AutismKB 2.0

Annotation Detail for MAP1LC3B


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Basic Information Top
Gene Symbol:MAP1LC3B ( ATG8F,LC3B,MAP1A/1BLC3 )
Gene Full Name: microtubule-associated protein 1 light chain 3 beta
Band: 16q24.2
Quick LinksEntrez ID:81631; OMIM: 609604; Uniprot ID:MLP3B_HUMAN; ENSEMBL ID: ENSG00000140941; HGNC ID: 13352
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst3 / 6231948
fetus115 / 564012203
neonate7 / 31097225
infant0 / 236200 
juvenile7 / 55556125
adult344 / 1939121177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor12 / 94178127
cervical tumor6 / 34366174
chondrosarcoma10 / 82823120
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor13 / 119369108
germ cell tumor102 / 263845386
glioma30 / 106883280
head and neck tumor15 / 136302110
kidney tumor19 / 68959275
leukemia5 / 9584252
liver tumor8 / 9635983
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia14 / 97250143
normal769 / 3360307228
ovarian tumor5 / 7668265
pancreatic tumor26 / 104616248
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer9 / 10268087
retinoblastoma7 / 46356151
skin tumor7 / 12494956
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland5 / 33197150
ascites8 / 40015199
bladder6 / 29757201
blood14 / 123478113
bone11 / 71655153
bone marrow10 / 48801204
brain324 / 1100989294
cervix6 / 48171124
connective tissue21 / 149255140
ear1 / 1621261
embryonic tissue23 / 215722106
esophagus0 / 202090 
eye36 / 211054170
heart39 / 89626435
intestine33 / 234472140
kidney47 / 211777221
larynx1 / 2414541
liver12 / 20774357
lung45 / 336974133
lymph1 / 4427022
lymph node5 / 9161054
mammary gland16 / 153271104
mouth8 / 67052119
muscle3 / 10771527
nerve2 / 15768126
ovary6 / 10205158
pancreas36 / 214812167
parathyroid11 / 20539535
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta82 / 280825291
prostate23 / 189345121
salivary gland1 / 2015549
skin47 / 210574223
spleen13 / 53952240
stomach10 / 96619103
testis76 / 330442229
thymus28 / 81131345
thyroid9 / 47473189
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord1 / 1368073
uterus42 / 232878180
vascular29 / 51780560
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208786_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts252.8
Adipocyte387.75
AdrenalCortex276.65
Adrenalgland268.1
Amygdala986.6
Appendix191.5
AtrioventricularNode72.4
BDCA4+_DentriticCells498.05
Bonemarrow272.6
BronchialEpithelialCells582.45
CD105+_Endothelial161.1
CD14+_Monocytes366.6
CD19+_BCells(neg._sel.)524.85
CD33+_Myeloid476.95
CD34+251.75
CD4+_Tcells228.85
CD56+_NKCells543.8
CD71+_EarlyErythroid356.4
CD8+_Tcells229.9
CardiacMyocytes570.8
Caudatenucleus414
Cerebellum926.2
CerebellumPeduncles1038.3
CiliaryGanglion168.7
CingulateCortex402
Colorectaladenocarcinoma245.05
DorsalRootGanglion262.7
FetalThyroid239.85
Fetalbrain448.7
Fetalliver105.35
Fetallung239.5
GlobusPallidus349
Heart177.65
Hypothalamus784.3
Kidney142.15
Leukemia_chronicMyelogenousK-562550.65
Leukemia_promyelocytic-HL-6098.7
Leukemialymphoblastic(MOLT-4)151.9
Liver109.2
Lung336.05
Lymphnode254.8
Lymphoma_burkitts(Daudi)319.95
Lymphoma_burkitts(Raji)160.25
MedullaOblongata626.05
OccipitalLobe863.6
OlfactoryBulb283.3
Ovary132.95
Pancreas122.2
PancreaticIslet364.15
ParietalLobe701.3
Pituitary336.3
Placenta845.85
Pons354.9
PrefrontalCortex1004.75
Prostate264
Salivarygland235.8
SkeletalMuscle226.95
Skin86.25
SmoothMuscle921
Spinalcord813.05
SubthalamicNucleus496.45
SuperiorCervicalGanglion122.2
TemporalLobe468
Testis401.2
TestisGermCell305.35
TestisIntersitial362.7
TestisLeydigCell321.85
TestisSeminiferousTubule252.85
Thalamus734
Thymus241.95
Thyroid496.65
Tongue187.6
Tonsil195.05
Trachea200.45
TrigeminalGanglion103
Uterus279.9
UterusCorpus310.25
WholeBlood656.95
Wholebrain936.25
colon215.1
pineal_day951.46
pineal_night1027.24
retina740.1
small_intestine145.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P77630
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.29 ± 0.34
Basal Forebrain9.58 ± 0.46
Basal Part of Pons9.65 ± 0.3
Cerebellar Cortex9.44 ± 0.34
Cerebellar Nuclei9.8 ± 0.3
Claustrum9.64 ± 0.27
Epithalamus9.04 ± 0.38
Frontal Lobe9.4 ± 0.38
Globus Pallidus9.88 ± 0.21
Hypothalamus9.55 ± 0.36
Insula9.2 ± 0.33
Limbic Lobe9.5 ± 0.42
Mesencephalon9.66 ± 0.4
Myelencephalon9.46 ± 0.34
Occipital Lobe9.79 ± 0.24
Parietal Lobe9.63 ± 0.32
Pontine Tegmentum9.5 ± 0.36
Striatum9.11 ± 0.34
Subthalamus9.76 ± 0.19
Temporal Lobe9.39 ± 0.29
Thalamus9.58 ± 0.27
White Matter9.78 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map1lc3bCBCerebellum91.8
100
Map1lc3bCTXCerebral cortex100
100
Map1lc3bHIPHippocampal region100
100
Map1lc3bHPFHippocampal formation100
100
Map1lc3bHYHypothalamus59.74
68.07
Map1lc3bLSXLateral septal complex57.08
53.92
Map1lc3bMBMidbrain100
100
Map1lc3bMYMedulla100
100
Map1lc3bOLFOlfactory bulb83.91
100
Map1lc3bPPons95.08
100
Map1lc3bPALPallidum74.82
100
Map1lc3bRHPRetrohippocampal region100
100
Map1lc3bsAMYStriatum-like amygdalar nuclei69.09
65.93
Map1lc3bSTRStriatum86.1
84.53
Map1lc3bSTRdStriatum dorsal region94.82
94.71
Map1lc3bSTRvStriatum ventral region79.79
74.37
Map1lc3bTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MLP3B_HUMAN_1 9 1 9 PSEKTFKQR PRIDE
MLP3B_HUMAN_2 9 2 10 PSEKTFKQR PRIDE
MLP3B_HUMAN_51 14 51 64 FLVPDHVNMSELIK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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