivarygland66.9
SkeletalMuscle57.05
Skin59.15
SmoothMuscle301.55
Spinalcord105.15
SubthalamicNucleus60.5
SuperiorCervicalGanglion79.25
TemporalLobe65.85
Testis79.55
TestisGermCell59.95
TestisIntersitial16.25
TestisLeydigCell34.35
TestisSeminiferousTubule29.6
Thalamus113
Thymus158.95
Thyroid249.95
Tongue71.65
Tonsil83.5
Trachea71.35
TrigeminalGanglion67.9
Uterus96
UterusCorpus62.6
WholeBlood348
Wholebrain164.15
colon135.05
pineal_day162.76
pineal_night169.92
retina388.725
small_intestine138.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1757_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.66 ± 0.48
Basal Forebrain5.57 ± 0.35
Basal Part of Pons5.05 ± 0.36
Cerebellar Cortex5.15 ± 0.35
Cerebellar Nuclei5.42 ± 0.49
Claustrum5.66 ± 0.77
Epithalamus5.31 ± 0.55
Frontal Lobe5.12 ± 0.44
Globus Pallidus5.98 ± 0.4
Hypothalamus4.63 ± 0.39
Insula5.23 ± 0.45
Limbic Lobe5.42 ± 0.58
Mesencephalon5.41 ± 0.51
Myelencephalon5.47 ± 0.52
Occipital Lobe5.86 ± 0.68
Parietal Lobe5.34 ± 0.46
Pontine Tegmentum5.29 ± 0.66
Striatum5.99 ± 0.57
Subthalamus4.4 ± 0.25
Temporal Lobe5.13 ± 0.45
Thalamus5.59 ± 0.47
White Matter5.49 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Trim8CBCerebellum1.22
1.48
Trim8CTXCerebral cortex1.03
0.79
Trim8HIPHippocampal region1.02
0.71
Trim8HPFHippocampal formation0.84
0.62
Trim8HYHypothalamus0.03
0.03
Trim8LSXLateral septal complex0.18
0.1
Trim8MBMidbrain0.42
0.7
Trim8MYMedulla0.8
1.07
Trim8OLFOlfactory bulb1.54
1.69
Trim8PPons1.3
1.46
Trim8PALPallidum0.09
0.11
Trim8RHPRetrohippocampal region0.46
0.47
Trim8sAMYStriatum-like amygdalar nuclei0.03
0
Trim8STRStriatum0.29
0.33
Trim8STRdStriatum dorsal region0.15
0.15
Trim8STRvStriatum ventral region0.91
1.01
Trim8THThalamus0.25
0.21
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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